7SZT

Crystal structure of Gdx-Clo from Small Multidrug Resistance family of transporters in low pH (protonated state)

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E	fn3	e7sztE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: fn3	ECOD (1.6)
F	fn3	e7sztF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: fn3	ECOD (1.6)
G [auth H]	fn3	e7sztH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: fn3	ECOD (1.6)
H [auth G]	fn3	e7sztG1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: fn3	ECOD (1.6)
A	Multi_Drug_Res	e7sztA1	A: alpha bundles	X: Drug/Metabolite transporter (From Topology)	H: Drug/Metabolite transporter (From Topology)	T: Drug/Metabolite transporter	F: Multi_Drug_Res	ECOD (1.6)
B	Multi_Drug_Res	e7sztB1	A: alpha bundles	X: Drug/Metabolite transporter (From Topology)	H: Drug/Metabolite transporter (From Topology)	T: Drug/Metabolite transporter	F: Multi_Drug_Res	ECOD (1.6)
C	Multi_Drug_Res	e7sztC1	A: alpha bundles	X: Drug/Metabolite transporter (From Topology)	H: Drug/Metabolite transporter (From Topology)	T: Drug/Metabolite transporter	F: Multi_Drug_Res	ECOD (1.6)
D	Multi_Drug_Res	e7sztD1	A: alpha bundles	X: Drug/Metabolite transporter (From Topology)	H: Drug/Metabolite transporter (From Topology)	T: Drug/Metabolite transporter	F: Multi_Drug_Res	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00893	Small Multidrug Resistance protein (Multi_Drug_Res)	Small Multidrug Resistance protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
E, F, G [auth H], H [auth G]	L10 monobody	-	-	-
A, B, C, D	Multidrug resistance protein, SMR family	transporter activity transmembrane transporter activity	-	cell periphery cellular anatomical structure plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR000390	Small drug/metabolite transporter protein family	Family
A, B, C, D	IPR045324	Small multidrug resistance protein	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D	OPM	Transmembrane	Alpha-helical polytopic	Drug/Metabolite Transporter (DMT)	Small multidrug resistance family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Multi-Drug Efflux Transporters	EmrE-D3 mutant bacterial multi-drug efflux transporter in complex with monobody L10 in low pH (protonated state)

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.