Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AdCache_1_like_1e7psgA1 A: a+b three layersX: Profilin-likeH: sensor domains (From Topology)T: sensor domainsF: dCache_1_like_1ECOD (1.6)
ACache_3-Cache_2e7psgA2 A: a+b three layersX: Profilin-likeH: sensor domains (From Topology)T: sensor domainsF: Cache_3-Cache_2ECOD (1.6)
BdCache_1_like_1e7psgB1 A: a+b three layersX: Profilin-likeH: sensor domains (From Topology)T: sensor domainsF: dCache_1_like_1ECOD (1.6)
BCache_3-Cache_2e7psgB2 A: a+b three layersX: Profilin-likeH: sensor domains (From Topology)T: sensor domainsF: Cache_3-Cache_2ECOD (1.6)
CdCache_1_like_1e7psgC2 A: a+b three layersX: Profilin-likeH: sensor domains (From Topology)T: sensor domainsF: dCache_1_like_1ECOD (1.6)
CCache_3-Cache_2e7psgC1 A: a+b three layersX: Profilin-likeH: sensor domains (From Topology)T: sensor domainsF: Cache_3-Cache_2ECOD (1.6)
DdCache_1_like_1e7psgD1 A: a+b three layersX: Profilin-likeH: sensor domains (From Topology)T: sensor domainsF: dCache_1_like_1ECOD (1.6)
DCache_3-Cache_2e7psgD2 A: a+b three layersX: Profilin-likeH: sensor domains (From Topology)T: sensor domainsF: Cache_3-Cache_2ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D
PF02743Cache domain (dCache_1)Cache domainDouble cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains [2]. This domain when present in chemoreceptor ...Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains [2]. This domain when present in chemoreceptors recognise several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognises C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).
Domain