7MKS

Crystal structure of the GH12 domain from Acidothermus cellulolyticus GuxA bound to cellobiose

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth AAA]	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8107556	3000120	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth AAA]	Glyco_hydro_12	e7mksAAA1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Glyco_hydro_12	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth AAA]	PF01670	Glycosyl hydrolase family 12 (Glyco_hydro_12)	Glycosyl hydrolase family 12	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth AAA]	Glycoside hydrolase, family 6	hydrolase activity, acting on glycosyl bonds cellulase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity catalytic activity binding polysaccharide binding cellulose binding carbohydrate binding cation binding ion binding metal ion binding small molecule binding	carbohydrate metabolic process catabolic process glucan catabolic process beta-glucan metabolic process carbohydrate catabolic process primary metabolic process macromolecule catabolic process polysaccharide metabolic process glucan metabolic process beta-glucan catabolic process polysaccharide catabolic process metabolic process cellulose catabolic process macromolecule metabolic process carbohydrate metabolic process catabolic process glucan catabolic process beta-glucan metabolic process carbohydrate catabolic process primary metabolic process macromolecule catabolic process polysaccharide metabolic process glucan metabolic process beta-glucan catabolic process polysaccharide catabolic process metabolic process cellulose catabolic process macromolecule metabolic process cellulose metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth AAA]	IPR012291	CBM2, carbohydrate-binding domain superfamily	Homologous Superfamily
A [auth AAA]	IPR036966	Carbohydrate-binding module 3 superfamily	Homologous Superfamily
A [auth AAA]	IPR001956	Carbohydrate-binding module 3	Domain
A [auth AAA]	IPR003961	Fibronectin type III	Domain
A [auth AAA]	IPR013319	Glycoside hydrolase family 11/12	Homologous Superfamily
A [auth AAA]	IPR008965	CBM2/CBM3, carbohydrate-binding domain superfamily	Homologous Superfamily
A [auth AAA]	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A [auth AAA]	IPR016288	1, 4-beta cellobiohydrolase	Family
A [auth AAA]	IPR036434	1, 4-beta cellobiohydrolase superfamily	Homologous Superfamily
A [auth AAA]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A [auth AAA]	IPR001524	Glycoside hydrolase, family 6, conserved site	Conserved Site
A [auth AAA]	IPR001919	Carbohydrate-binding type-2 domain	Domain
A [auth AAA]	IPR002594	Glycoside hydrolase family 12	Family
A [auth AAA]	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.