Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyMethyl-coenzyme M reductase subunits 8033123 3001305 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyMethyl-coenzyme M reductase alpha and beta chain C-terminal domain 8033121 3000812 SCOP2B (2022-06-29)
D [auth a]SCOP2B SuperfamilyMethyl-coenzyme M reductase alpha and beta chain C-terminal domain 8033121 3000812 SCOP2B (2022-06-29)
D [auth a]SCOP2B SuperfamilyMethyl-coenzyme M reductase subunits 8033123 3001305 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyMethyl-coenzyme M reductase subunits 8033111 3001305 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyMethyl-coenzyme M reductase alpha and beta chain C-terminal domain 8033109 3000812 SCOP2B (2022-06-29)
E [auth b]SCOP2B SuperfamilyMethyl-coenzyme M reductase subunits 8033111 3001305 SCOP2B (2022-06-29)
E [auth b]SCOP2B SuperfamilyMethyl-coenzyme M reductase alpha and beta chain C-terminal domain 8033109 3000812 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyMethyl-coenzyme M reductase subunits 8033112 3001305 SCOP2B (2022-06-29)
F [auth c]SCOP2B SuperfamilyMethyl-coenzyme M reductase subunits 8033112 3001305 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AMCR_alphae7sucA2 A: alpha bundlesX: Methyl-coenzyme M reductase alpha and beta chain-C (From Topology)H: Methyl-coenzyme M reductase alpha and beta chain-C (From Topology)T: Methyl-coenzyme M reductase alpha and beta chain-CF: MCR_alphaECOD (1.6)
AMCR_alpha_Ne7sucA1 A: a+b two layersX: Alpha-beta plaitsH: Methyl-coenzyme M reductase subunits (From Topology)T: Methyl-coenzyme M reductase subunitsF: MCR_alpha_NECOD (1.6)
D [auth a]MCR_alphae7suca1 A: alpha bundlesX: Methyl-coenzyme M reductase alpha and beta chain-C (From Topology)H: Methyl-coenzyme M reductase alpha and beta chain-C (From Topology)T: Methyl-coenzyme M reductase alpha and beta chain-CF: MCR_alphaECOD (1.6)
D [auth a]MCR_alpha_Ne7suca2 A: a+b two layersX: Alpha-beta plaitsH: Methyl-coenzyme M reductase subunits (From Topology)T: Methyl-coenzyme M reductase subunitsF: MCR_alpha_NECOD (1.6)
BMCR_betae7sucB1 A: alpha bundlesX: Methyl-coenzyme M reductase alpha and beta chain-C (From Topology)H: Methyl-coenzyme M reductase alpha and beta chain-C (From Topology)T: Methyl-coenzyme M reductase alpha and beta chain-CF: MCR_betaECOD (1.6)
BMCR_beta_Ne7sucB2 A: a+b two layersX: Alpha-beta plaitsH: Methyl-coenzyme M reductase subunits (From Topology)T: Methyl-coenzyme M reductase subunitsF: MCR_beta_NECOD (1.6)
E [auth b]MCR_betae7sucb2 A: alpha bundlesX: Methyl-coenzyme M reductase alpha and beta chain-C (From Topology)H: Methyl-coenzyme M reductase alpha and beta chain-C (From Topology)T: Methyl-coenzyme M reductase alpha and beta chain-CF: MCR_betaECOD (1.6)
E [auth b]MCR_beta_Ne7sucb1 A: a+b two layersX: Alpha-beta plaitsH: Methyl-coenzyme M reductase subunits (From Topology)T: Methyl-coenzyme M reductase subunitsF: MCR_beta_NECOD (1.6)
CMCR_gammae7sucC1 A: a+b two layersX: Alpha-beta plaitsH: Methyl-coenzyme M reductase subunits (From Topology)T: Methyl-coenzyme M reductase subunitsF: MCR_gammaECOD (1.6)
F [auth c]MCR_gammae7succ1 A: a+b two layersX: Alpha-beta plaitsH: Methyl-coenzyme M reductase subunits (From Topology)T: Methyl-coenzyme M reductase subunitsF: MCR_gammaECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A,
D [auth a]
PF02745Methyl-coenzyme M reductase alpha subunit, N-terminal domain (MCR_alpha_N)Methyl-coenzyme M reductase alpha subunit, N-terminal domainMethyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (this family), 2 beta (Pfam:PF02241), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active ...Methyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (this family), 2 beta (Pfam:PF02241), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active sites [1]. The N-terminal domain has a ferredoxin-like fold.
Domain
A,
D [auth a]
PF02249Methyl-coenzyme M reductase alpha subunit, C-terminal domain (MCR_alpha)Methyl-coenzyme M reductase alpha subunit, C-terminal domainMethyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (this family), 2 beta (Pfam:PF02241), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active ...Methyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (this family), 2 beta (Pfam:PF02241), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active sites [1]. The C-terminal domain is comprised of an all-alpha multi-helical bundle.
Domain
B,
E [auth b]
PF02241Methyl-coenzyme M reductase beta subunit, C-terminal domain (MCR_beta)Methyl-coenzyme M reductase beta subunit, C-terminal domainMethyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (Pfam:PF02249), 2 beta (this family), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active ...Methyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (Pfam:PF02249), 2 beta (this family), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active sites [1]. The C-terminal domain of MCR beta has an all-alpha fold with buried central helix.
Domain
B,
E [auth b]
PF02783Methyl-coenzyme M reductase beta subunit, N-terminal domain (MCR_beta_N)Methyl-coenzyme M reductase beta subunit, N-terminal domainMethyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (Pfam:PF02249), 2 beta (this family), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active ...Methyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (Pfam:PF02249), 2 beta (this family), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active sites [1]. The N-terminal domain has an alpha/beta ferredoxin-like fold.
Domain
C,
F [auth c]
PF02240Methyl-coenzyme M reductase gamma subunit (MCR_gamma)Methyl-coenzyme M reductase gamma subunitMethyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (Pfam:PF02249), 2 beta (Pfam:PF02241), and 2 gamma (this family) subunits with two identical nickel porphinoid activ ...Methyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (Pfam:PF02249), 2 beta (Pfam:PF02241), and 2 gamma (this family) subunits with two identical nickel porphinoid active sites [1].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A,
D [auth a]
Methyl-coenzyme M reductase I subunit alpha
B,
E [auth b]
Methyl-coenzyme M reductase I subunit beta
C,
F [auth c]
Methyl-coenzyme M reductase I subunit gamma

InterPro: Protein Family Classification InterPro Database Homepage

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
A,
D [auth a]
AGM Parent Component: ARG

RESIDAA0272

PSI-MOD :  5-methyl-L-arginine MOD:00277
A,
D [auth a]
DYA Parent Component: ASP

RESIDAA0272

A,
D [auth a]
GL3 Parent Component: GLY

RESIDAA0272 , AA0265

PSI-MOD :  5-methyl-L-arginine MOD:00277 , 1-thioglycine (internal) MOD:00270 , 1-thioglycine (C-terminal) MOD:01623
A,
D [auth a]
MGN Parent Component: GLN

RESIDAA0272 , AA0265 , AA0273

PSI-MOD :  5-methyl-L-arginine MOD:00277 , 1-thioglycine (internal) MOD:00270 , 1-thioglycine (C-terminal) MOD:01623 , 2-methyl-L-glutamine MOD:00278
A,
D [auth a]
MHS Parent Component: HIS

RESIDAA0272 , AA0265 , AA0273 , AA0073

PSI-MOD :  5-methyl-L-arginine MOD:00277 , 1-thioglycine (internal) MOD:00270 , 1-thioglycine (C-terminal) MOD:01623 , 2-methyl-L-glutamine MOD:00278 , 3'-methyl-L-histidine MOD:00082
A,
D [auth a]
SMC Parent Component: CYS

RESIDAA0272 , AA0265 , AA0273 , AA0073 , AA0234

PSI-MOD :  5-methyl-L-arginine MOD:00277 , 1-thioglycine (internal) MOD:00270 , 1-thioglycine (C-terminal) MOD:01623 , 2-methyl-L-glutamine MOD:00278 , 3'-methyl-L-histidine MOD:00082 , S-methyl-L-cysteine MOD:00239