7KZE

Substrate-dependent divergence of leukotriene A4 hydrolase aminopeptidase activity

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Metalloproteases (zincins), catalytic domain	8038934	3001975	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ARM repeat-like	8038928	3000116	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Leukotriene A4 hydrolase N-terminal domain	8038930	3000390	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ARM repeat-like	8038928	3000116	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Leukotriene A4 hydrolase N-terminal domain	8038930	3000390	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Metalloproteases (zincins), catalytic domain	8038934	3001975	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Leukotriene A4 hydrolase N-terminal domain	8038930	3000390	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Metalloproteases (zincins), catalytic domain	8038934	3001975	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ARM repeat-like	8038928	3000116	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Peptidase_M1_2	e7kzeA2	A: beta sandwiches	X: Baculovirus p35 protein-related (From Topology)	H: Baculovirus p35 protein-related (From Topology)	T: Baculovirus p35 protein-related	F: Peptidase_M1_2	ECOD (1.6)
A	Leuk-A4-hydro_C	e7kzeA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Leuk-A4-hydro_C	ECOD (1.6)
A	Peptidase_M1_1	e7kzeA3	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Peptidase_M1_1	ECOD (1.6)
C	Peptidase_M1_2	e7kzeC1	A: beta sandwiches	X: Baculovirus p35 protein-related (From Topology)	H: Baculovirus p35 protein-related (From Topology)	T: Baculovirus p35 protein-related	F: Peptidase_M1_2	ECOD (1.6)
C	Leuk-A4-hydro_C	e7kzeC3	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Leuk-A4-hydro_C	ECOD (1.6)
C	Peptidase_M1_1	e7kzeC2	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Peptidase_M1_1	ECOD (1.6)
B	Peptidase_M1_2	e7kzeB3	A: beta sandwiches	X: Baculovirus p35 protein-related (From Topology)	H: Baculovirus p35 protein-related (From Topology)	T: Baculovirus p35 protein-related	F: Peptidase_M1_2	ECOD (1.6)
B	Leuk-A4-hydro_C	e7kzeB2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Leuk-A4-hydro_C	ECOD (1.6)
B	Peptidase_M1_1	e7kzeB1	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Peptidase_M1_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF09127	Leukotriene A4 hydrolase, C-terminal (Leuk-A4-hydro_C)	Leukotriene A4 hydrolase, C-terminal	-	Repeat
A, B, C	PF01433	Peptidase family M1 domain (Peptidase_M1)	Peptidase family M1 domain	Members of this family are aminopeptidases. The members differ widely in specificity, hydrolysing acidic, basic or neutral N-terminal residues. This family includes leukotriene-A4 hydrolase Swiss:P09960, this enzyme also has an aminopeptidase activ ...	Members of this family are aminopeptidases. The members differ widely in specificity, hydrolysing acidic, basic or neutral N-terminal residues. This family includes leukotriene-A4 hydrolase Swiss:P09960, this enzyme also has an aminopeptidase activity [1].	Domain
A, B, C	PF17900	Peptidase M1 N-terminal domain (Peptidase_M1_N)	Peptidase M1 N-terminal domain	This domain is found at the N-terminus of aminopeptidases from the M1 family.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Leukotriene A-4 hydrolase	peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity RNA binding binding organic cyclic compound binding nucleic acid binding metallopeptidase activity aminopeptidase activity metalloaminopeptidase activity exopeptidase activity metalloexopeptidase activity leukotriene-A4 hydrolase activity peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity RNA binding binding organic cyclic compound binding nucleic acid binding metallopeptidase activity aminopeptidase activity metalloaminopeptidase activity exopeptidase activity metalloexopeptidase activity leukotriene-A4 hydrolase activity ether hydrolase activity hydrolase activity, acting on ether bonds tripeptidase activity tripeptide aminopeptidase activity epoxide hydrolase activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	icosanoid metabolic process leukotriene metabolic process oxoacid metabolic process small molecule biosynthetic process cellular biosynthetic process cellular metabolic process leukotriene biosynthetic process carboxylic acid metabolic process organic acid metabolic process organic acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process icosanoid biosynthetic process small molecule metabolic process icosanoid metabolic process leukotriene metabolic process oxoacid metabolic process small molecule biosynthetic process cellular biosynthetic process cellular metabolic process leukotriene biosynthetic process carboxylic acid metabolic process organic acid metabolic process organic acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process icosanoid biosynthetic process small molecule metabolic process metabolic process cellular process cellular catabolic process catabolic process peptide metabolic process peptide catabolic process response to stimulus response to hormone response to chemical response to endogenous stimulus response to peptide hormone response to oxygen-containing compound response to nitrogen compound developmental process multicellular organismal process epithelium development cellular developmental process tube development animal organ development respiratory tube development lung epithelium development type I pneumocyte differentiation tissue development epithelial cell differentiation lung epithelial cell differentiation multicellular organism development lung cell differentiation cell differentiation anatomical structure development lung development respiratory system development system development primary metabolic process lipid metabolic process response to metal ion response to zinc ion protein metabolic process macromolecule metabolic process proteolysis	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol membrane-enclosed lumen extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol membrane-enclosed lumen intracellular vesicle ficolin-1-rich granule intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle organelle lumen cytoplasmic vesicle ficolin-1-rich granule lumen secretory granule secretory vesicle nucleus nucleoplasm nuclear lumen tertiary granule lumen tertiary granule

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR034015	Aminopeptidase, leukotriene A4 hydrolase-like	Family
A, B, C	IPR001930	Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase	Family
A, B, C	IPR016024	Armadillo-type fold	Homologous Superfamily
A, B, C	IPR012777	Leukotriene A4 hydrolase/leucine aminopeptidase	Family
A, B, C	IPR042097	Aminopeptidase N-like , N-terminal domain superfamliy	Homologous Superfamily
A, B, C	IPR049980	Leukotriene A4 hydrolase-like, catalytic domain	Domain
A, B, C	IPR015211	Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal	Domain
A, B, C	IPR038502	Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily	Homologous Superfamily
A, B, C	IPR027268	Peptidase M4/M1, CTD superfamily	Homologous Superfamily
A, B, C	IPR014782	Peptidase M1, membrane alanine aminopeptidase	Domain
A, B, C	IPR045357	Aminopeptidase N-like , N-terminal domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: P09960	atherosclerosis Liver Cirrhosis, Experimental squamous cell carcinoma acute myeloid leukemia cutaneous melanoma hypertensive disorder lung carcinoma ovarian cancer tuberculosis arteriosclerosis disorder depressive disorder lymphoplasmacytic lymphoma non-small cell lung carcinoma small intestine neuroendocrine neoplasm astrocytic tumor atherosclerosis Liver Cirrhosis, Experimental squamous cell carcinoma acute myeloid leukemia cutaneous melanoma hypertensive disorder lung carcinoma ovarian cancer tuberculosis arteriosclerosis disorder depressive disorder lymphoplasmacytic lymphoma non-small cell lung carcinoma small intestine neuroendocrine neoplasm astrocytic tumor malignant mesothelioma osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.