7POU

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	fragilysinNterm	e7pouA2	A: a+b two layers	X: Fragilysin-3 prodomain-like	H: Fragilysin-3 prodomain (From Topology)	T: Fragilysin-3 prodomain	F: fragilysinNterm	ECOD (1.6)
A	Reprolysin	e7pouA1	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Reprolysin	ECOD (1.6)
B	fragilysinNterm	e7pouB2	A: a+b two layers	X: Fragilysin-3 prodomain-like	H: Fragilysin-3 prodomain (From Topology)	T: Fragilysin-3 prodomain	F: fragilysinNterm	ECOD (1.6)
B	Reprolysin	e7pouB1	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Reprolysin	ECOD (1.6)

Chains	Accession	Name	Description	Comments	Source
A, B	PF16376	N-terminal domain of fragilysin (fragilysinNterm)	N-terminal domain of fragilysin	N-terminal domain of fragilysin, an extracellular metalloprotease toxin, which is primary virulence factor of B. fragilis, an oportunistic pathogen of human gut. The N-terminal domain of fragilysin inhibits fragilysin and is cleaved ...	N-terminal domain of fragilysin, an extracellular metalloprotease toxin, which is primary virulence factor of B. fragilis, an oportunistic pathogen of human gut. The N-terminal domain of fragilysin inhibits fragilysin and is cleaved in a mature, virulent form.	Domain
A, B	PF13583	Metallo-peptidase family M12B Reprolysin-like (Reprolysin_4)	Metallo-peptidase family M12B Reprolysin-like	This zinc-binding metallo-peptidase has the characteristic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.	Domain

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	BFT-3	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding	proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	-

Chains	Accession	Name	Type
A, B	IPR038176	Fragilysin, N-terminal domain superfamily	Homologous Superfamily
A, B	IPR006026	Peptidase, metallopeptidase	Domain
A, B	IPR024079	Metallopeptidase, catalytic domain superfamily	Homologous Superfamily
A, B	IPR032273	Fragilysin, N-terminal	Domain
A, B	IPR001843	Fragilysin	Family