7AAI

Crystal structure of Human serum albumin in complex with perfluorooctanoic acid (PFOA) at 2.10 Angstrom Resolution

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth AAA]	SCOP2B Superfamily	Serum albumin-like	8033044	3001552	SCOP2B (2022-06-29)
A [auth AAA]	SCOP2B Superfamily	Serum albumin-like	8033047	3001552	SCOP2B (2022-06-29)
A [auth AAA]	SCOP2B Superfamily	Serum albumin-like	8033045	3001552	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth AAA]	Serum_albumin	e7aaiAAA2	A: alpha complex topology	X: Serum albumin-like (From Topology)	H: Serum albumin-like (From Topology)	T: Serum albumin-like	F: Serum_albumin	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth AAA]	PF00273	Serum albumin family (Serum_albumin)	Serum albumin family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth AAA]	Albumin	antioxidant activity vitamin binding vitamin B6 binding pyridoxal phosphate binding ion binding binding organic cyclic compound binding anion binding heterocyclic compound binding small molecule binding fatty acid binding organic acid binding lipid binding carboxylic acid binding antioxidant activity vitamin binding vitamin B6 binding pyridoxal phosphate binding ion binding binding organic cyclic compound binding anion binding heterocyclic compound binding small molecule binding fatty acid binding organic acid binding lipid binding carboxylic acid binding monocarboxylic acid binding protein binding exogenous protein binding cation binding transition metal ion binding copper ion binding metal ion binding toxic substance binding macrolide binding enterobactin binding protein-folding chaperone binding DNA binding nucleic acid binding identical protein binding	regulation of biological process regulation of cellular process regulation of mitochondrial depolarization negative regulation of membrane depolarization biological regulation negative regulation of biological process mitochondrial depolarization regulation of membrane depolarization regulation of mitochondrial membrane potential membrane depolarization cellular process regulation of biological quality negative regulation of mitochondrial depolarization regulation of membrane potential regulation of biological process regulation of cellular process regulation of mitochondrial depolarization negative regulation of membrane depolarization biological regulation negative regulation of biological process mitochondrial depolarization regulation of membrane depolarization regulation of mitochondrial membrane potential membrane depolarization cellular process regulation of biological quality negative regulation of mitochondrial depolarization regulation of membrane potential cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus cellular response to stress response to stress response to starvation cellular response to calcium ion starvation cellular response to starvation	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm protein-containing complex blood microparticle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm protein-containing complex blood microparticle intracellular organelle Golgi apparatus intracellular membrane-bounded organelle endomembrane system membrane-enclosed lumen intracellular organelle lumen endoplasmic reticulum lumen organelle lumen endoplasmic reticulum vesicle lumen intracellular vesicle cytoplasmic vesicle lumen secretory granule lumen cytoplasmic vesicle secretory granule secretory vesicle platelet alpha granule platelet alpha granule lumen nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth AAA]	IPR020857	Serum albumin, conserved site	Conserved Site
A [auth AAA]	IPR000264	ALB/AFP/VDB	Family
A [auth AAA]	IPR014760	Serum albumin, N-terminal	Domain
A [auth AAA]	IPR020858	Serum albumin-like	Homologous Superfamily
A [auth AAA]	IPR021177	Serum albumin/Alpha-fetoprotein/Afamin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth AAA]	Pharos: P02768	thrombocytopenia pancreatitis Stevens-Johnson syndrome allergic disease angioedema hyperthyroxinemia, familial dysalbuminemic myopathy heart disease hemolytic-uremic syndrome membranous glomerulonephritis adult acute respiratory distress syndrome uveitis nephrotic syndrome glomerulonephritis kidney disease thrombocytopenia pancreatitis Stevens-Johnson syndrome allergic disease angioedema hyperthyroxinemia, familial dysalbuminemic myopathy heart disease hemolytic-uremic syndrome membranous glomerulonephritis adult acute respiratory distress syndrome uveitis nephrotic syndrome glomerulonephritis kidney disease HIV infectious disease echinococcosis hypertensive disorder interstitial nephritis Pain diabetic peripheral angiopathy melancholia urticaria nephrosis congenital analbuminemia serum sickness keloid hepatitis brain disease membranoproliferative glomerulonephritis cardiovascular disease endogenous depression cerebrovascular disorder anuria nephritis aseptic meningitis congestive heart failure azoospermia brain ischemia acute liver failure epilepsy poisoning chronic kidney disease proteinuria cirrhosis of liver neurodegenerative disease asthma respiratory failure influenza coronary artery disease dense deposit disease non-alcoholic fatty liver disease autoimmune disease bone marrow disease hepatitis C virus infection toxic epidermal necrolysis lymphatic system disease pancreatic intraductal papillary-mucinous neoplasm breast disease type IV hypersensitivity disease perennial allergic rhinitis cancer Ehlers-Danlos syndrome, arthrochalasis type peritonitis primary biliary cholangitis arthritic joint disease protein-energy malnutrition chronic obstructive pulmonary disease gastric neoplasm psoriasis inborn carbohydrate metabolic disorder COVID-19 neurotic disorder atherosclerosis respiratory system disease inherited lipid metabolism disorder obesity disorder diabetic kidney disease diabetic retinopathy brain injury liver disease pancreatic ductal adenocarcinoma hereditary diffuse gastric adenocarcinoma breast cancer tuberculosis pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia peripheral neuropathy hyperglycemia muscle tissue disease pneumonia esophageal varices primary membranoproliferative glomerulonephritis cholestasis protein-losing enteropathy hypotensive disorder inflammatory bowel disease dementia heart failure depressive disorder hepatic encephalopathy skin disease hepatitis B virus infection stomach disease leukopenia diarrheal disease pancreas disease thrombotic disease lung adenocarcinoma malignant pancreatic neoplasm acute kidney failure pancreatic intraductal papillary-mucinous carcinoma hereditary hyperbilirubinemia breast carcinoma type 2 diabetes mellitus drug-induced liver injury C1 inhibitor deficiency urinary tract infection metabolic acidosis peripheral vascular disease hyperparathyroidism varicose disease muscular disease anemia extrahepatic cholestasis prostate carcinoma hypoglycemia nephrosclerosis gastric cancer idiopathic membranous glomerulonephritis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.