7NED

Thiourocanate hydratase from Paenibacillus sp. Soil724D2 in complex with cofactor NAD+ and urocanate

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d7neda_	Multi-domain proteins (alpha and beta)	Urocanase	Urocanase	automated matches	automated matches	(Paenibacillus sp. Soil724D2 ) [TaxId: 1736392 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Urocanase_C	e7nedA1	A: a+b two layers	X: Glutamine synthetase-like	H: C-terminal domain in urocanase (From Topology)	T: C-terminal domain in urocanase	F: Urocanase_C	ECOD (1.6)
A	Urocanase_N	e7nedA3	A: a+b two layers	X: N-terminal a+b domain in urocanase (Pfam 01175) (From Topology)	H: N-terminal a+b domain in urocanase (Pfam 01175) (From Topology)	T: N-terminal a+b domain in urocanase (Pfam 01175)	F: Urocanase_N	ECOD (1.6)
A	Urocanase	e7nedA2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: Urocanase	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF17392	Urocanase C-terminal domain (Urocanase_C)	Urocanase C-terminal domain	-	Domain
A	PF01175	Urocanase Rossmann-like domain (Urocanase)	Urocanase Rossmann-like domain	-	Domain
A	PF17391	Urocanase N-terminal domain (Urocanase_N)	Urocanase N-terminal domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Urocanate hydratase	urocanate hydratase activity hydro-lyase activity lyase activity catalytic activity carbon-oxygen lyase activity binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding	catabolic process oxoacid metabolic process aromatic amino acid family catabolic process amino acid metabolic process organic acid metabolic process organic acid catabolic process imidazole-containing compound metabolic process alpha-amino acid metabolic process glutamine family amino acid metabolic process cellular catabolic process carboxylic acid catabolic process glutamate metabolic process small molecule metabolic process amino acid catabolic process catabolic process oxoacid metabolic process aromatic amino acid family catabolic process amino acid metabolic process organic acid metabolic process organic acid catabolic process imidazole-containing compound metabolic process alpha-amino acid metabolic process glutamine family amino acid metabolic process cellular catabolic process carboxylic acid catabolic process glutamate metabolic process small molecule metabolic process amino acid catabolic process aromatic amino acid metabolic process L-histidine catabolic process to glutamate and formate L-histidine metabolic process imidazole-containing compound catabolic process cellular metabolic process dicarboxylic acid metabolic process carboxylic acid metabolic process L-amino acid catabolic process primary metabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process L-histidine catabolic process alpha-amino acid catabolic process proteinogenic amino acid catabolic process metabolic process cellular process monocarboxylic acid metabolic process small molecule catabolic process formate metabolic process L-histidine catabolic process to glutamate and formamide amide catabolic process amide metabolic process formamide metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR035400	Urocanase, N-terminal domain	Domain
A	IPR036190	Urocanase superfamily	Homologous Superfamily
A	IPR023637	Urocanase	Family
A	IPR035085	Urocanase, Rossmann-like domain	Domain
A	IPR038364	Urocanase, central domain superfamily	Homologous Superfamily
A	IPR035401	Urocanase, C-terminal domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.