7NZD

Fourth SH3 domain of POSH (Plenty of SH3 Domains protein)

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth AAA]	SH3_1	e7nzdAAA1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth AAA]	PF14604	Variant SH3 domain (SH3_9)	Variant SH3 domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth AAA]	E3 ubiquitin-protein ligase SH3RF1	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity MAP-kinase scaffold activity protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity cation binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity MAP-kinase scaffold activity protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity cation binding ion binding binding metal ion binding small molecule binding	negative regulation of hydrolase activity regulation of cellular process negative regulation of proteolysis regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of programmed cell death negative regulation of endopeptidase activity regulation of primary metabolic process negative regulation of peptidase activity regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of proteolysis proteolysis regulation of endopeptidase activity negative regulation of cellular process negative regulation of hydrolase activity regulation of cellular process negative regulation of proteolysis regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of programmed cell death negative regulation of endopeptidase activity regulation of primary metabolic process negative regulation of peptidase activity regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of proteolysis proteolysis regulation of endopeptidase activity negative regulation of cellular process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of cysteine-type endopeptidase activity regulation of biological process negative regulation of programmed cell death regulation of protein metabolic process regulation of apoptotic process negative regulation of metabolic process regulation of peptidase activity biological regulation negative regulation of molecular function primary metabolic process regulation of macromolecule metabolic process cell death regulation of molecular function negative regulation of apoptotic process regulation of hydrolase activity negative regulation of cysteine-type endopeptidase activity metabolic process cellular process macromolecule metabolic process apoptotic process regulation of metabolic process programmed cell death protein autoubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process positive regulation of metabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process positive regulation of macromolecule metabolic process proteasomal protein catabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process regulation of protein catabolic process cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus positive regulation of JNK cascade regulation of intracellular signal transduction JNK cascade intracellular signaling cassette signal transduction positive regulation of cellular process regulation of signaling positive regulation of MAPK cascade regulation of JNK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication positive regulation of signaling multicellular organismal process regulation of leukocyte differentiation cellular developmental process regulation of developmental process regulation of alpha-beta T cell activation regulation of leukocyte activation regulation of cell activation cell development regulation of CD4-positive, alpha-beta T cell differentiation mononuclear cell differentiation regulation of alpha-beta T cell differentiation regulation of cell differentiation lymphocyte activation lymphocyte differentiation CD4-positive, alpha-beta T cell differentiation regulation of cell development leukocyte activation regulation of T cell differentiation multicellular organism development alpha-beta T cell differentiation T cell activation CD4-positive, alpha-beta T cell activation cell differentiation anatomical structure development alpha-beta T cell activation regulation of multicellular organismal process regulation of immune system process T cell differentiation developmental process regulation of lymphocyte differentiation regulation of multicellular organismal development hemopoiesis cell activation regulation of T cell activation regulation of CD4-positive, alpha-beta T cell activation immune system process regulation of hemopoiesis regulation of lymphocyte activation leukocyte differentiation response to aldosterone response to ketone response to lipid response to endogenous stimulus response to alcohol response to oxygen-containing compound response to mineralocorticoid response to corticosteroid response to hormone response to steroid hormone response to chemical response to organic cyclic compound negative regulation of signaling extrinsic apoptotic signaling pathway negative regulation of cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of apoptotic signaling pathway neuron migration nervous system development generation of neurons neurogenesis cell migration cell motility system development CD8-positive, alpha-beta T cell activation CD8-positive, alpha-beta T cell proliferation leukocyte proliferation regulation of alpha-beta T cell proliferation alpha-beta T cell proliferation lymphocyte proliferation T cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation regulation of CD8-positive, alpha-beta T cell proliferation cell population proliferation regulation of T cell proliferation mononuclear cell proliferation regulation of cell population proliferation regulation of mononuclear cell proliferation regulation of CD8-positive, alpha-beta T cell activation	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system perinuclear region of cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth AAA]	IPR035795	E3 ubiquitin-protein ligase SH3RF1, second SH3 domain	Domain
A [auth AAA]	IPR050384	Endophilin/SH3RF	Family
A [auth AAA]	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A [auth AAA]	IPR035816	SH3RF1/SH3RF3, fourth SH3 domain	Domain
A [auth AAA]	IPR017907	Zinc finger, RING-type, conserved site	Conserved Site
A [auth AAA]	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A [auth AAA]	IPR001452	SH3 domain	Domain
A [auth AAA]	IPR001841	Zinc finger, RING-type	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth AAA]	Pharos: Q7Z6J0	interstitial cystitis malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm large cell medulloblastoma medulloblastoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia malignant ependymoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.