Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyTrypsin-like serine proteases 8092431 3000114 SCOP2B (2022-06-29)
B [auth D]SCOP2B SuperfamilyTrypsin-like serine proteases 8092431 3000114 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyTrypsin-like serine proteases 8092431 3000114 SCOP2B (2022-06-29)
D [auth B]SCOP2B SuperfamilyTrypsin-like serine proteases 8092431 3000114 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APeptidase_C30_Ne7mb4A1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: FMN-binding split barrelF: Peptidase_C30_NECOD (1.6)
APeptidase_C30_Ce7mb4A2 A: alpha arraysX: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain (From Topology)H: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain (From Topology)T: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainF: Peptidase_C30_CECOD (1.6)
B [auth D]Peptidase_C30_Ne7mb4D2 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: FMN-binding split barrelF: Peptidase_C30_NECOD (1.6)
B [auth D]Peptidase_C30_Ce7mb4D1 A: alpha arraysX: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain (From Topology)H: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain (From Topology)T: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainF: Peptidase_C30_CECOD (1.6)
CPeptidase_C30_Ne7mb4C2 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: FMN-binding split barrelF: Peptidase_C30_NECOD (1.6)
CPeptidase_C30_Ce7mb4C1 A: alpha arraysX: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain (From Topology)H: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain (From Topology)T: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainF: Peptidase_C30_CECOD (1.6)
D [auth B]Peptidase_C30_Ne7mb4B1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: FMN-binding split barrelF: Peptidase_C30_NECOD (1.6)
D [auth B]Peptidase_C30_Ce7mb4B2 A: alpha arraysX: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain (From Topology)H: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain (From Topology)T: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainF: Peptidase_C30_CECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A,
B [auth D],
C,
D [auth B]
PF05409Coronavirus endopeptidase C30 (Peptidase_C30)Coronavirus endopeptidase C30- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A,
B [auth D],
C,
D [auth B]
3C-like proteinase
E,
F [auth H],
G,
H [auth F]
THR-SER-ALA-VAL-LEU-GLN

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A,
B [auth D],
C,
D [auth B]
IPR022733DPUP/SUD, C-terminal, betacoronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR042515Non-structural protein NSP15, N-terminal domain superfamily, coronavirusHomologous Superfamily
A,
B [auth D],
C,
D [auth B]
IPR043174Non-structural protein NSP15, middle domain superfamilyHomologous Superfamily
A,
B [auth D],
C,
D [auth B]
IPR044315Nonstructural protein 14, betacoronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR038123Non-structural protein NSP4, C-terminal superfamily, coronavirusHomologous Superfamily
A,
B [auth D],
C,
D [auth B]
IPR042570Non-structural protein NSP3, nucleic acid-binding domain superfamily, betacoronavirusHomologous Superfamily
A,
B [auth D],
C,
D [auth B]
IPR043178Papain-like protease, thumb domain superfamily, coronavirusHomologous Superfamily
A,
B [auth D],
C,
D [auth B]
IPR046441RNA-dependent RNA polymerase, coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR044863Nidovirus RdRp-associated nucleotidyl transferase (NiRAN) domainDomain
A,
B [auth D],
C,
D [auth B]
IPR044343Nonstructural protein 13, 1B domain, coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR038166Polyprotein cleavage domain PL2pro superfamily, betacoronavirusHomologous Superfamily
A,
B [auth D],
C,
D [auth B]
IPR037227Endoribonuclease EndoU-likeHomologous Superfamily
A,
B [auth D],
C,
D [auth B]
IPR027352Nonstructural protein 13, zinc-binding domain, coronavirus-likeDomain
A,
B [auth D],
C,
D [auth B]
IPR009003Peptidase S1, PA clanHomologous Superfamily
A,
B [auth D],
C,
D [auth B]
IPR013016Peptidase C16, coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR009466Non-structural protein 14, coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR044357NSP3, first ubiquitin-like (Ubl) domain, coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR046436Nidovirus 3'-5' exoribonuclease domainDomain
A,
B [auth D],
C,
D [auth B]
IPR047570NSP12, interface domain, coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR018995RNA synthesis protein NSP10, coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR043615Nonstructural protein 2, N-terminal domain, coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR050534Coronaviruses polyprotein 1abFamily
A,
B [auth D],
C,
D [auth B]
IPR043177Papain-like protease, N-terminal domain superfamily, coronavirusHomologous Superfamily
A,
B [auth D],
C,
D [auth B]
IPR043606Coronavirus replicase NSP15, N-terminal oligomerizationDomain
A,
B [auth D],
C,
D [auth B]
IPR044330Nonstructural protein 15, N-terminal domain, alpha/beta-coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR041679DNA2/NAM7 helicase-like, C-terminalDomain
A,
B [auth D],
C,
D [auth B]
IPR024375Non-structural protein NSP3, SUD-M domain, betacoronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR014828Non-structural protein NSP7, coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR043503Papain-like viral protease, palm and finger domains, coronavirusHomologous Superfamily
A,
B [auth D],
C,
D [auth B]
IPR014829Non-structural protein NSP8, coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR036499Non-structural protein NSP9 superfamily, coronavirusHomologous Superfamily
A,
B [auth D],
C,
D [auth B]
IPR029063S-adenosyl-L-methionine-dependent methyltransferase superfamilyHomologous Superfamily
A,
B [auth D],
C,
D [auth B]
IPR044389Non-structural protein 2, SARS-CoV-likeDomain
A,
B [auth D],
C,
D [auth B]
IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
A,
B [auth D],
C,
D [auth B]
IPR008740Peptidase C30, coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR036333RNA synthesis protein NSP10 superfamily, coronavirusHomologous Superfamily
A,
B [auth D],
C,
D [auth B]
IPR047573Non-structural protein 2, middle domain, coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR049894Coronavirus NSP3, 3Ecto domainDomain
A,
B [auth D],
C,
D [auth B]
IPR043472Macro domain-likeHomologous Superfamily
A,
B [auth D],
C,
D [auth B]
IPR043609NendoU domain, nidovirusDomain
A,
B [auth D],
C,
D [auth B]
IPR032592Non-structural protein NSP3, nucleic acid-binding domain, betacoronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR043613Non-structural protein 2, C-terminal domain, coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR038083Non-structural protein NSP3A domain-like superfamilyHomologous Superfamily
A,
B [auth D],
C,
D [auth B]
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
A,
B [auth D],
C,
D [auth B]
IPR044351RNA-dependent RNA polymerase, SARS-CoV-likeDomain
A,
B [auth D],
C,
D [auth B]
IPR024358Non-structural protein NSP3, N-terminal, betacoronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR048673Nonstructural protein 13, stalk domain, coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR046435NSP14, guanine-N7-methyltransferase domain, coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR009469RNA-dependent RNA polymerase, N-terminal, coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR043611Coronavirus replicase NSP3, C-terminalDomain
A,
B [auth D],
C,
D [auth B]
IPR044864Non-structural protein NSP3, SUD-N (Mac2) domain, betacoronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR047566Coronavirus replicase NSP3, Y domainDomain
A,
B [auth D],
C,
D [auth B]
IPR048672Nonstructural protein 13, zinc-binding domain, coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR043612Non-structural protein NSP4, N-terminal, coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
A,
B [auth D],
C,
D [auth B]
IPR043608Nonstructural protein 15, middle domain, coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR044353NSP3, second ubiquitin-like (Ubl) domain, coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR037204Non-structural protein NSP7 superfamily, coronavirusHomologous Superfamily
A,
B [auth D],
C,
D [auth B]
IPR046443NSP1, globular domain, alpha/betacoronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR043610Non-structural protein 6, coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR027351(+) RNA virus helicase core domainDomain
A,
B [auth D],
C,
D [auth B]
IPR044322Nonstructural protein 15, middle domain, alpha/betacoronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR009461Non-structural protein NSP16, coronavirus-likeDomain
A,
B [auth D],
C,
D [auth B]
IPR043477Peptidase C30, domain 3, coronavirusHomologous Superfamily
A,
B [auth D],
C,
D [auth B]
IPR043478Non-structural protein NSP3, SUD-N (Mac2) domain superfamily, betacoronavirusHomologous Superfamily
A,
B [auth D],
C,
D [auth B]
IPR038400Non-structural protein NSP3, SUD-M domain superfamily, betacoronavirusHomologous Superfamily
A,
B [auth D],
C,
D [auth B]
IPR046442NSP1, C-terminal domain, betacoronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR001205RNA-directed RNA polymerase, C-terminal domainDomain
A,
B [auth D],
C,
D [auth B]
IPR044401NSP15, NendoU domain, coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR014822Non-structural protein NSP9, coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR038030NSP1 globular domain superfamily, betacoronavirusHomologous Superfamily
A,
B [auth D],
C,
D [auth B]
IPR021590NSP1, globular domain, betacoronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR044367Non-structural protein 6, betacoronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR037230Non-structural protein NSP8 superfamily, coronavirusHomologous Superfamily
A,
B [auth D],
C,
D [auth B]
IPR046440Arterivirus Nsp11 N-terminal/Coronavirus NSP15 middle domainDomain
A,
B [auth D],
C,
D [auth B]
IPR032505Non-structural protein NSP4, C-terminal, coronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR046438Nidovirus 2-O-methyltransferaseDomain
A,
B [auth D],
C,
D [auth B]
IPR002589Macro domainDomain
A,
B [auth D],
C,
D [auth B]
IPR047567Non-structural protein NSP3, group 2-specific marker domain, betacoronavirusDomain
A,
B [auth D],
C,
D [auth B]
IPR044371Non-structural protein 3, X-domain-likeDomain
A,
B [auth D],
C,
D [auth B]
IPR007094RNA-directed RNA polymerase, catalytic domainDomain
E,
F [auth H],
G,
H [auth F]
IPR022733DPUP/SUD, C-terminal, betacoronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR042515Non-structural protein NSP15, N-terminal domain superfamily, coronavirusHomologous Superfamily
E,
F [auth H],
G,
H [auth F]
IPR043174Non-structural protein NSP15, middle domain superfamilyHomologous Superfamily
E,
F [auth H],
G,
H [auth F]
IPR044315Nonstructural protein 14, betacoronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR038123Non-structural protein NSP4, C-terminal superfamily, coronavirusHomologous Superfamily
E,
F [auth H],
G,
H [auth F]
IPR042570Non-structural protein NSP3, nucleic acid-binding domain superfamily, betacoronavirusHomologous Superfamily
E,
F [auth H],
G,
H [auth F]
IPR043178Papain-like protease, thumb domain superfamily, coronavirusHomologous Superfamily
E,
F [auth H],
G,
H [auth F]
IPR046441RNA-dependent RNA polymerase, coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR044863Nidovirus RdRp-associated nucleotidyl transferase (NiRAN) domainDomain
E,
F [auth H],
G,
H [auth F]
IPR044343Nonstructural protein 13, 1B domain, coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR038166Polyprotein cleavage domain PL2pro superfamily, betacoronavirusHomologous Superfamily
E,
F [auth H],
G,
H [auth F]
IPR037227Endoribonuclease EndoU-likeHomologous Superfamily
E,
F [auth H],
G,
H [auth F]
IPR027352Nonstructural protein 13, zinc-binding domain, coronavirus-likeDomain
E,
F [auth H],
G,
H [auth F]
IPR009003Peptidase S1, PA clanHomologous Superfamily
E,
F [auth H],
G,
H [auth F]
IPR013016Peptidase C16, coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR009466Non-structural protein 14, coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR044357NSP3, first ubiquitin-like (Ubl) domain, coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR046436Nidovirus 3'-5' exoribonuclease domainDomain
E,
F [auth H],
G,
H [auth F]
IPR047570NSP12, interface domain, coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR018995RNA synthesis protein NSP10, coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR043615Nonstructural protein 2, N-terminal domain, coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR050534Coronaviruses polyprotein 1abFamily
E,
F [auth H],
G,
H [auth F]
IPR043177Papain-like protease, N-terminal domain superfamily, coronavirusHomologous Superfamily
E,
F [auth H],
G,
H [auth F]
IPR043606Coronavirus replicase NSP15, N-terminal oligomerizationDomain
E,
F [auth H],
G,
H [auth F]
IPR044330Nonstructural protein 15, N-terminal domain, alpha/beta-coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR041679DNA2/NAM7 helicase-like, C-terminalDomain
E,
F [auth H],
G,
H [auth F]
IPR024375Non-structural protein NSP3, SUD-M domain, betacoronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR014828Non-structural protein NSP7, coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR043503Papain-like viral protease, palm and finger domains, coronavirusHomologous Superfamily
E,
F [auth H],
G,
H [auth F]
IPR014829Non-structural protein NSP8, coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR036499Non-structural protein NSP9 superfamily, coronavirusHomologous Superfamily
E,
F [auth H],
G,
H [auth F]
IPR029063S-adenosyl-L-methionine-dependent methyltransferase superfamilyHomologous Superfamily
E,
F [auth H],
G,
H [auth F]
IPR044389Non-structural protein 2, SARS-CoV-likeDomain
E,
F [auth H],
G,
H [auth F]
IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
E,
F [auth H],
G,
H [auth F]
IPR008740Peptidase C30, coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR036333RNA synthesis protein NSP10 superfamily, coronavirusHomologous Superfamily
E,
F [auth H],
G,
H [auth F]
IPR047573Non-structural protein 2, middle domain, coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR049894Coronavirus NSP3, 3Ecto domainDomain
E,
F [auth H],
G,
H [auth F]
IPR043472Macro domain-likeHomologous Superfamily
E,
F [auth H],
G,
H [auth F]
IPR043609NendoU domain, nidovirusDomain
E,
F [auth H],
G,
H [auth F]
IPR032592Non-structural protein NSP3, nucleic acid-binding domain, betacoronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR043613Non-structural protein 2, C-terminal domain, coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR038083Non-structural protein NSP3A domain-like superfamilyHomologous Superfamily
E,
F [auth H],
G,
H [auth F]
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
E,
F [auth H],
G,
H [auth F]
IPR044351RNA-dependent RNA polymerase, SARS-CoV-likeDomain
E,
F [auth H],
G,
H [auth F]
IPR024358Non-structural protein NSP3, N-terminal, betacoronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR048673Nonstructural protein 13, stalk domain, coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR046435NSP14, guanine-N7-methyltransferase domain, coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR009469RNA-dependent RNA polymerase, N-terminal, coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR043611Coronavirus replicase NSP3, C-terminalDomain
E,
F [auth H],
G,
H [auth F]
IPR044864Non-structural protein NSP3, SUD-N (Mac2) domain, betacoronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR047566Coronavirus replicase NSP3, Y domainDomain
E,
F [auth H],
G,
H [auth F]
IPR048672Nonstructural protein 13, zinc-binding domain, coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR043612Non-structural protein NSP4, N-terminal, coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
E,
F [auth H],
G,
H [auth F]
IPR043608Nonstructural protein 15, middle domain, coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR044353NSP3, second ubiquitin-like (Ubl) domain, coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR037204Non-structural protein NSP7 superfamily, coronavirusHomologous Superfamily
E,
F [auth H],
G,
H [auth F]
IPR046443NSP1, globular domain, alpha/betacoronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR043610Non-structural protein 6, coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR027351(+) RNA virus helicase core domainDomain
E,
F [auth H],
G,
H [auth F]
IPR044322Nonstructural protein 15, middle domain, alpha/betacoronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR009461Non-structural protein NSP16, coronavirus-likeDomain
E,
F [auth H],
G,
H [auth F]
IPR043477Peptidase C30, domain 3, coronavirusHomologous Superfamily
E,
F [auth H],
G,
H [auth F]
IPR043478Non-structural protein NSP3, SUD-N (Mac2) domain superfamily, betacoronavirusHomologous Superfamily
E,
F [auth H],
G,
H [auth F]
IPR038400Non-structural protein NSP3, SUD-M domain superfamily, betacoronavirusHomologous Superfamily
E,
F [auth H],
G,
H [auth F]
IPR046442NSP1, C-terminal domain, betacoronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR001205RNA-directed RNA polymerase, C-terminal domainDomain
E,
F [auth H],
G,
H [auth F]
IPR044401NSP15, NendoU domain, coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR014822Non-structural protein NSP9, coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR038030NSP1 globular domain superfamily, betacoronavirusHomologous Superfamily
E,
F [auth H],
G,
H [auth F]
IPR021590NSP1, globular domain, betacoronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR044367Non-structural protein 6, betacoronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR037230Non-structural protein NSP8 superfamily, coronavirusHomologous Superfamily
E,
F [auth H],
G,
H [auth F]
IPR046440Arterivirus Nsp11 N-terminal/Coronavirus NSP15 middle domainDomain
E,
F [auth H],
G,
H [auth F]
IPR032505Non-structural protein NSP4, C-terminal, coronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR046438Nidovirus 2-O-methyltransferaseDomain
E,
F [auth H],
G,
H [auth F]
IPR002589Macro domainDomain
E,
F [auth H],
G,
H [auth F]
IPR047567Non-structural protein NSP3, group 2-specific marker domain, betacoronavirusDomain
E,
F [auth H],
G,
H [auth F]
IPR044371Non-structural protein 3, X-domain-likeDomain
E,
F [auth H],
G,
H [auth F]
IPR007094RNA-directed RNA polymerase, catalytic domainDomain