7CL1
Human SIRT6 in complex with allosteric activator MDL-801 (3.2A)
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | SIR2_1st | e7cl1A2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: DHS-like NAD/FAD-binding domain | F: SIR2_1st | ECOD (1.6) |
A | KOG1905 | e7cl1A1 | A: few secondary structure elements | X: Rubredoxin-like | H: Rubredoxin-related | T: Rubredoxin-related | F: KOG1905 | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF02146 | Sir2 family (SIR2) | Sir2 family | - | Family |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR003000 | Sirtuin family | Family | |
IPR029035 | DHS-like NAD/FAD-binding domain superfamily | Homologous Superfamily | |
IPR026590 | Sirtuin family, catalytic core domain | Domain | |
IPR050134 | NAD-dependent sirtuin protein deacylases | Family |
Pharos: Disease Associations Pharos Homepage Annotation
Chains | Drug Target   | Associated Disease |
---|---|---|
Q8N6T7 | :