7ACC

human GTP cyclohydrolase I feedback regulatory protein (GFRP)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d7acca_	Alpha and beta proteins (a+b)	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d7accb_	Alpha and beta proteins (a+b)	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d7accc1	Alpha and beta proteins (a+b)	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d7accc2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d7accd_	Alpha and beta proteins (a+b)	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d7accf_	Alpha and beta proteins (a+b)	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d7accg1	Alpha and beta proteins (a+b)	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d7accg2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d7acch1	Alpha and beta proteins (a+b)	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d7acch2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
I	d7acci_	Alpha and beta proteins (a+b)	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
J	d7accj_	Alpha and beta proteins (a+b)	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d7acce1	Alpha and beta proteins (a+b)	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d7acce2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8102140	3000919	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8102140	3000919	SCOP2B (2022-06-29)
C	SCOP2 Family	GTP cyclohydrolase I feedback regulatory protein, GFRP	8102139	4003468	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8102140	3000919	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8102140	3000919	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8102140	3000919	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8102140	3000919	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8102140	3000919	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8102140	3000919	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8102140	3000919	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8102140	3000919	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	GFRP	e7accA1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)
B	GFRP	e7accB1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)
C	GFRP	e7accC1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)
D	GFRP	e7accD1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)
F	GFRP	e7accF1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)
G	GFRP	e7accG1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)
H	GFRP	e7accH1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)
I	GFRP	e7accI1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)
J	GFRP	e7accJ1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)
E	GFRP	e7accE1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	PF06399	GTP cyclohydrolase I feedback regulatory protein (GFRP) (GFRP)	GTP cyclohydrolase I feedback regulatory protein (GFRP)	Tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids regulates its own synthesis in via feedback inhibition of GTP cyclohydrolase I. This mechanism is mediated by the regulatory subunit called GTP cyclohydrolase I f ...	Tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids regulates its own synthesis in via feedback inhibition of GTP cyclohydrolase I. This mechanism is mediated by the regulatory subunit called GTP cyclohydrolase I feedback regulatory protein (GFRP) [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	GTP cyclohydrolase 1 feedback regulatory protein	protein binding binding GTP cyclohydrolase binding enzyme binding	regulation of biosynthetic process regulation of biological process regulation of cellular process negative regulation of metabolic process biological regulation negative regulation of biological process biosynthetic process negative regulation of biosynthetic process negative regulation of cellular process metabolic process cellular process regulation of metabolic process regulation of nitric oxide biosynthetic process reactive nitrogen species metabolic process regulation of biosynthetic process regulation of biological process regulation of cellular process negative regulation of metabolic process biological regulation negative regulation of biological process biosynthetic process negative regulation of biosynthetic process negative regulation of cellular process metabolic process cellular process regulation of metabolic process regulation of nitric oxide biosynthetic process reactive nitrogen species metabolic process nitric oxide metabolic process nitric oxide biosynthetic process regulation of nitric oxide metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection membrane-bounded organelle pigment granule intracellular vesicle intracellular membrane-bounded organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection membrane-bounded organelle pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle vesicle nuclear membrane membrane nucleus endomembrane system organelle envelope nuclear envelope organelle membrane membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR036717	GFRP superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR009112	GTP cyclohydrolase I, feedback regulatory protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	Pharos: P30047	Liver Cirrhosis, Experimental pancreatic intraductal papillary-mucinous neoplasm non-small cell lung carcinoma psoriasis pancreatic ductal adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.