6ZQS

Crystal structure of double-phosphorylated p38alpha with ATF2(83-102)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Protein kinase-like (PK-like)	8033039	3000066	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Pkinase_Tyr	e6zqsA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Mitogen-activated protein kinase 14	protein phosphatase binding phosphatase binding protein binding binding enzyme binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding protein phosphatase binding phosphatase binding protein binding binding enzyme binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity MAP kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding NFAT protein binding protein serine kinase activity kinase binding mitogen-activated protein kinase p38 binding protein kinase binding mitogen-activated protein kinase binding	cellular response to stimulus stress-induced premature senescence cellular response to stress response to stimulus response to stress cellular senescence metabolic process cellular process regulation of biological process regulation of cellular process signaling biological regulation p38MAPK cascade intracellular signal transduction cellular response to stimulus stress-induced premature senescence cellular response to stress response to stimulus response to stress cellular senescence metabolic process cellular process regulation of biological process regulation of cellular process signaling biological regulation p38MAPK cascade intracellular signal transduction cell communication intracellular signaling cassette MAPK cascade signal transduction developmental process regulation of developmental process cellular developmental process positive regulation of biological process regulation of cell differentiation positive regulation of myoblast differentiation muscle structure development positive regulation of developmental process positive regulation of cell differentiation cell differentiation anatomical structure development regulation of myoblast differentiation myoblast differentiation positive regulation of cellular process placenta development animal organ development regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process multicellular organismal process regulation of growth positive regulation of cell population proliferation regulation of cardiac muscle tissue growth developmental growth cardiac muscle cell proliferation organ growth striated muscle tissue development multicellular organism development positive regulation of cardiac muscle cell proliferation regulation of organ growth regulation of heart growth regulation of cardiac muscle cell proliferation muscle cell proliferation regulation of multicellular organismal process cardiac muscle tissue growth muscle tissue development positive regulation of developmental growth system development striated muscle cell proliferation positive regulation of heart growth heart development heart growth regulation of multicellular organismal development cell population proliferation regulation of developmental growth cardiac muscle tissue development positive regulation of organ growth growth tissue development circulatory system development positive regulation of growth regulation of cell population proliferation positive regulation of cardiac muscle tissue growth positive regulation of multicellular organismal process skeletal system development bone development positive regulation of molecular function regulation of molecular function positive regulation of cyclase activity regulation of catalytic activity positive regulation of catalytic activity regulation of cyclase activity apoptotic process cell death programmed cell death negative regulation of signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication negative regulation of Wnt signaling pathway negative regulation of cellular process Wnt signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway regulation of response to stimulus regulation of cell communication response to ionizing radiation cellular response to ionizing radiation response to radiation response to abiotic stimulus cellular response to radiation cellular response to abiotic stimulus cellular response to environmental stimulus cell aggregation connective tissue development cartilage condensation anatomical structure morphogenesis skeletal system morphogenesis animal organ morphogenesis cartilage development protein localization regulation of localization cellular localization establishment of protein localization nitrogen compound transport regulation of protein localization nucleocytoplasmic transport transport positive regulation of nucleocytoplasmic transport nuclear transport positive regulation of establishment of protein localization regulation of protein localization to nucleus positive regulation of protein transport localization import into nucleus regulation of protein import into nucleus cellular macromolecule localization establishment of localization in cell protein import into nucleus positive regulation of intracellular transport regulation of intracellular transport regulation of transport positive regulation of protein localization to nucleus regulation of establishment of protein localization positive regulation of protein import into nucleus intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus regulation of protein transport establishment of localization positive regulation of transport establishment of protein localization to organelle regulation of cellular localization protein transport macromolecule localization protein localization to organelle positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process small molecule metabolic process primary metabolic process glucose metabolic process response to light stimulus response to UV response to UV-B cellular response to UV-B cellular response to light stimulus cellular response to UV chemotaxis taxis response to chemical response to external stimulus locomotion regulation of body fluid levels wound healing cell activation hemostasis blood coagulation coagulation regulation of biological quality response to wounding platelet activation hippo signaling negative regulation of intracellular signal transduction regulation of intracellular signal transduction negative regulation of hippo signaling regulation of hippo signaling regulation of striated muscle cell differentiation muscle cell differentiation myotube differentiation positive regulation of myotube differentiation positive regulation of striated muscle cell differentiation regulation of myotube differentiation positive regulation of muscle cell differentiation regulation of muscle cell differentiation striated muscle cell differentiation cell morphogenesis homeostatic process cell development regulation of cell development regulation of immune system process myeloid cell homeostasis erythrocyte homeostasis hemopoiesis regulation of myeloid cell differentiation erythrocyte differentiation regulation of erythrocyte differentiation positive regulation of erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process positive regulation of myeloid cell differentiation regulation of hemopoiesis homeostasis of number of cells biological process involved in interspecies interaction between organisms cellular response to lipoteichoic acid response to other organism response to oxygen-containing compound response to lipoteichoic acid cellular response to molecule of bacterial origin cellular response to oxygen-containing compound response to biotic stimulus cellular response to biotic stimulus cellular response to chemical stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin cell surface receptor protein serine/threonine kinase signaling pathway enzyme-linked receptor protein signaling pathway regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response inflammatory response to antigenic stimulus regulation of response to stress negative regulation of inflammatory response to antigenic stimulus defense response immune response negative regulation of immune response regulation of inflammatory response to antigenic stimulus regulation of inflammatory response negative regulation of immune system process negative regulation of response to external stimulus negative regulation of defense response regulation of immune response inflammatory response protein phosphorylation phosphorylation peptidyl-serine modification peptidyl-serine phosphorylation macromolecule modification peptidyl-amino acid modification phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process positive regulation of cellular component organization regulation of cellular component organization regulation of syncytium formation by plasma membrane fusion cell-cell fusion cellular component organization cellular component organization or biogenesis syncytium formation positive regulation of myoblast fusion myoblast fusion regulation of myoblast fusion positive regulation of syncytium formation by plasma membrane fusion syncytium formation by plasma membrane fusion anatomical structure formation involved in morphogenesis regulation of cell adhesion regulation of synaptic membrane adhesion regulation of synapse organization cell adhesion cell junction organization cell-cell adhesion regulation of synapse structure or activity regulation of cell-cell adhesion synapse organization synaptic membrane adhesion cell-cell adhesion via plasma-membrane adhesion molecules chondrocyte differentiation regulation of primary metabolic process nucleobase-containing compound metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process RNA catabolic process mRNA stabilization mRNA catabolic process negative regulation of metabolic process nucleobase-containing compound catabolic process negative regulation of gene expression negative regulation of macromolecule biosynthetic process nucleic acid catabolic process negative regulation of RNA metabolic process catabolic process RNA metabolic process macromolecule catabolic process negative regulation of mRNA metabolic process 3'-UTR-mediated mRNA stabilization regulation of mRNA catabolic process negative regulation of macromolecule metabolic process negative regulation of catabolic process negative regulation of mRNA catabolic process negative regulation of RNA catabolic process regulation of catabolic process mRNA metabolic process nucleic acid metabolic process regulation of mRNA stability RNA stabilization negative regulation of biosynthetic process regulation of RNA stability regulation of mRNA metabolic process positive regulation of DNA-templated transcription RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription transcription by RNA polymerase II regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription cellular response to endogenous stimulus cellular response to growth factor stimulus response to endogenous stimulus cellular response to vascular endothelial growth factor stimulus response to growth factor DNA damage checkpoint signaling regulation of cell cycle phase transition negative regulation of cell cycle cell cycle phase transition negative regulation of cell cycle phase transition cell cycle regulation of cell cycle cell cycle process regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling DNA damage response signal transduction in response to DNA damage ossification osteoblast differentiation blood vessel morphogenesis tube development angiogenesis vasculature development tube morphogenesis blood vessel development stress-activated MAPK cascade stress-activated protein kinase signaling cascade response to lipid cellular response to lipopolysaccharide lipopolysaccharide-mediated signaling pathway response to lipopolysaccharide cellular response to lipid regulation of ossification skeletal muscle organ development skeletal muscle tissue development muscle organ development regulation of interleukin-12 production cytokine production regulation of cytokine production interleukin-12 production positive regulation of interleukin-12 production positive regulation of cytokine production reactive oxygen species metabolic process positive regulation of reactive oxygen species metabolic process regulation of reactive oxygen species metabolic process response to peptide cellular response to tumor necrosis factor response to cytokine cellular response to cytokine stimulus response to tumor necrosis factor fat cell differentiation positive regulation of brown fat cell differentiation positive regulation of fat cell differentiation regulation of brown fat cell differentiation brown fat cell differentiation regulation of fat cell differentiation response to hormone response to peptide hormone response to insulin response to nitrogen compound regulation of cytokine production involved in inflammatory response production of molecular mediator involved in inflammatory response cytokine production involved in inflammatory response fatty acid metabolic process oxoacid metabolic process carboxylic acid metabolic process lipid modification organic acid metabolic process fatty acid oxidation lipid oxidation monocarboxylic acid metabolic process lipid metabolic process response to muramyl dipeptide myeloid leukocyte differentiation osteoclast differentiation leukocyte differentiation stem cell differentiation D-glucose import hexose transmembrane transport carbohydrate transport transmembrane transport D-glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport cell surface receptor protein tyrosine kinase signaling pathway vascular endothelial growth factor receptor signaling pathway positive regulation of D-glucose transmembrane transport positive regulation of transmembrane transport regulation of D-glucose import positive regulation of D-glucose import regulation of transmembrane transport regulation of D-glucose transmembrane transport cellular response to virus response to virus response to mechanical stimulus response to muscle stretch response to nutrient levels response to dietary excess energy homeostasis	intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen cytoplasm cytosol synapse cell junction glutamatergic synapse mitochondrion intracellular vesicle ficolin-1-rich granule endomembrane system cytoplasmic vesicle ficolin-1-rich granule lumen secretory granule secretory vesicle vesicle extracellular region vesicle lumen cytoplasmic vesicle lumen secretory granule lumen
B	Cyclic AMP-dependent transcription factor ATF-2	DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding cAMP response element binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding catalytic activity, acting on a protein DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding cAMP response element binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding catalytic activity, acting on a protein N-acetyltransferase activity acyltransferase activity transferase activity peptide N-acetyltransferase activity histone acetyltransferase activity acetyltransferase activity peptide-lysine-N-acetyltransferase activity histone H2B acetyltransferase activity histone modifying activity acyltransferase activity, transferring groups other than amino-acyl groups catalytic activity N-acyltransferase activity chromatin binding promoter-specific chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity cation binding ion binding metal ion binding small molecule binding identical protein binding protein binding transcription factor binding cAMP response element binding protein binding DNA-binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein heterodimerization activity protein dimerization activity protein homodimerization activity kinase binding enzyme binding protein kinase binding LRR domain binding protein domain specific binding leucine zipper domain binding histone H4 acetyltransferase activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of biological process regulation of cellular process signaling biological regulation p38MAPK cascade intracellular signal transduction cell communication intracellular signaling cassette cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of biological process regulation of cellular process signaling biological regulation p38MAPK cascade intracellular signal transduction cell communication intracellular signaling cassette MAPK cascade signal transduction positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic cellular component organization RNA biosynthetic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II positive regulation of biosynthetic process chromatin organization chromatin remodeling positive regulation of macromolecule metabolic process cellular component organization or biogenesis positive regulation of cellular process transcription initiation at RNA polymerase II promoter regulation of biosynthetic process epigenetic regulation of gene expression primary metabolic process regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation regulation of gene expression biosynthetic process positive regulation of gene expression transcription initiation-coupled chromatin remodeling regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process developmental process anatomical structure development brainstem development multicellular organismal process connective tissue development cellular developmental process developmental growth endochondral bone morphogenesis organ growth multicellular organism development skeletal system development chondrocyte differentiation involved in endochondral bone morphogenesis cell differentiation growth plate cartilage development endochondral bone growth animal organ morphogenesis bone development system development animal organ development growth tissue development anatomical structure morphogenesis growth plate cartilage chondrocyte differentiation bone growth chondrocyte differentiation skeletal system morphogenesis cartilage development involved in endochondral bone morphogenesis bone morphogenesis cartilage development positive regulation of DNA-binding transcription factor activity regulation of primary metabolic process positive regulation of molecular function regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of molecular function regulation of DNA-binding transcription factor activity regulation of DNA-templated transcription protein phosphorylation phosphorylation macromolecule modification peptidyl-amino acid modification phosphate-containing compound metabolic process peptidyl-threonine modification protein metabolic process protein modification process phosphorus metabolic process peptidyl-threonine phosphorylation protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport regulation of transforming growth factor beta production regulation of transforming growth factor beta2 production positive regulation of transforming growth factor beta2 production cytokine production regulation of cytokine production regulation of multicellular organismal process transforming growth factor beta production transforming growth factor beta2 production positive regulation of multicellular organismal process positive regulation of transforming growth factor beta production positive regulation of cytokine production response to oxidative stress cellular response to chemical stimulus response to chemical cellular response to oxidative stress cellular response to chemical stress growth plate cartilage chondrocyte proliferation cell population proliferation embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development JNK cascade mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process DNA damage checkpoint signaling regulation of cell cycle phase transition negative regulation of biological process negative regulation of cell cycle cell cycle phase transition mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling mitotic DNA damage checkpoint signaling negative regulation of cellular process negative regulation of cell cycle phase transition cell cycle mitotic intra-S DNA damage checkpoint signaling regulation of cell cycle cell cycle process regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling mitotic cell cycle process signal transduction in response to DNA damage negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process fat cell differentiation white fat cell differentiation hepaticobiliary system development gland development liver development adipose tissue development cellular response to BMP stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus cell surface receptor signaling pathway response to endogenous stimulus cellular response to endogenous stimulus response to BMP transforming growth factor beta receptor superfamily signaling pathway response to growth factor BMP signaling pathway enzyme-linked receptor protein signaling pathway apoptotic process involved in development apoptotic process cell death programmed cell death neuron apoptotic process motor neuron apoptotic process hemopoiesis cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation alpha-beta T cell differentiation T cell activation immune system process alpha-beta T cell activation NK T cell differentiation T cell differentiation leukocyte differentiation response to nutrient levels cellular response to leucine starvation cellular response to amino acid starvation cellular response to starvation cellular response to nutrient levels response to amino acid starvation response to starvation cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels intrinsic apoptotic signaling pathway response to decreased oxygen levels apoptotic signaling pathway intrinsic apoptotic signaling pathway in response to hypoxia response to hypoxia response to oxygen levels response to abiotic stimulus detection of stimulus detection of cell density detection of biotic stimulus response to biotic stimulus pons development head development brain development nervous system development central nervous system development metencephalon development facial nucleus development hindbrain development neural nucleus development positive regulation of myoblast proliferation myoblast proliferation positive regulation of cell population proliferation regulation of myoblast proliferation regulation of cardiac muscle myoblast proliferation positive regulation of cardiac muscle myoblast proliferation regulation of cell population proliferation cardiac muscle myoblast proliferation abducens nucleus development hepatocyte apoptotic process epithelial cell apoptotic process hypoglossal nucleus development medulla oblongata development positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of phosphate metabolic process positive regulation of protein modification process regulation of phosphate metabolic process positive regulation of protein phosphorylation positive regulation of phosphorus metabolic process regulation of protein metabolic process regulation of phosphorus metabolic process regulation of phosphorylation regulation of developmental process angiogenesis regulation of vasculature development tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development regulation of multicellular organismal development blood vessel morphogenesis tube development negative regulation of blood vessel morphogenesis negative regulation of developmental process negative regulation of angiogenesis vasculature development circulatory system development negative regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis negative regulation of multicellular organismal process hematopoietic progenitor cell differentiation response to organic cyclic compound apoptotic mitochondrial changes mitochondrial outer membrane permeabilization involved in programmed cell death mitochondrial membrane organization positive regulation of mitochondrial membrane permeability involved in apoptotic process positive regulation of mitochondrial membrane permeability positive regulation of membrane permeability regulation of biological quality regulation of mitochondrial membrane permeability mitochondrial transport mitochondrion organization membrane organization organelle organization regulation of membrane permeability regulation of mitochondrial membrane permeability involved in apoptotic process vacuole organization intermediate filament-based process neurofilament cytoskeleton organization cytoskeleton organization intermediate filament cytoskeleton organization response to osmotic stress cellular response to anisomycin response to anisomycin cellular response to virus biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to external biotic stimulus response to virus heart development heart morphogenesis outflow tract morphogenesis	protein-containing complex intracellular anatomical structure catalytic complex intracellular membraneless organelle chromatin chromosome transferase complex histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex intracellular organelle cellular anatomical structure organelle membraneless organelle protein-containing complex intracellular anatomical structure catalytic complex intracellular membraneless organelle chromatin chromosome transferase complex histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex intracellular organelle cellular anatomical structure organelle membraneless organelle protein acetyltransferase complex intracellular protein-containing complex cytoplasm membrane-bounded organelle mitochondrial membrane mitochondrion membrane organelle outer membrane intracellular membrane-bounded organelle organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane RNA polymerase II transcription regulator complex nucleus nuclear protein-containing complex transcription regulator complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen site of double-strand break site of DNA damage

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003527	Mitogen-activated protein (MAP) kinase, conserved site	Conserved Site
A	IPR000719	Protein kinase domain	Domain
A	IPR017441	Protein kinase, ATP binding site	Binding Site
A	IPR038784	Mitogen-activated protein kinase 14	Family
A	IPR050117	Mitogen-activated protein kinase	Family
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A	IPR008352	Mitogen-activated protein (MAP) kinase p38-like	Family
B	IPR013087	Zinc finger C2H2-type	Domain
B	IPR016378	Transcription factor cyclic AMP-dependent, CRE-BP1-type	Family
B	IPR036236	Zinc finger C2H2 superfamily	Homologous Superfamily
B	IPR004827	Basic-leucine zipper domain	Domain
B	IPR046347	Basic-leucine zipper domain superfamily	Homologous Superfamily
B	IPR051027	Basic leucine zipper (bZIP) transcription factors	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q16539	cardiomyopathy chronic myelogenous leukemia, BCR-ABL1 positive liver cancer cholestasis lung benign neoplasm lymphoplasmacytic lymphoma Malignant neoplasm of lung attention deficit hyperactivity disorder, inattentive type ovarian cancer primary biliary cholangitis coronary artery disease rheumatoid arthritis subependymal giant cell astrocytoma Gaucher disease liver neoplasm cardiomyopathy chronic myelogenous leukemia, BCR-ABL1 positive liver cancer cholestasis lung benign neoplasm lymphoplasmacytic lymphoma Malignant neoplasm of lung attention deficit hyperactivity disorder, inattentive type ovarian cancer primary biliary cholangitis coronary artery disease rheumatoid arthritis subependymal giant cell astrocytoma Gaucher disease liver neoplasm lung cancer malignant ependymoma atypical teratoid rhabdoid tumor myocardial ischemia pancreatic ductal adenocarcinoma pilocytic astrocytoma progressive supranuclear palsy schizophrenia extrahepatic cholestasis glioblastoma large cell medulloblastoma lung adenocarcinoma malignant glioma medulloblastoma osteosarcoma plantar wart psoriasis spondyloarthropathy gastric adenocarcinoma
B	Pharos: P15336	cancer atypical teratoid rhabdoid tumor Disease Exacerbation osteosarcoma benign neoplasm medulloblastoma ovarian cancer large cell medulloblastoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	PTR	Parent Component: TYR RESID: AA0039 PSI-MOD : O4'-phospho-L-tyrosine MOD:00048
A	TPO	Parent Component: THR RESID: AA0039 , AA0038 PSI-MOD : O4'-phospho-L-tyrosine MOD:00048 , O-phospho-L-threonine MOD:00047

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.