7A61
Crystal structure of KPC-2 with hydrolyzed faropenem (ring-open form)
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | Peptidase_S11_1st_1 | e7a61A1 | A: alpha complex topology | X: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology) | H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology) | T: alpha-helical domain in beta-lactamase/transpeptidase-like proteins | F: Peptidase_S11_1st_1 | ECOD (1.6) |
A | PQQ_like,Beta-lactamase2 | e7a61A2 | A: a+b three layers | X: Profilin-like | H: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology) | T: a+b domain in beta-lactamase/transpeptidase-like proteins | F: PQQ_like,Beta-lactamase2 | ECOD (1.6) |
AMR Gene Family: CARD Annotation CARD Database Homepage
Chains | Accession | Gene Family | Drug Class | Resistance Machanism | Provenance Source (Version) |
---|---|---|---|---|---|
ARO:3000059 | KPC beta-lactamase | monobactam, carbapenem, cephalosporin, penam | antibiotic inactivation | CARD (3.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF13354 | Beta-lactamase enzyme family (Beta-lactamase2) | Beta-lactamase enzyme family | This is the catalytic domain of class A beta-lactamases [1]. It is closely related to Beta-lactamase, Pfam:PF00144, the serine beta-lactamase-like superfamily, which contains the distantly related Pfam:PF00905 and PF00768 D-alanyl-D-alanine carboxype ... | Domain | |
PF00144 | Beta-lactamase (Beta-lactamase) | Beta-lactamase | This family appears to be distantly related to Pfam:PF00905 and PF00768 D-alanyl-D-alanine carboxypeptidase. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR045155 | Beta-lactamase class A, catalytic domain | Domain | |
IPR012338 | Beta-lactamase/transpeptidase-like | Homologous Superfamily | |
IPR000871 | Beta-lactamase, class-A | Family |