Annotations: 7UDC

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Sec1/munc18-like	8037630	3001920	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	t-snare proteins	8037582	3000366	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	SNARE fusion complex	8079907	3001549	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Sec1_3rd	e7udcA3	A: alpha complex topology	X: alpha-helical domain in sec1/munc18-like (SM) proteins (From Topology)	H: alpha-helical domain in sec1/munc18-like (SM) proteins (From Topology)	T: alpha-helical domain in sec1/munc18-like (SM) proteins	F: Sec1_3rd	ECOD (1.6)
A	Sec1_1st_1	e7udcA1	A: a/b three-layered sandwiches	X: Rossmann-like domains in Sec1/munc18-like proteins (From Topology)	H: Rossmann-like domains in Sec1/munc18-like proteins (From Topology)	T: Rossmann-like domains in Sec1/munc18-like proteins	F: Sec1_1st_1	ECOD (1.6)
A	Sec1_2nd	e7udcA2	A: a/b three-layered sandwiches	X: Rossmann-like domains in Sec1/munc18-like proteins (From Topology)	H: Rossmann-like domains in Sec1/munc18-like proteins (From Topology)	T: Rossmann-like domains in Sec1/munc18-like proteins	F: Sec1_2nd	ECOD (1.6)
C	Synaptobrevin	e7udcC1	A: extended segments	X: Synaptobrevin (From Topology)	H: Synaptobrevin (From Topology)	T: Synaptobrevin	F: Synaptobrevin	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00995	Sec1 family (Sec1)	Sec1 family	-	Family
B	PF05739	SNARE domain (SNARE)	SNARE domain	-	Family
B	PF00804	Syntaxin (Syntaxin)	Syntaxin	Syntaxins are the prototype family of SNARE proteins. They usually consist of three main regions - a C-terminal transmembrane region, a central SNARE domain which is characteristic of and conserved in all syntaxins (Pfam:PF05739), and an N-terminal d ...	Syntaxins are the prototype family of SNARE proteins. They usually consist of three main regions - a C-terminal transmembrane region, a central SNARE domain which is characteristic of and conserved in all syntaxins (Pfam:PF05739), and an N-terminal domain that is featured in this entry. This domain varies between syntaxin isoforms; in syntaxin 1A (Swiss:O35526) it is found as three alpha-helices with a left-handed twist. It may fold back on the SNARE domain to allow the molecule to adopt a 'closed' configuration that prevents formation of the core fusion complex - it thus has an auto-inhibitory role. The function of syntaxins is determined by their localisation. They are involved in neuronal exocytosis, ER-Golgi transport and Golgi-endosome transport, for example. They also interact with other proteins as well as those involved in SNARE complexes. These include vesicle coat proteins, Rab GTPases, and tethering factors [6].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Syntaxin-binding protein 1	protein binding binding SNARE binding syntaxin binding molecular adaptor activity identical protein binding phospholipase binding enzyme binding protein domain specific binding syntaxin-1 binding kinase binding protein kinase binding	regulation of protein stability biological regulation regulation of biological quality protein stabilization regulation of localization regulation of cellular component organization regulation of cellular process transport membrane fusion organelle membrane fusion regulation of vesicle fusion vesicle-mediated transport vesicle organization cellular component organization regulation of protein stability biological regulation regulation of biological quality protein stabilization regulation of localization regulation of cellular component organization regulation of cellular process transport membrane fusion organelle membrane fusion regulation of vesicle fusion vesicle-mediated transport vesicle organization cellular component organization localization cellular component organization or biogenesis membrane organization regulation of biological process regulation of transport regulation of vesicle-mediated transport establishment of localization regulation of organelle organization organelle fusion organelle organization cellular process vesicle fusion protein-containing complex organization cellular component biogenesis cellular component assembly protein-containing complex assembly SNARE complex assembly establishment of organelle localization multicellular organismal process regulation of immune effector process regulated exocytosis regulation of myeloid leukocyte mediated immunity response to stimulus cell activation involved in immune response leukocyte degranulation myeloid leukocyte activation myeloid leukocyte mediated immunity positive regulation of leukocyte degranulation positive regulation of regulated secretory pathway establishment of localization in cell leukocyte mediated immunity regulation of immune system process positive regulation of mast cell degranulation positive regulation of immune system process immune response vacuolar localization mast cell degranulation immune effector process regulation of secretion regulation of leukocyte mediated immunity exocytosis lysosome localization cellular localization positive regulation of biological process positive regulation of secretion by cell positive regulation of exocytosis regulation of mast cell degranulation leukocyte activation regulation of regulated secretory pathway secretion by cell regulation of secretion by cell positive regulation of secretion organelle localization leukocyte activation involved in immune response mast cell activation positive regulation of immune effector process regulation of leukocyte degranulation positive regulation of cellular process mast cell mediated immunity secretion cell activation export from cell myeloid cell activation involved in immune response mast cell activation involved in immune response positive regulation of transport immune system process regulation of exocytosis regulation of body fluid levels wound healing homotypic cell-cell adhesion hemostasis platelet aggregation blood coagulation cell adhesion cell-cell adhesion response to stress coagulation response to wounding platelet activation protein localization protein localization to cell periphery protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane negative regulation of cellular component organization negative regulation of biological process regulation of cellular component biogenesis negative regulation of protein-containing complex assembly regulation of protein-containing complex assembly negative regulation of cellular process trans-synaptic signaling signaling cell-cell signaling chemical synaptic transmission cell communication synaptic signaling anterograde trans-synaptic signaling neuromuscular synaptic transmission regulation of calcium ion-dependent exocytosis calcium-ion regulated exocytosis positive regulation of calcium ion-dependent exocytosis synaptic vesicle priming regulation of synaptic vesicle priming synaptic vesicle cycle synaptic vesicle exocytosis vesicle-mediated transport in synapse signal release neurotransmitter secretion neurotransmitter transport signal release from synapse exocytic process negative regulation of vesicle fusion negative regulation of transport negative regulation of SNARE complex assembly regulation of SNARE complex assembly negative regulation of organelle organization dense core granule localization presynaptic dense core vesicle exocytosis secretory granule localization vesicle localization calcium ion-regulated exocytosis of neurotransmitter establishment of vesicle localization neuronal dense core vesicle exocytosis dense core granule exocytosis negative regulation of synaptic transmission, GABAergic negative regulation of signaling modulation of chemical synaptic transmission negative regulation of synaptic transmission negative regulation of cell communication regulation of signaling synaptic transmission, GABAergic regulation of trans-synaptic signaling regulation of cell communication regulation of synaptic transmission, GABAergic sexual reproduction reproductive process fertilization acrosome reaction single fertilization acrosomal vesicle exocytosis regulation of acrosomal vesicle exocytosis membrane docking organelle localization by membrane tethering positive regulation of vesicle docking vesicle docking regulation of vesicle docking vesicle docking involved in exocytosis neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death regulation of neuron apoptotic process establishment of protein localization nitrogen compound transport intracellular transport protein transport intracellular protein transport biological process involved in interspecies interaction between organisms response to other organism defense response response to type II interferon response to cytokine defense response to symbiont response to external stimulus cellular response to type II interferon response to biotic stimulus response to peptide response to chemical defense response to other organism innate immune response cellular response to cytokine stimulus response to external biotic stimulus axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development system development developmental process plasma membrane bounded cell projection organization axon target recognition nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development platelet degranulation regulation of synaptic plasticity long-term synaptic depression developmental process involved in reproduction synaptic vesicle maturation developmental maturation positive regulation of cell communication synaptic transmission, glutamatergic regulation of glutamate secretion positive regulation of neurotransmitter secretion positive regulation of amine transport regulation of amino acid transport glutamate secretion positive regulation of neurotransmitter transport carboxylic acid transport positive regulation of synaptic transmission organic acid transport acidic amino acid transport glutamate secretion, neurotransmission positive regulation of glutamate secretion, neurotransmission positive regulation of amino acid transport dicarboxylic acid transport regulation of synaptic transmission, glutamatergic L-amino acid transport L-glutamate import organic anion transport regulation of neurotransmitter transport positive regulation of glutamate secretion positive regulation of synaptic transmission, glutamatergic positive regulation of organic acid transport amino acid transport amine transport regulation of glutamate secretion, neurotransmission regulation of neurotransmitter secretion regulation of organic acid transport regulation of amine transport positive regulation of signaling response to lipid response to estradiol response to oxygen-containing compound response to organic cyclic compound	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol parallel fiber to Purkinje cell synapse synapse cell junction excitatory synapse membrane-bounded organelle intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol parallel fiber to Purkinje cell synapse synapse cell junction excitatory synapse membrane-bounded organelle intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle vesicle cell cortex cytoplasmic region presynaptic active zone cytoplasmic component cell periphery presynapse cell cortex region presynaptic active zone glutamatergic synapse perinuclear region of cytoplasm axon cell projection neuron projection plasma membrane bounded cell projection postsynapse axon terminus distal axon terminal bouton neuron projection terminus cytosolic region presynaptic cytosol phagocytic vesicle endocytic vesicle plasma membrane membrane nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-containing complex presynaptic active zone membrane presynaptic membrane synaptic membrane plasma membrane region platelet alpha granule extrinsic component of plasma membrane extrinsic component of synaptic membrane extrinsic component of presynaptic membrane extrinsic component of membrane
B	Syntaxin-1A	molecular function inhibitor activity chloride channel inhibitor activity channel regulator activity transporter inhibitor activity ion channel regulator activity ion channel inhibitor activity molecular function regulator activity transporter regulator activity channel inhibitor activity chloride channel regulator activity SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity protein-containing complex binding molecular function inhibitor activity chloride channel inhibitor activity channel regulator activity transporter inhibitor activity ion channel regulator activity ion channel inhibitor activity molecular function regulator activity transporter regulator activity channel inhibitor activity chloride channel regulator activity SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity protein-containing complex binding binding calcium channel inhibitor activity calcium channel regulator activity identical protein binding protein binding myosin heavy chain binding cytoskeletal protein binding myosin head/neck binding myosin binding ATP-dependent protein binding kinase binding enzyme binding transmembrane transporter binding SNARE binding calcium-dependent protein binding	localization transport neurotransmitter transport establishment of localization cellular response to stimulus multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process response to stimulus signaling modulation of chemical synaptic transmission regulation of system process regulation of signal transduction localization transport neurotransmitter transport establishment of localization cellular response to stimulus multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process response to stimulus signaling modulation of chemical synaptic transmission regulation of system process regulation of signal transduction chemical synaptic transmission, postsynaptic cell communication synaptic signaling modulation of excitatory postsynaptic potential regulation of multicellular organismal process signal transduction regulation of biological quality trans-synaptic signaling regulation of biological process regulation of signaling cell surface receptor signaling pathway nervous system process biological regulation cell-cell signaling chemical synaptic transmission regulation of nervous system process regulation of trans-synaptic signaling regulation of response to stimulus anterograde trans-synaptic signaling regulation of cell communication cellular process excitatory postsynaptic potential regulation of membrane potential positive regulation of cell communication positive regulation of signal transduction positive regulation of excitatory postsynaptic potential positive regulation of biological process positive regulation of response to stimulus positive regulation of cellular process positive regulation of signaling regulated exocytosis secretion export from cell vesicle-mediated transport secretion by cell exocytosis calcium-ion regulated exocytosis membrane organization protein-containing complex organization membrane fusion organelle membrane fusion cellular component organization cellular component biogenesis vesicle organization organelle fusion organelle organization cellular component assembly protein-containing complex assembly SNARE complex assembly cellular component organization or biogenesis vesicle fusion peptidyl-lysine modification primary metabolic process protein sumoylation macromolecule modification peptidyl-amino acid modification metabolic process protein metabolic process macromolecule metabolic process protein modification process post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal monoamine transport regulation of localization nitrogen compound transport regulation of catecholamine secretion organic hydroxy compound transport positive regulation of secretion by cell positive regulation of amine transport regulation of secretion by cell catecholamine transport positive regulation of secretion regulation of transport positive regulation of catecholamine secretion regulation of secretion catecholamine secretion amine transport positive regulation of transport regulation of amine transport regulation of calcium ion-dependent exocytosis positive regulation of exocytosis regulation of regulated secretory pathway positive regulation of regulated secretory pathway positive regulation of calcium ion-dependent exocytosis regulation of vesicle-mediated transport regulation of exocytosis protein localization cellular localization cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane regulation of hormone levels hormone secretion signal release hormone transport regulation of cellular component organization synaptic vesicle priming regulation of synaptic vesicle priming synaptic vesicle cycle synaptic vesicle exocytosis vesicle-mediated transport in synapse regulation of protein-containing complex assembly establishment of localization in cell neurotransmitter secretion regulation of cellular component biogenesis signal release from synapse exocytic process response to abiotic stimulus response to gravity establishment of protein localization protein localization to extracellular region peptide secretion amide transport establishment of protein localization to extracellular region protein secretion peptide transport protein transport peptide hormone secretion insulin secretion organelle localization by membrane tethering organelle localization vesicle docking membrane docking vesicle docking involved in exocytosis synaptic vesicle docking synaptic vesicle endocytosis import into cell presynaptic endocytosis synaptic vesicle recycling endocytosis intracellular transport intracellular protein transport positive regulation of neurotransmitter secretion positive regulation of neurotransmitter transport regulation of neurotransmitter transport positive regulation of synaptic transmission regulation of neurotransmitter secretion endomembrane system organization vesicle fusion to plasma membrane synaptic vesicle fusion to presynaptic active zone membrane synaptic vesicle membrane organization norepinephrine transport positive regulation of norepinephrine secretion organic cation transport norepinephrine secretion regulation of norepinephrine secretion	postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse cellular anatomical structure neuron to neuron synapse organelle cell junction postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse cellular anatomical structure neuron to neuron synapse organelle cell junction postsynaptic membrane asymmetric synapse plasma membrane region membrane-bounded organelle intracellular anatomical structure nuclear membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope nuclear envelope organelle membrane cytoskeleton membraneless organelle intracellular membraneless organelle actin cytoskeleton actomyosin presynapse presynaptic membrane intracellular vesicle cytoplasmic vesicle secretory granule secretory vesicle cytoplasm vesicle glutamatergic synapse cell projection neuron projection plasma membrane bounded cell projection SNARE complex protein-containing complex synaptobrevin 2-SNAP-25-syntaxin-1a complex membrane protein complex synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex transport vesicle membrane bounding membrane of organelle vesicle membrane synaptic vesicle synaptic vesicle membrane transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane exocytic vesicle axon synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex acrosomal vesicle presynaptic active zone membrane presynaptic active zone Schaffer collateral - CA1 synapse
C	Synaptobrevin-2	protein binding binding SNARE binding syntaxin binding phospholipid binding lipid binding SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity calmodulin binding syntaxin-1 binding calcium-dependent protein binding	protein localization Golgi to plasma membrane transport establishment of protein localization cellular localization nitrogen compound transport post-Golgi vesicle-mediated transport transport establishment of protein localization to plasma membrane Golgi to plasma membrane protein transport vesicle-mediated transport localization cellular macromolecule localization protein localization to cell periphery establishment of protein localization to membrane protein localization Golgi to plasma membrane transport establishment of protein localization cellular localization nitrogen compound transport post-Golgi vesicle-mediated transport transport establishment of protein localization to plasma membrane Golgi to plasma membrane protein transport vesicle-mediated transport localization cellular macromolecule localization protein localization to cell periphery establishment of protein localization to membrane protein localization to plasma membrane localization within membrane protein localization to membrane establishment of localization vesicle-mediated transport to the plasma membrane protein transport macromolecule localization cellular process Golgi vesicle transport regulated exocytosis secretion export from cell secretion by cell exocytosis calcium-ion regulated exocytosis membrane organization protein-containing complex organization membrane fusion organelle membrane fusion cellular component organization cellular component biogenesis vesicle organization organelle fusion organelle organization cellular component assembly protein-containing complex assembly SNARE complex assembly cellular component organization or biogenesis vesicle fusion multicellular organismal process response to stimulus eosinophil activation cell activation involved in immune response leukocyte degranulation myeloid leukocyte mediated immunity myeloid leukocyte activation leukocyte activation establishment of localization in cell leukocyte activation involved in immune response eosinophil degranulation leukocyte mediated immunity eosinophil activation involved in immune response immune response cell activation myeloid cell activation involved in immune response immune effector process immune system process eosinophil mediated immunity granulocyte activation signaling synaptic vesicle cycle synaptic vesicle exocytosis cell communication vesicle-mediated transport in synapse synaptic signaling signal release trans-synaptic signaling regulation of biological process neurotransmitter secretion biological regulation cell-cell signaling neurotransmitter transport chemical synaptic transmission signal release from synapse anterograde trans-synaptic signaling regulation of localization regulation of cellular process regulation of protein localization positive regulation of biological process positive regulation of establishment of protein localization positive regulation of protein transport positive regulation of intracellular transport positive regulation of cellular process regulation of intracellular transport regulation of transport regulation of establishment of protein localization intracellular transport regulation of protein transport positive regulation of transport regulation of cellular localization positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport synaptic vesicle endocytosis import into cell presynaptic endocytosis synaptic vesicle recycling endocytosis regulation of potassium ion transport monoatomic ion transmembrane transport potassium ion transmembrane transport regulation of transmembrane transporter activity regulation of delayed rectifier potassium channel activity regulation of monoatomic ion transmembrane transport metal ion transport regulation of transporter activity monoatomic cation transmembrane transport monoatomic ion transport monoatomic cation transport regulation of metal ion transport regulation of potassium ion transmembrane transporter activity regulation of monoatomic ion transmembrane transporter activity regulation of monoatomic ion transport inorganic ion transmembrane transport regulation of potassium ion transmembrane transport regulation of cation channel activity inorganic cation transmembrane transport transmembrane transport regulation of molecular function regulation of transmembrane transport potassium ion transport regulation of monoatomic cation transmembrane transport response to hexose response to monosaccharide response to carbohydrate response to glucose response to chemical response to oxygen-containing compound regulation of vesicle-mediated transport regulation of secretion regulation of secretion by cell regulation of exocytosis cellular response to nitrogen compound cellular response to stimulus response to endogenous stimulus response to peptide hormone cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to insulin cellular response to insulin stimulus cellular response to hormone stimulus positive regulation of cell communication modulation of chemical synaptic transmission long-term synaptic potentiation regulation of biological quality regulation of synaptic plasticity regulation of signaling positive regulation of synaptic transmission regulation of trans-synaptic signaling regulation of cell communication positive regulation of signaling	cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle vesicle endocytic vesicle cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin-coated endocytic vesicle membrane intracellular membrane-bounded organelle clathrin-coated endocytic vesicle cytoplasmic vesicle membrane coated vesicle membrane organelle cytoplasm organelle membrane clathrin-sculpted glutamate transport vesicle clathrin-sculpted vesicle transport vesicle membrane endomembrane system clathrin-sculpted glutamate transport vesicle membrane transport vesicle cytosol secretory granule secretory vesicle clathrin-sculpted gamma-aminobutyric acid transport vesicle clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane cell projection neuron projection plasma membrane bounded cell projection Golgi apparatus subcompartment Golgi apparatus organelle subcompartment trans-Golgi network SNARE complex protein-containing complex synaptobrevin 2-SNAP-25-syntaxin-1a complex membrane protein complex synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex perinuclear region of cytoplasm zymogen granule zymogen granule membrane secretory granule membrane synapse presynapse synaptic vesicle synaptic vesicle membrane cell junction exocytic vesicle membrane exocytic vesicle synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex clathrin-sculpted monoamine transport vesicle clathrin-sculpted monoamine transport vesicle membrane cell periphery plasma membrane neuron projection terminus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR043154	Sec1-like, domain 1	Homologous Superfamily
A	IPR043127	Sec1-like, domain 3a	Homologous Superfamily
A	IPR001619	Sec1-like protein	Family
A	IPR036045	Sec1-like superfamily	Homologous Superfamily
A	IPR027482	Sec1-like, domain 2	Homologous Superfamily
B	IPR000727	Target SNARE coiled-coil homology domain	Domain
B	IPR006012	Syntaxin/epimorphin, conserved site	Conserved Site
B	IPR010989	SNARE	Homologous Superfamily
B	IPR006011	Syntaxin, N-terminal domain	Domain
B	IPR045242	Syntaxin	Family
C	IPR016444	Synaptobrevin/Vesicle-associated membrane protein	Family
C	IPR042855	v-SNARE, coiled-coil homology domain	Domain
C	IPR001388	Synaptobrevin-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C	Pharos: P63027	astrocytic tumor endogenous depression lung cancer malignant glioma osteosarcoma rheumatoid arthritis tetanus atypical teratoid rhabdoid tumor Gaucher disease major depressive disorder medulloblastoma pilocytic astrocytoma schizophrenia Unipolar Depression botulism astrocytic tumor endogenous depression lung cancer malignant glioma osteosarcoma rheumatoid arthritis tetanus atypical teratoid rhabdoid tumor Gaucher disease major depressive disorder medulloblastoma pilocytic astrocytoma schizophrenia Unipolar Depression botulism glioblastoma malignant ependymoma oligodendroglioma psoriasis subependymal giant cell astrocytoma

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	SNARE Protein Family	synaptobrevin-Munc18-1-syntaxin-1 complex class 2

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.