7PSG

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	dCache_1_like_1	e7psgA1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: dCache_1_like_1	ECOD (1.6)
A	Cache_3-Cache_2	e7psgA2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: Cache_3-Cache_2	ECOD (1.6)
B	dCache_1_like_1	e7psgB1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: dCache_1_like_1	ECOD (1.6)
B	Cache_3-Cache_2	e7psgB2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: Cache_3-Cache_2	ECOD (1.6)
C	dCache_1_like_1	e7psgC2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: dCache_1_like_1	ECOD (1.6)
C	Cache_3-Cache_2	e7psgC1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: Cache_3-Cache_2	ECOD (1.6)
D	dCache_1_like_1	e7psgD1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: dCache_1_like_1	ECOD (1.6)
D	Cache_3-Cache_2	e7psgD2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: Cache_3-Cache_2	ECOD (1.6)

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF02743	Cache domain (dCache_1)	Cache domain	Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains [2]. This domain when present in chemoreceptor ...	Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains [2]. This domain when present in chemoreceptors recognise several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognises C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).	Domain

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Methyl-accepting chemotaxis protein	molecular transducer activity transmembrane signaling receptor activity signaling receptor activity	chemotaxis response to stimulus taxis response to chemical response to external stimulus locomotion cellular response to stimulus regulation of biological process regulation of cellular process signaling biological regulation cellular process signal transduction cell communication	cell periphery plasma membrane membrane cellular anatomical entity

Chains	Accession	Name	Type
A, B, C, D	IPR051310	Methyl-accepting chemotaxis	Family
A, B, C, D	IPR004090	Chemotaxis methyl-accepting receptor	Family
A, B, C, D	IPR033479	Double Cache domain 1	Domain
A, B, C, D	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain	Domain