7LSQ

The Crystal Structure of Q108K:K40E:T53A:R58W:Q38F:Q4F:Y19W Mutant of HCRBPII Bound with LizFluor Chromophore Showing Excited State Intermolecular Proton Transfer

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Lipocalins	8062823	3001332	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Lipocalins	8062823	3001332	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Lipocalins	8062823	3001332	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Lipocalins	8062823	3001332	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Lipocalin_7	e7lsqA1	A: beta barrels	X: Lipocalins/Streptavidin	H: Lipocalins (From Topology)	T: Lipocalins	F: Lipocalin_7	ECOD (1.6)
C	Lipocalin_7	e7lsqC1	A: beta barrels	X: Lipocalins/Streptavidin	H: Lipocalins (From Topology)	T: Lipocalins	F: Lipocalin_7	ECOD (1.6)
D	Lipocalin_7	e7lsqD1	A: beta barrels	X: Lipocalins/Streptavidin	H: Lipocalins (From Topology)	T: Lipocalins	F: Lipocalin_7	ECOD (1.6)
B	Lipocalin_7	e7lsqB1	A: beta barrels	X: Lipocalins/Streptavidin	H: Lipocalins (From Topology)	T: Lipocalins	F: Lipocalin_7	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00061	Lipocalin / cytosolic fatty-acid binding protein family (Lipocalin)	Lipocalin / cytosolic fatty-acid binding protein family	Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid ...	Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Retinol-binding protein 2	vitamin binding binding retinal binding isoprenoid binding retinoid binding lipid binding small molecule binding fatty acid binding organic acid binding ion binding anion binding carboxylic acid binding monocarboxylic acid binding alcohol binding vitamin binding binding retinal binding isoprenoid binding retinoid binding lipid binding small molecule binding fatty acid binding organic acid binding ion binding anion binding carboxylic acid binding monocarboxylic acid binding alcohol binding retinol binding	organic anion transport carboxylic acid transport transport lipid localization lipid transport establishment of localization organic acid transport localization monocarboxylic acid transport fatty acid transport macromolecule localization developmental process epidermis development anatomical structure development organic anion transport carboxylic acid transport transport lipid localization lipid transport establishment of localization organic acid transport localization monocarboxylic acid transport fatty acid transport macromolecule localization developmental process epidermis development anatomical structure development tissue development diterpenoid metabolic process fat-soluble vitamin metabolic process cellular metabolic process primary metabolic process vitamin A metabolic process vitamin metabolic process retinoid metabolic process cellular lipid metabolic process metabolic process cellular process small molecule metabolic process terpenoid metabolic process isoprenoid metabolic process lipid metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR000463	Cytosolic fatty-acid binding	Domain
A, B, C, D	IPR012674	Calycin	Homologous Superfamily
A, B, C, D	IPR031259	Intracellular lipid binding protein	Family
A, B, C, D	IPR000566	Lipocalin/cytosolic fatty-acid binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P50120	psoriasis ulcerative colitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.