8CAC

Crystal structure of SARS-CoV-2 Mpro-H172Y mutant in complex with 13b-K

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth AAA], B [auth BBB]	PF05409	Coronavirus endopeptidase C30 (Peptidase_C30)	Coronavirus endopeptidase C30	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth AAA], B [auth BBB]	3C-like proteinase nsp5	peptidase activity omega peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity transferase activity, transferring one-carbon groups transferase activity methyltransferase activity endonuclease activity nuclease activity hydrolase activity, acting on ester bonds cysteine-type peptidase activity ubiquitin-like protein peptidase activity ISG15-specific peptidase activity peptidase activity omega peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity transferase activity, transferring one-carbon groups transferase activity methyltransferase activity endonuclease activity nuclease activity hydrolase activity, acting on ester bonds cysteine-type peptidase activity ubiquitin-like protein peptidase activity ISG15-specific peptidase activity cysteine-type endopeptidase activity endopeptidase activity RNA binding binding organic cyclic compound binding nucleic acid binding single-stranded RNA binding cysteine-type deubiquitinase activity deubiquitinase activity G-quadruplex RNA binding lipid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms response to stimulus symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway response to biotic stimulus biological process involved in symbiotic interaction symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response symbiont-mediated perturbation of host process response to host immune response symbiont-mediated suppression of host defenses symbiont-mediated perturbation of host innate immune response response to host response to external biotic stimulus symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms response to stimulus symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway response to biotic stimulus biological process involved in symbiotic interaction symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response symbiont-mediated perturbation of host process response to host immune response symbiont-mediated suppression of host defenses symbiont-mediated perturbation of host innate immune response response to host response to external biotic stimulus symbiont-mediated perturbation of host signal transduction pathway modulation of process of another organism symbiont-mediated perturbation of host defense response response to host defenses response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism symbiont-mediated perturbation of host defenses response to external stimulus biological process involved in interaction with host symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity symbiont-mediated suppression of host signal transduction pathway cellular process symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway methylation metabolic process symbiont-mediated suppression of host ISG15-protein conjugation viral gene expression viral protein processing viral process regulation of cellular process negative regulation of biological process symbiont-mediated perturbation of host translation negative regulation of cellular metabolic process nucleobase-containing compound metabolic process symbiont-mediated suppression of host gene expression RNA catabolic process mRNA catabolic process regulation of biological process cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process primary metabolic process negative regulation of cellular biosynthetic process nucleobase-containing compound catabolic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process symbiont-mediated degradation of host mRNA nucleic acid catabolic process symbiont-mediated suppression of host translation regulation of macromolecule biosynthetic process symbiont-mediated perturbation of host gene expression macromolecule metabolic process regulation of metabolic process catabolic process cellular biosynthetic process RNA metabolic process macromolecule catabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process mRNA metabolic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process modulation by virus of host process virus-mediated perturbation of host defense response modulation by virus of host cellular process symbiont-mediated perturbation of host ubiquitin-like protein modification autophagy positive regulation of biological process positive regulation of cellular metabolic process regulation of autophagy cellular catabolic process positive regulation of metabolic process induction by virus of host autophagy process utilizing autophagic mechanism positive regulation of cellular process positive regulation of autophagy modulation by virus of host autophagy regulation of catabolic process positive regulation of catabolic process regulation of cellular catabolic process positive regulation of cellular catabolic process symbiont-mediated suppression of host type I interferon-mediated signaling pathway symbiont-mediated suppression of host interferon-mediated signaling pathway viral genome replication viral life cycle viral translational frameshifting viral translation proteolysis protein metabolic process	membrane cellular anatomical entity host intracellular membrane-bounded organelle host cellular component host intracellular part host cell endoplasmic reticulum host cell membrane host cell cytoplasm part host intracellular organelle host cell cytoplasm host cell part host cell endomembrane system host intracellular region host cell endoplasmic reticulum membrane membrane cellular anatomical entity host intracellular membrane-bounded organelle host cellular component host intracellular part host cell endoplasmic reticulum host cell membrane host cell cytoplasm part host intracellular organelle host cell cytoplasm host cell part host cell endomembrane system host intracellular region host cell endoplasmic reticulum membrane cytoplasmic viral factory double membrane vesicle viral factory membrane host cell cytoplasmic vesicle membrane host cell cytoplasmic vesicle viral factory double membrane vesicle viral factory outer membrane double membrane vesicle viral factory host cell perinuclear region of cytoplasm host cell Golgi apparatus host cell endosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth AAA], B [auth BBB]	IPR022733	DPUP/SUD, C-terminal, betacoronavirus	Domain
A [auth AAA], B [auth BBB]	IPR024358	Non-structural protein NSP3, N-terminal, betacoronavirus	Domain
A [auth AAA], B [auth BBB]	IPR043611	Coronavirus replicase NSP3, C-terminal	Domain
A [auth AAA], B [auth BBB]	IPR044864	Non-structural protein NSP3, SUD-N (Mac2) domain, betacoronavirus	Domain
A [auth AAA], B [auth BBB]	IPR038123	Non-structural protein NSP4, C-terminal superfamily, coronavirus	Homologous Superfamily
A [auth AAA], B [auth BBB]	IPR042570	Non-structural protein NSP3, nucleic acid-binding domain superfamily, betacoronavirus	Homologous Superfamily
A [auth AAA], B [auth BBB]	IPR047566	Coronavirus replicase NSP3, Y domain	Domain
A [auth AAA], B [auth BBB]	IPR043178	Papain-like protease, thumb domain superfamily, coronavirus	Homologous Superfamily
A [auth AAA], B [auth BBB]	IPR043612	Non-structural protein NSP4, N-terminal, coronavirus	Domain
A [auth AAA], B [auth BBB]	IPR038166	Polyprotein cleavage domain PL2pro superfamily, betacoronavirus	Homologous Superfamily
A [auth AAA], B [auth BBB]	IPR044353	NSP3, second ubiquitin-like (Ubl) domain, coronavirus	Domain
A [auth AAA], B [auth BBB]	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A [auth AAA], B [auth BBB]	IPR013016	Peptidase C16, coronavirus	Domain
A [auth AAA], B [auth BBB]	IPR037204	Non-structural protein NSP7 superfamily, coronavirus	Homologous Superfamily
A [auth AAA], B [auth BBB]	IPR044357	NSP3, first ubiquitin-like (Ubl) domain, coronavirus	Domain
A [auth AAA], B [auth BBB]	IPR046443	NSP1, globular domain, alpha/betacoronavirus	Domain
A [auth AAA], B [auth BBB]	IPR043610	Non-structural protein 6, coronavirus	Domain
A [auth AAA], B [auth BBB]	IPR043477	Peptidase C30, domain 3, coronavirus	Homologous Superfamily
A [auth AAA], B [auth BBB]	IPR018995	RNA synthesis protein NSP10, coronavirus	Domain
A [auth AAA], B [auth BBB]	IPR043478	Non-structural protein NSP3, SUD-N (Mac2) domain superfamily, betacoronavirus	Homologous Superfamily
A [auth AAA], B [auth BBB]	IPR038400	Non-structural protein NSP3, SUD-M domain superfamily, betacoronavirus	Homologous Superfamily
A [auth AAA], B [auth BBB]	IPR046442	NSP1, C-terminal domain, betacoronavirus	Domain
A [auth AAA], B [auth BBB]	IPR043615	Nonstructural protein 2, N-terminal domain, coronavirus	Domain
A [auth AAA], B [auth BBB]	IPR043177	Papain-like protease, N-terminal domain superfamily, coronavirus	Homologous Superfamily
A [auth AAA], B [auth BBB]	IPR014822	Non-structural protein NSP9, coronavirus	Domain
A [auth AAA], B [auth BBB]	IPR038030	NSP1 globular domain superfamily, betacoronavirus	Homologous Superfamily
A [auth AAA], B [auth BBB]	IPR021590	NSP1, globular domain, betacoronavirus	Domain
A [auth AAA], B [auth BBB]	IPR024375	Non-structural protein NSP3, SUD-M domain, betacoronavirus	Domain
A [auth AAA], B [auth BBB]	IPR044367	Non-structural protein 6, betacoronavirus	Domain
A [auth AAA], B [auth BBB]	IPR037230	Non-structural protein NSP8 superfamily, coronavirus	Homologous Superfamily
A [auth AAA], B [auth BBB]	IPR014828	Non-structural protein NSP7, coronavirus	Domain
A [auth AAA], B [auth BBB]	IPR032505	Non-structural protein NSP4, C-terminal, coronavirus	Domain
A [auth AAA], B [auth BBB]	IPR043503	Papain-like viral protease, palm and finger domains, coronavirus	Homologous Superfamily
A [auth AAA], B [auth BBB]	IPR014829	Non-structural protein NSP8, coronavirus	Domain
A [auth AAA], B [auth BBB]	IPR036499	Non-structural protein NSP9 superfamily, coronavirus	Homologous Superfamily
A [auth AAA], B [auth BBB]	IPR002589	Macro domain	Domain
A [auth AAA], B [auth BBB]	IPR047567	Non-structural protein NSP3, group 2-specific marker domain, betacoronavirus	Domain
A [auth AAA], B [auth BBB]	IPR044389	Non-structural protein 2, SARS-CoV-like	Domain
A [auth AAA], B [auth BBB]	IPR008740	Peptidase C30, coronavirus	Domain
A [auth AAA], B [auth BBB]	IPR036333	RNA synthesis protein NSP10 superfamily, coronavirus	Homologous Superfamily
A [auth AAA], B [auth BBB]	IPR047573	Non-structural protein 2, middle domain, coronavirus	Domain
A [auth AAA], B [auth BBB]	IPR049894	Coronavirus NSP3, 3Ecto domain	Domain
A [auth AAA], B [auth BBB]	IPR043472	Macro domain-like	Homologous Superfamily
A [auth AAA], B [auth BBB]	IPR044371	Non-structural protein 3, X-domain-like	Domain
A [auth AAA], B [auth BBB]	IPR032592	Non-structural protein NSP3, nucleic acid-binding domain, betacoronavirus	Domain
A [auth AAA], B [auth BBB]	IPR043613	Non-structural protein 2, C-terminal domain, coronavirus	Domain
A [auth AAA], B [auth BBB]	IPR038083	Non-structural protein NSP3A domain-like superfamily	Homologous Superfamily
A [auth AAA], B [auth BBB]	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily