Annotations: 7D4B

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d7d4bb_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	(Lama glama ) [TaxId: 9844 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	TNFR_c6	e7d4bA2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFR_c6	ECOD (1.6)
A	TNFRSF5	e7d4bA3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF5	ECOD (1.6)
A	TNFRSF14	e7d4bA1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF14	ECOD (1.6)
B	V-set_8	e7d4bB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B	Heavy Chain	IGHV1	-	tumor necrosis factor receptor superfamily member 9	SAbDab (2024-11-15)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00020	TNFR/NGFR cysteine-rich region (TNFR_c6)	TNFR/NGFR cysteine-rich region	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Tumor necrosis factor receptor superfamily member 9	molecular transducer activity signaling receptor activity	cellular process apoptotic process cell death programmed cell death negative regulation of cell population proliferation regulation of biological process cell population proliferation regulation of cellular process regulation of cell population proliferation negative regulation of cellular process biological regulation negative regulation of biological process multicellular organismal process cellular developmental process cellular process apoptotic process cell death programmed cell death negative regulation of cell population proliferation regulation of biological process cell population proliferation regulation of cellular process regulation of cell population proliferation negative regulation of cellular process biological regulation negative regulation of biological process multicellular organismal process cellular developmental process regulation of leukocyte activation immature T cell proliferation in thymus regulation of cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte proliferation leukocyte activation T cell differentiation in thymus T cell activation cell differentiation lymphocyte proliferation anatomical structure development regulation of immature T cell proliferation regulation of multicellular organismal process regulation of immune system process T cell differentiation T cell proliferation regulation of lymphocyte proliferation developmental process regulation of leukocyte proliferation hemopoiesis cell activation regulation of T cell activation immature T cell proliferation regulation of immature T cell proliferation in thymus regulation of T cell proliferation mononuclear cell proliferation immune system process regulation of mononuclear cell proliferation regulation of lymphocyte activation leukocyte differentiation	cell periphery cellular anatomical structure plasma membrane membrane cell surface external side of plasma membrane side of membrane
B	anti-4-1BB VHH	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
A	IPR001368	TNFR/NGFR cysteine-rich region	Domain
A	IPR020413	Tumour necrosis factor receptor 9	Family
A	IPR034020	Tumour necrosis factor receptor 9, N-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q07011	ulcerative colitis malignant colon neoplasm medulloblastoma tuberculosis benign colon neoplasm colorectal cancer gastric cancer hereditary diffuse gastric adenocarcinoma kidney cancer lung cancer Malignant neoplasm of kidney psoriasis cancer Crohn disease gastric neoplasm ulcerative colitis malignant colon neoplasm medulloblastoma tuberculosis benign colon neoplasm colorectal cancer gastric cancer hereditary diffuse gastric adenocarcinoma kidney cancer lung cancer Malignant neoplasm of kidney psoriasis cancer Crohn disease gastric neoplasm inflammatory bowel disease kidney neoplasm lymphatic system disease rheumatoid arthritis colonic neoplasm cutaneous lupus erythematosus hematologic disease interstitial cystitis lung adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.