Annotations: 7B8U

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PAE	e7b8uA1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: PAE	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Palmitoleoyl-protein carboxylesterase NOTUM	phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity phospholipase C activity carboxylic ester hydrolase activity hydrolase activity catalytic activity phospholipase activity lipase activity palmitoleyl hydrolase activity	developmental process multicellular organism development multicellular organismal process skeletal system development anatomical structure development animal organ development bone development system development cellular response to stimulus regulation of cellular process response to stimulus signaling negative regulation of signaling regulation of canonical Wnt signaling pathway developmental process multicellular organism development multicellular organismal process skeletal system development anatomical structure development animal organ development bone development system development cellular response to stimulus regulation of cellular process response to stimulus signaling negative regulation of signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication negative regulation of Wnt signaling pathway negative regulation of cellular process signal transduction Wnt signaling pathway regulation of biological process regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway negative regulation of response to stimulus biological regulation negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway regulation of response to stimulus regulation of cell communication cellular process catabolic process lipoprotein metabolic process primary metabolic process protein catabolic process macromolecule deacylation protein depalmitoleylation macromolecule catabolic process protein deacylation macromolecule modification metabolic process protein metabolic process macromolecule metabolic process protein modification process lipoprotein catabolic process regulation of multicellular organismal development regulation of developmental process bone mineralization regulation of biomineral tissue development regulation of bone mineralization tissue development ossification biomineral tissue development regulation of multicellular organismal process regulation of ossification	membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle cellular anatomical structure organelle lumen organelle endoplasmic reticulum cytoplasm extracellular region