7PG8

NaV_Ae1/Sp1CTD_pore-ANT05 complex

External Resource: Annotation

Domain Annotation: ECOD Classification
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: PDBTM

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth M]	C1-set_4	e7pg8M1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
B [auth M]	V-set	e7pg8M2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
C [auth V]	C1-set_4	e7pg8V2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
C [auth V]	V-set	e7pg8V1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
H [auth A]	C1-set_4	e7pg8A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
H [auth A]	V-set	e7pg8A2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
A [auth P]	C1-set_4	e7pg8P2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
A [auth P]	V-set	e7pg8P1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
D [auth S]	C1-set_4	e7pg8S1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
D [auth S]	V-set	e7pg8S2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
E [auth G]	C1-set_4	e7pg8G2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
E [auth G]	V-set	e7pg8G1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
F [auth D]	C1-set_4	e7pg8D1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
F [auth D]	V-set	e7pg8D2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
G [auth J]	C1-set_4	e7pg8J2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
G [auth J]	V-set	e7pg8J1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
I [auth B]	C1-set_1	e7pg8B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
I [auth B]	V-set_12	e7pg8B2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
O [auth U]	C1-set_1	e7pg8U1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
O [auth U]	V-set_12	e7pg8U2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
J [auth F]	C1-set_1	e7pg8F1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
J [auth F]	V-set_12	e7pg8F2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
K [auth I]	C1-set_1	e7pg8I2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
K [auth I]	V-set_12	e7pg8I1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
L	C1-set_1	e7pg8L1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
L	V-set_12	e7pg8L2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
M [auth N]	C1-set_1	e7pg8N2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
M [auth N]	V-set_12	e7pg8N1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
N [auth R]	C1-set_1	e7pg8R1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
N [auth R]	V-set_12	e7pg8R2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
P [auth X]	C1-set_1	e7pg8X1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
P [auth X]	V-set_12	e7pg8X2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
Q [auth C]	Ion_trans	e7pg8C1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans	ECOD (1.6)
R [auth E]	Ion_trans	e7pg8E1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans	ECOD (1.6)
S [auth H]	Ion_trans	e7pg8H1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans	ECOD (1.6)
V [auth Q]	Ion_trans	e7pg8Q1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans	ECOD (1.6)
T [auth K]	Ion_trans	e7pg8K1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans	ECOD (1.6)
U [auth O]	Ion_trans	e7pg8O1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans	ECOD (1.6)
W [auth T]	Ion_trans	e7pg8T1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans	ECOD (1.6)
X [auth W]	Ion_trans	e7pg8W1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans	ECOD (1.6)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
A [auth P], B [auth M], C [auth V], D [auth S], E [auth G], A [auth P], B [auth M], C [auth V], D [auth S], E [auth G], F [auth D], G [auth J], H [auth A]	Light Chain	IGKV1	Kappa	ion transport protein,voltage-gated sodium channel	SAbDab (2024-11-15)
I [auth B], J [auth F], K [auth I], L, M [auth N], I [auth B], J [auth F], K [auth I], L, M [auth N], N [auth R], O [auth U], P [auth X]	Heavy Chain	IGHV3	-	ion transport protein,voltage-gated sodium channel	SAbDab (2024-11-15)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
Q [auth C], R [auth E], S [auth H], T [auth K], U [auth O], Q [auth C], R [auth E], S [auth H], T [auth K], U [auth O], V [auth Q], W [auth T], X [auth W]	PF08016	Polycystin cation channel (PKD_channel)	Polycystin cation channel	-	Family
Q [auth C], R [auth E], S [auth H], T [auth K], U [auth O], Q [auth C], R [auth E], S [auth H], T [auth K], U [auth O], V [auth Q], W [auth T], X [auth W]	PF00520	Ion transport protein (Ion_trans)	Ion transport protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth P], B [auth M], C [auth V], D [auth S], E [auth G], A [auth P], B [auth M], C [auth V], D [auth S], E [auth G], F [auth D], G [auth J], H [auth A]	ANT05 H12 fab fragment, light chain	-	-	-
I [auth B], J [auth F], K [auth I], L, M [auth N], I [auth B], J [auth F], K [auth I], L, M [auth N], N [auth R], O [auth U], P [auth X]	ANT05 H12 fab fragment, heavy chain	-	-	-
Q [auth C], R [auth E], S [auth H], T [auth K], U [auth O], Q [auth C], R [auth E], S [auth H], T [auth K], U [auth O], V [auth Q], W [auth T], X [auth W]	Ion transport protein,Voltage-gated sodium channel	monoatomic cation transmembrane transporter activity voltage-gated sodium channel activity monoatomic ion channel activity sodium channel activity sodium ion transmembrane transporter activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity voltage-gated sodium channel activity monoatomic ion channel activity sodium channel activity sodium ion transmembrane transporter activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity cation binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding	-	protein-containing complex sodium channel complex voltage-gated sodium channel complex plasma membrane protein complex membrane plasma membrane membrane protein complex cation channel complex transporter complex cell periphery cellular anatomical structure transmembrane transporter complex monoatomic ion channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
Q [auth C], R [auth E], S [auth H], T [auth K], U [auth O], Q [auth C], R [auth E], S [auth H], T [auth K], U [auth O], V [auth Q], W [auth T], X [auth W]	IPR005821	Ion transport domain	Domain
Q [auth C], R [auth E], S [auth H], T [auth K], U [auth O], Q [auth C], R [auth E], S [auth H], T [auth K], U [auth O], V [auth Q], W [auth T], X [auth W]	IPR043203	Voltage-gated cation channel calcium and sodium	Family
Q [auth C], R [auth E], S [auth H], T [auth K], U [auth O], Q [auth C], R [auth E], S [auth H], T [auth K], U [auth O], V [auth Q], W [auth T], X [auth W]	IPR027359	Voltage-dependent channel domain superfamily	Homologous Superfamily
Q [auth C], R [auth E], S [auth H], T [auth K], U [auth O], Q [auth C], R [auth E], S [auth H], T [auth K], U [auth O], V [auth Q], W [auth T], X [auth W]	IPR005821	Ion transport domain	Domain
Q [auth C], R [auth E], S [auth H], T [auth K], U [auth O], Q [auth C], R [auth E], S [auth H], T [auth K], U [auth O], V [auth Q], W [auth T], X [auth W]	IPR043203	Voltage-gated cation channel calcium and sodium	Family
Q [auth C], R [auth E], S [auth H], T [auth K], U [auth O], Q [auth C], R [auth E], S [auth H], T [auth K], U [auth O], V [auth Q], W [auth T], X [auth W]	IPR027359	Voltage-dependent channel domain superfamily	Homologous Superfamily

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
Q [auth C], R [auth E], S [auth H], T [auth K], U [auth O] Q [auth C], R [auth E], S [auth H], T [auth K], U [auth O], V [auth Q], W [auth T], X [auth W]	PDBTM	Annotated as membrane protein by PDBTM