7N9G

Crystal structure of the Abl 1b Kinase domain in complex with Dasatinib and Imatinib

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Protein kinase-like (PK-like)	8091373	3000066	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Protein kinase-like (PK-like)	8091373	3000066	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Protein kinase-like (PK-like)	8091373	3000066	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Pkinase_Tyr	e7n9gA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
B	Pkinase_Tyr	e7n9gB1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
C	Pkinase_Tyr	e7n9gC1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF07714	Protein tyrosine and serine/threonine kinase (PK_Tyr_Ser-Thr)	Protein tyrosine and serine/threonine kinase	Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosph ...	Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity [1]; Serine/threonine-protein kinases, tyrosine-protein kinases, and dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins). This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. It does not include the catalytic domain of dual specificity kinases.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Tyrosine-protein kinase ABL1	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding cation binding manganese ion binding transition metal ion binding ion binding metal ion binding small molecule binding protein tyrosine kinase activity catalytic activity, acting on a protein cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding cation binding manganese ion binding transition metal ion binding ion binding metal ion binding small molecule binding protein tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups SH3 domain binding protein domain specific binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding DNA binding nucleic acid binding delta-catenin binding non-membrane spanning protein tyrosine kinase activity signaling receptor binding ephrin receptor binding kinase binding enzyme binding protein kinase binding mitogen-activated protein kinase binding DNA secondary structure binding four-way junction DNA binding bubble DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding magnesium ion binding adenylyltransferase activity nicotinate-nucleotide adenylyltransferase activity nucleotidyltransferase activity neuropilin binding SNARE binding syntaxin binding phosphoprotein binding phosphotyrosine residue binding protein phosphorylated amino acid binding proline-rich region binding actin monomer binding SH2 domain binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity protein kinase C binding	negative regulation of long-term synaptic potentiation positive regulation of cell communication regulation of cellular process modulation of chemical synaptic transmission signaling positive regulation of biological process negative regulation of biological process cell communication long-term synaptic potentiation synaptic signaling regulation of biological quality positive regulation of cellular process regulation of synaptic plasticity trans-synaptic signaling negative regulation of long-term synaptic potentiation positive regulation of cell communication regulation of cellular process modulation of chemical synaptic transmission signaling positive regulation of biological process negative regulation of biological process cell communication long-term synaptic potentiation synaptic signaling regulation of biological quality positive regulation of cellular process regulation of synaptic plasticity trans-synaptic signaling regulation of biological process regulation of signaling biological regulation cell-cell signaling positive regulation of synaptic transmission chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of long-term synaptic potentiation regulation of cell communication cellular process positive regulation of signaling response to stimulus response to chemical response to xenobiotic stimulus cellular response to stimulus regulation of DNA recombination regulation of double-strand break repair regulation of cellular response to stress regulation of primary metabolic process negative regulation of DNA repair nucleobase-containing compound metabolic process cellular response to stress response to stress regulation of response to stress negative regulation of double-strand break repair negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process recombinational repair regulation of nucleobase-containing compound metabolic process negative regulation of double-strand break repair via homologous recombination double-strand break repair via homologous recombination DNA repair negative regulation of macromolecule metabolic process double-strand break repair negative regulation of response to stimulus negative regulation of metabolic process DNA recombination primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of DNA repair regulation of double-strand break repair via homologous recombination negative regulation of DNA recombination DNA damage response regulation of response to stimulus metabolic process negative regulation of DNA metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process macromolecule modification protein metabolic process protein modification process myoblast proliferation cell population proliferation regulation of tube diameter multicellular organismal process system process regulation of tube size regulation of system process positive regulation of vasoconstriction circulatory system process regulation of blood circulation vascular process in circulatory system regulation of vasoconstriction positive regulation of multicellular organismal process regulation of multicellular organismal process blood vessel diameter maintenance vasoconstriction blood circulation regulation of anatomical structure size catabolic process autophagy process utilizing autophagic mechanism endothelial cell migration cell migration cell motility platelet-derived growth factor receptor-beta signaling pathway cell surface receptor signaling pathway platelet-derived growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway signal transduction enzyme-linked receptor protein signaling pathway cell adhesion substrate adhesion-dependent cell spreading cell-substrate adhesion positive regulation of signal transduction regulation of signal transduction Wnt signaling pathway, planar cell polarity pathway positive regulation of response to stimulus positive regulation of non-canonical Wnt signaling pathway positive regulation of Wnt signaling pathway non-canonical Wnt signaling pathway Wnt signaling pathway positive regulation of Wnt signaling pathway, planar cell polarity pathway regulation of Wnt signaling pathway, planar cell polarity pathway regulation of Wnt signaling pathway regulation of non-canonical Wnt signaling pathway negative regulation of signaling negative regulation of intracellular signal transduction intracellular signal transduction negative regulation of cell communication regulation of intracellular signal transduction intracellular signaling cassette regulation of MAPK cascade negative regulation of signal transduction negative regulation of ERK1 and ERK2 cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade negative regulation of MAPK cascade developmental process cellular developmental process hemopoiesis DN4 thymocyte differentiation cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell differentiation in thymus T cell activation immune system process cell differentiation anatomical structure development T cell differentiation leukocyte differentiation positive regulation of substrate adhesion-dependent cell spreading regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of substrate adhesion-dependent cell spreading regulation of cell adhesion positive regulation of cell-substrate adhesion regulation of leukocyte differentiation regulation of developmental process regulation of leukocyte activation regulation of cell activation regulation of cell differentiation regulation of cell development regulation of T cell differentiation multicellular organism development regulation of immune system process regulation of lymphocyte differentiation regulation of multicellular organismal development regulation of T cell activation regulation of hemopoiesis regulation of lymphocyte activation regulation of cellular component organization positive regulation of cellular component organization cell-substrate junction assembly positive regulation of cell-substrate junction organization cellular component organization cellular component biogenesis cellular component assembly cell junction assembly regulation of cell-substrate junction organization cellular component organization or biogenesis focal adhesion assembly positive regulation of focal adhesion assembly positive regulation of cellular component biogenesis positive regulation of cell-matrix adhesion regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly cell junction organization cell-matrix adhesion regulation of cell-matrix adhesion cell-substrate junction organization regulation of focal adhesion assembly regulation of cell-substrate junction assembly neuropilin signaling pathway response to oxidative stress cellular response to chemical stimulus cellular response to oxidative stress cellular response to chemical stress negative regulation of cell adhesion cell-cell adhesion negative regulation of cell-cell adhesion regulation of cell-cell adhesion embryonic epithelial tube formation chordate embryonic development tube formation embryo development epithelial tube formation tube morphogenesis primary neural tube formation embryo development ending in birth or egg hatching epithelial tube morphogenesis system development morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium nervous system development tissue development anatomical structure morphogenesis tissue morphogenesis neural tube closure neural tube formation anatomical structure formation involved in morphogenesis tube closure positive regulation of cell population proliferation positive regulation of osteoblast proliferation osteoblast proliferation regulation of cell population proliferation regulation of osteoblast proliferation immune system development spleen development animal organ development hematopoietic or lymphoid organ development RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of protein modification process positive regulation of phosphorylation regulation of catalytic activity regulation of protein phosphorylation positive regulation of protein metabolic process regulation of transferase activity positive regulation of phosphate metabolic process positive regulation of metabolic process positive regulation of molecular function positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process positive regulation of protein kinase activity phosphorus metabolic process positive regulation of protein phosphorylation protein phosphorylation positive regulation of transferase activity positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process positive regulation of catalytic activity regulation of protein kinase activity regulation of molecular function positive regulation of kinase activity activation of protein kinase C activity regulation of kinase activity activation of protein kinase activity regulation of phosphorylation regulation of phosphorus metabolic process regulation of protein binding positive regulation of protein binding regulation of binding positive regulation of microtubule binding regulation of microtubule binding positive regulation of binding B cell proliferation involved in immune response immune response B cell activation B cell proliferation B cell activation involved in immune response cell activation involved in immune response leukocyte proliferation immune effector process mononuclear cell proliferation leukocyte activation involved in immune response lymphocyte proliferation lymphocyte activation involved in immune response cellular response to nitrogen compound response to dopamine cellular response to dopamine response to monoamine cellular response to organic cyclic compound response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound response to catecholamine cellular response to monoamine stimulus cellular response to catecholamine stimulus response to organic cyclic compound regulation of oxidoreductase activity positive regulation of oxidoreductase activity response to endoplasmic reticulum stress positive regulation of canonical NF-kappaB signal transduction positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction regulation of hematopoietic stem cell differentiation stem cell differentiation regulation of stem cell differentiation hematopoietic stem cell differentiation regulation of hematopoietic progenitor cell differentiation hematopoietic progenitor cell differentiation response to epinephrine positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade regulation of cytoskeleton organization regulation of actin filament-based process actin cytoskeleton organization regulation of organelle organization organelle organization regulation of actin cytoskeleton organization actin filament-based process cytoskeleton organization small GTPase-mediated signal transduction regulation of small GTPase mediated signal transduction regulation of Cdc42 protein signal transduction regulation of Rho protein signal transduction Rho protein signal transduction Cdc42 protein signal transduction chromosome organization DNA conformation change protein polymerization actin polymerization or depolymerization actin filament polymerization protein-containing complex organization actin filament organization protein-containing complex assembly supramolecular fiber organization nervous system process neuromuscular process neuromuscular process controlling balance generation of neurons neurogenesis neuron differentiation regulation of modification of synaptic structure regulation of synapse organization regulation of synapse structure or activity synapse organization modification of synaptic structure axon extension regulation of growth axonogenesis regulation of cellular component size developmental growth cell projection organization neuron projection development cell projection morphogenesis neuron projection morphogenesis developmental growth involved in morphogenesis plasma membrane bounded cell projection morphogenesis cell growth cell morphogenesis regulation of axon extension regulation of extent of cell growth regulation of cell size neuron projection extension regulation of developmental growth plasma membrane bounded cell projection organization developmental cell growth growth axon development regulation of cell growth cell morphogenesis involved in neuron differentiation neuron development localization cellular localization establishment of localization in cell establishment of localization regulation of mitochondrial membrane potential membrane depolarization mitochondrial depolarization regulation of membrane potential branching morphogenesis of an epithelial tube angiogenesis regulation of vasculature development positive regulation of developmental process positive regulation of morphogenesis of an epithelium regulation of morphogenesis of an epithelium regulation of anatomical structure morphogenesis blood vessel development regulation of morphogenesis of a branching structure blood vessel morphogenesis positive regulation of angiogenesis regulation of blood vessel branching vasculature development circulatory system development positive regulation of blood vessel branching branching involved in blood vessel morphogenesis positive regulation of vasculature development regulation of angiogenesis morphogenesis of a branching structure morphogenesis of a branching epithelium neuron apoptotic process apoptotic process cell death programmed cell death regulation of neuron projection development dendrite development positive regulation of neuron projection development positive regulation of cell projection organization regulation of cell projection organization positive regulation of dendrite development regulation of dendrite development regulation of plasma membrane bounded cell projection organization behavior learning learning or memory cognition associative learning podocyte apoptotic process epithelial cell apoptotic process regulation of calcium ion transport regulation of localization positive regulation of cation transmembrane transport positive regulation of calcium ion transport intracellular calcium ion homeostasis calcium ion transport positive regulation of monoatomic ion transport positive regulation of monoatomic ion transmembrane transport monoatomic cation homeostasis monoatomic cation transport intracellular monoatomic ion homeostasis regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport inorganic ion transmembrane transport inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol regulation of transmembrane transport chemical homeostasis inorganic ion homeostasis transport homeostatic process monoatomic ion transmembrane transport calcium ion homeostasis regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion metal ion transport maintenance of location in cell regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport intracellular monoatomic cation homeostasis monoatomic ion homeostasis positive regulation of calcium ion transmembrane transport positive regulation of transmembrane transport monoatomic ion transport intracellular chemical homeostasis positive regulation of release of sequestered calcium ion into cytosol regulation of metal ion transport regulation of sequestering of calcium ion calcium ion transmembrane import into cytosol regulation of transport sequestering of calcium ion cellular homeostasis positive regulation of transport regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport negative regulation of endothelial cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death negative regulation of apoptotic process endothelial cell apoptotic process regulation of endothelial cell apoptotic process positive regulation of cell cycle mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle cell cycle regulation of cell cycle immune response-regulating cell surface receptor signaling pathway involved in phagocytosis import into cell immune response-regulating cell surface receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis vesicle-mediated transport immune response-activating signaling pathway Fc receptor signaling pathway immune response-regulating signaling pathway positive regulation of immune response phagocytosis Fc-gamma receptor signaling pathway positive regulation of immune system process immune response-activating cell surface receptor signaling pathway Fc receptor mediated stimulatory signaling pathway regulation of immune response endocytosis activation of immune response positive regulation of organelle organization regulation of actin filament bundle assembly positive regulation of actin filament bundle assembly actin filament bundle organization positive regulation of stress fiber assembly stress fiber assembly regulation of actin filament organization actomyosin structure organization positive regulation of cytoskeleton organization positive regulation of supramolecular fiber organization regulation of stress fiber assembly contractile actin filament bundle assembly regulation of actomyosin structure organization actin filament bundle assembly regulation of supramolecular fiber organization regulation of type II interferon production type II interferon production positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process cytokine production regulation of cytokine production positive regulation of type II interferon production positive regulation of gene expression positive regulation of cytokine production positive regulation of extracellular matrix organization extracellular matrix organization regulation of extracellular matrix organization extracellular structure organization external encapsulating structure organization peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation peptidyl-amino acid modification regulation of peptidyl-tyrosine phosphorylation peptidyl-tyrosine phosphorylation protein autophosphorylation peptidyl-tyrosine autophosphorylation regulation of establishment of T cell polarity regulation of establishment or maintenance of cell polarity establishment of lymphocyte polarity establishment of T cell polarity positive regulation of leukocyte cell-cell adhesion establishment or maintenance of cell polarity leukocyte cell-cell adhesion positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation positive regulation of establishment of T cell polarity positive regulation of leukocyte activation positive regulation of T cell activation establishment of cell polarity regulation of establishment of cell polarity regulation of leukocyte cell-cell adhesion heart development heart growth cardiac muscle tissue development cardiac muscle cell proliferation organ growth striated muscle tissue development muscle cell proliferation cardiac muscle tissue growth muscle tissue development striated muscle cell proliferation mismatch repair regulation of vesicle-mediated transport regulation of endocytosis positive regulation of programmed cell death positive regulation of apoptotic process positive regulation of neuron apoptotic process regulation of neuron apoptotic process cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of cellular response to growth factor stimulus negative regulation of BMP signaling pathway cellular response to endogenous stimulus BMP signaling pathway cellular response to BMP stimulus regulation of BMP signaling pathway response to endogenous stimulus regulation of cellular response to growth factor stimulus response to BMP transforming growth factor beta receptor superfamily signaling pathway response to growth factor negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway cellular senescence ERBB signaling pathway epidermal growth factor receptor signaling pathway alpha-beta T cell differentiation alpha-beta T cell activation protein localization to microtubule cytoskeleton protein localization protein localization to microtubule end protein localization to microtubule plus-end protein localization to microtubule protein localization to cytoplasmic microtubule protein localization to cytoskeleton protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to cytoplasmic microtubule plus-end microspike assembly plasma membrane bounded cell projection assembly cell projection assembly positive regulation of locomotion regulation of cell motility regulation of lymphocyte migration positive regulation of cell migration positive regulation of cell motility regulation of cell migration positive regulation of mononuclear cell migration regulation of mononuclear cell migration locomotion positive regulation of lymphocyte migration regulation of leukocyte migration positive regulation of T cell migration lymphocyte migration positive regulation of leukocyte migration leukocyte migration regulation of locomotion regulation of T cell migration mononuclear cell migration T cell migration positive regulation of actin binding regulation of actin filament binding positive regulation of actin filament binding regulation of actin binding negative regulation of post-translational protein modification regulation of protein ubiquitination negative regulation of catalytic activity negative regulation of ubiquitin-protein transferase activity protein ubiquitination negative regulation of transferase activity negative regulation of protein modification process regulation of ubiquitin-protein transferase activity negative regulation of protein ubiquitination regulation of protein modification by small protein conjugation or removal negative regulation of protein metabolic process negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification negative regulation of molecular function post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal transitional one stage B cell differentiation immature B cell differentiation transitional stage B cell differentiation B cell differentiation neuroepithelial cell differentiation columnar/cuboidal epithelial cell differentiation epithelial cell differentiation positive regulation of DNA-templated transcription transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process cell migration involved in sprouting angiogenesis regulation of blood vessel endothelial cell migration blood vessel endothelial cell migration regulation of endothelial cell migration positive regulation of cell migration involved in sprouting angiogenesis regulation of cell migration involved in sprouting angiogenesis sprouting angiogenesis positive regulation of blood vessel endothelial cell migration positive regulation of endothelial cell migration positive regulation of cytosolic calcium ion concentration B cell receptor signaling pathway antigen receptor-mediated signaling pathway T cell receptor signaling pathway gland development thymus development signal transduction in response to DNA damage response to transforming growth factor beta cellular response to transforming growth factor beta stimulus cerebellum morphogenesis head development hindbrain morphogenesis brain development cerebellum development central nervous system development metencephalon development hindbrain development phospholipase C-inhibiting G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway fibroblast proliferation regulation of fibroblast proliferation positive regulation of fibroblast proliferation integrin-mediated signaling pathway biological process involved in interspecies interaction between organisms response to lipid response to other organism cellular response to lipopolysaccharide response to external stimulus cellular response to molecule of bacterial origin response to lipopolysaccharide response to biotic stimulus cellular response to biotic stimulus response to bacterium cellular response to lipid response to external biotic stimulus response to molecule of bacterial origin astrocyte differentiation gliogenesis glial cell differentiation Bergmann glial cell differentiation regulation of microtubule polymerization or depolymerization microtubule cytoskeleton organization regulation of protein-containing complex assembly microtubule polymerization or depolymerization regulation of microtubule-based process microtubule polymerization regulation of microtubule polymerization regulation of protein polymerization microtubule-based process regulation of microtubule cytoskeleton organization cellular response to hydrogen peroxide response to reactive oxygen species response to hydrogen peroxide cellular response to reactive oxygen species apoptotic signaling pathway intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway regulation of cellular senescence negative regulation of cellular senescence negative regulation of phosphate metabolic process negative regulation of kinase activity negative regulation of protein serine/threonine kinase activity negative regulation of protein kinase activity negative regulation of protein phosphorylation regulation of protein serine/threonine kinase activity negative regulation of phosphorus metabolic process negative regulation of phosphorylation regulation of interleukin-2 production interleukin-2 production positive regulation of interleukin-2 production B cell homeostasis multicellular organismal-level homeostasis leukocyte homeostasis B-1 B cell homeostasis homeostasis of number of cells lymphocyte homeostasis regulation of catabolic process regulation of autophagy activated T cell proliferation T cell proliferation post-embryonic development negative regulation of cell cycle negative regulation of mitotic cell cycle	membrane-bounded organelle intracellular anatomical structure nuclear membrane membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope organelle membrane cytoskeleton membrane-bounded organelle intracellular anatomical structure nuclear membrane membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope organelle membrane cytoskeleton membraneless organelle intracellular membraneless organelle actin cytoskeleton cytoplasm cytosol membrane-enclosed lumen nucleolus intracellular organelle lumen organelle lumen nuclear lumen cell periphery plasma membrane protein-containing complex nuclear body nucleoplasm somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection ruffle cell leading edge perinuclear region of cytoplasm cell body neuronal cell body postsynapse synapse cell junction mitochondrion growth cone axon distal axon site of polarized growth

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
A, B, C	IPR000719	Protein kinase domain	Domain
A, B, C	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B, C	IPR036860	SH2 domain superfamily	Homologous Superfamily
A, B, C	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
A, B, C	IPR008266	Tyrosine-protein kinase, active site	Active Site
A, B, C	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A, B, C	IPR001452	SH3 domain	Domain
A, B, C	IPR035837	Tyrosine-protein kinase ABL, SH2 domain	Domain
A, B, C	IPR000980	SH2 domain	Domain
A, B, C	IPR015015	F-actin binding	Domain
A, B, C	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B, C	IPR050198	Non-receptor tyrosine kinases involved in cell signaling	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: P00519	chronic myelogenous leukemia, BCR-ABL1 positive congenital heart defects and skeletal malformations syndrome Failure to Thrive tubular adenocarcinoma adenocarcinoma liver cancer cancer esophageal cancer granular cell carcinoma breast carcinoma neoplasm of esophagus ovarian cancer cribriform carcinoma dermatofibrosarcoma protuberans abetalipoproteinemia chronic myelogenous leukemia, BCR-ABL1 positive congenital heart defects and skeletal malformations syndrome Failure to Thrive tubular adenocarcinoma adenocarcinoma liver cancer cancer esophageal cancer granular cell carcinoma breast carcinoma neoplasm of esophagus ovarian cancer cribriform carcinoma dermatofibrosarcoma protuberans abetalipoproteinemia hematologic disease astrocytic tumor lung large cell carcinoma Burkitt lymphoma childhood acute lymphoblastic leukemia congenital anemia pancreatic ductal adenocarcinoma congenital heart disease precancerous condition cribriform carcinoma of breast Down syndrome systemic mastocytosis acute lymphoblastic leukemia gastrointestinal stromal tumor idiopathic hypereosinophilic syndrome atypical teratoid rhabdoid tumor breast cancer lymphatic system disease malignant pancreatic neoplasm chronic eosinophilic leukemia medulloblastoma osteosarcoma tuberculosis acute T cell leukemia juvenile dermatomyositis liver neoplasm malignant ependymoma melanoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.