7QQ6

GCN2 (EIF2ALPHA KINASE 4, E2AK4) IN COMPLEX WITH COMPOUND 1 (dovitinib)

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Pkinase_Tyr	e7qq6A1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
B	Pkinase_Tyr	e7qq6B1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
D	Pkinase_Tyr	e7qq6D1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
C	Pkinase_Tyr	e7qq6C1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	eIF-2-alpha kinase GCN2	protein serine/threonine kinase activity eukaryotic translation initiation factor 2alpha kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups RNA binding binding organic cyclic compound binding tRNA binding nucleic acid binding protein serine/threonine kinase activity eukaryotic translation initiation factor 2alpha kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups RNA binding binding organic cyclic compound binding tRNA binding nucleic acid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine kinase activity	multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process negative regulation of cell differentiation system development multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process negative regulation of cell differentiation system development developmental process regulation of biological process negative regulation of developmental process biological regulation nervous system development generation of neurons cellular process negative regulation of neuron differentiation regulation of neuron differentiation cellular response to stimulus response to stimulus signaling integrated stress response signaling intracellular signal transduction cell communication cellular response to stress response to stress intracellular signaling cassette signal transduction GCN2-mediated signaling behavior system process learning learning or memory nervous system process cognition immune response immune system process adaptive immune response regulation of adaptive immune response positive regulation of biological process positive regulation of response to stimulus regulation of response to stimulus positive regulation of immune response regulation of immune response regulation of immune system process positive regulation of adaptive immune response positive regulation of immune system process cellular biosynthetic process negative regulation of cellular metabolic process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation translational initiation protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of translational initiation in response to stress regulation of biosynthetic process regulation of translational initiation cellular metabolic process regulation of protein metabolic process negative regulation of metabolic process negative regulation of translational initiation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process protein phosphorylation protein autophosphorylation phosphorylation macromolecule modification phosphate-containing compound metabolic process protein modification process phosphorus metabolic process negative regulation of DNA-binding transcription factor activity RNA metabolic process negative regulation of CREB transcription factor activity nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of molecular function nucleobase-containing compound biosynthetic process nucleic acid metabolic process regulation of molecular function regulation of DNA-binding transcription factor activity regulation of DNA-templated transcription viral gene expression viral process viral translation regulation of translational initiation by eIF2 alpha phosphorylation regulation of translation in response to stress regulation of translational initiation in response to stress regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus regulation of defense response to virus defense response to virus defense response to other organism regulation of response to stress positive regulation of defense response to virus by host regulation of defense response to virus by host response to external biotic stimulus response to virus cell activation lymphocyte activation cell activation involved in immune response leukocyte activation immune effector process T cell activation involved in immune response T cell activation leukocyte activation involved in immune response lymphocyte activation involved in immune response regulation of behavior feeding behavior regulation of feeding behavior regulation of multicellular organismal process response to nutrient levels cellular response to amino acid starvation cellular response to starvation cellular response to nutrient levels response to amino acid starvation response to starvation DNA damage checkpoint signaling regulation of cell cycle phase transition negative regulation of cell cycle cell cycle phase transition negative regulation of cell cycle phase transition cell cycle regulation of cell cycle cell cycle process regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling DNA damage response signal transduction in response to DNA damage negative regulation by host of viral genome replication modulation by host of symbiont process viral life cycle negative regulation by host of viral process modulation by host of viral genome replication biological process involved in symbiotic interaction modulation by host of viral process viral genome replication biological process involved in interaction with symbiont positive regulation of cell communication modulation of chemical synaptic transmission long-term synaptic potentiation synaptic signaling positive regulation of long-term synaptic potentiation regulation of biological quality positive regulation of cellular process regulation of synaptic plasticity trans-synaptic signaling regulation of signaling cell-cell signaling positive regulation of synaptic transmission chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of long-term synaptic potentiation regulation of cell communication positive regulation of signaling developmental growth cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell growth cell morphogenesis cellular component organization cell projection morphogenesis neuron projection morphogenesis cellular component organization or biogenesis neuron projection extension plasma membrane bounded cell projection organization developmental cell growth growth developmental growth involved in morphogenesis anatomical structure morphogenesis neuron development long-term memory memory response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to light stimulus response to radiation response to abiotic stimulus cellular response to abiotic stimulus cellular response to UV response to endoplasmic reticulum stress regulation of translation initiation in response to endoplasmic reticulum stress regulation of translation in response to endoplasmic reticulum stress eiF2alpha phosphorylation in response to endoplasmic reticulum stress cellular response to cold response to cold response to temperature stimulus negative regulation of translation in response to stress regulation of cytoplasmic translational initiation in response to stress negative regulation of cytoplasmic translational initiation in response to stress regulation of cytoplasmic translation negative regulation of cytoplasmic translational initiation regulation of cytoplasmic translation in response to stress regulation of cytoplasmic translational initiation cytoplasmic translation cytoplasmic translational initiation positive regulation of macromolecule biosynthetic process positive regulation of translational initiation in response to stress positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of translation in response to stress positive regulation of translational initiation positive regulation of protein metabolic process positive regulation of translation positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of translational initiation in response to starvation positive regulation of gene expression regulation of translational initiation in response to starvation positive regulation of cellular biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol intracellular organelle cytosolic ribosome organelle intracellular non-membrane-bounded organelle ribosome non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR041715	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain	Domain
A, B, C, D	IPR000719	Protein kinase domain	Domain
A, B, C, D	IPR006575	RWD domain	Domain
A, B, C, D	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B, C, D	IPR045864	Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)	Homologous Superfamily
A, B, C, D	IPR016135	Ubiquitin-conjugating enzyme/RWD-like	Homologous Superfamily
A, B, C, D	IPR050339	Cell Cycle and Stress Response Kinase	Family
A, B, C, D	IPR036621	Anticodon-binding domain superfamily	Homologous Superfamily
A, B, C, D	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B, C, D	IPR016255	eIF-2-alpha kinase Gcn2	Family
A, B, C, D	IPR024435	Histidyl tRNA synthetase-related domain	Domain
A, B, C, D	IPR008271	Serine/threonine-protein kinase, active site	Active Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q9P2K8	pulmonary venoocclusive disease pulmonary hypertension pulmonary venoocclusive disease 2 myopathy disease of pilosebaceous unit ovarian cancer subependymal giant cell astrocytoma Amino Acid Metabolism, Inborn Errors B-cell chronic lymphocytic leukemia idiopathic pulmonary arterial hypertension inherited amino acid metabolic disorder primary pulmonary hypertension thrombocytopenia due to immune destruction Crohn ileitis endometrial carcinoma pulmonary venoocclusive disease pulmonary hypertension pulmonary venoocclusive disease 2 myopathy disease of pilosebaceous unit ovarian cancer subependymal giant cell astrocytoma Amino Acid Metabolism, Inborn Errors B-cell chronic lymphocytic leukemia idiopathic pulmonary arterial hypertension inherited amino acid metabolic disorder primary pulmonary hypertension thrombocytopenia due to immune destruction Crohn ileitis endometrial carcinoma immune system disease muscle tissue disease osteosarcoma pulmonary arterial hypertension pulmonary venoocclusive disease 1 rheumatoid arthritis atypical teratoid rhabdoid tumor cystic fibrosis Ewing sarcoma glioblastoma muscular disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.