Annotations: 8DHU

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF21071	LARP1 HEAT repeat region (LARP1_HEAT)	LARP1 HEAT repeat region	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	La-related protein 1	poly-pyrimidine tract binding RNA binding binding organic cyclic compound binding nucleic acid binding single-stranded RNA binding mRNA 5'-UTR binding mRNA binding RNA cap binding	positive regulation of mitochondrial DNA metabolic process positive regulation of organelle organization regulation of cellular process positive regulation of cellular component organization regulation of cellular component organization positive regulation of DNA replication positive regulation of biological process mitochondrial genome maintenance positive regulation of mitochondrial DNA replication mitochondrial DNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process cellular component organization positive regulation of metabolic process positive regulation of mitochondrial DNA metabolic process positive regulation of organelle organization regulation of cellular process positive regulation of cellular component organization regulation of cellular component organization positive regulation of DNA replication positive regulation of biological process mitochondrial genome maintenance positive regulation of mitochondrial DNA replication mitochondrial DNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process cellular component organization positive regulation of metabolic process positive regulation of macromolecule metabolic process cellular component organization or biogenesis regulation of nucleobase-containing compound metabolic process positive regulation of cellular process mitochondrion organization regulation of biological process positive regulation of nucleobase-containing compound metabolic process DNA-templated DNA replication biological regulation primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of organelle organization organelle organization DNA replication positive regulation of DNA metabolic process mitochondrial DNA replication regulation of mitochondrion organization regulation of DNA-templated DNA replication positive regulation of DNA-templated DNA replication metabolic process cellular process regulation of mitochondrial DNA replication macromolecule metabolic process regulation of metabolic process regulation of mitochondrial DNA metabolic process regulation of DNA metabolic process regulation of DNA replication negative regulation of biological process post-transcriptional regulation of gene expression negative regulation of translation negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of protein metabolic process negative regulation of metabolic process translation gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of cytoplasmic translation negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process cytoplasmic translation regulation of macromolecule biosynthetic process regulation of cytoplasmic translation positive regulation of protein metabolic process positive regulation of translation positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process positive regulation of gene expression mitochondrion distribution localization mitochondrion localization organelle localization organelle inheritance mitochondrion inheritance positive regulation of cytoplasmic translation developmental process syncytial blastoderm mitotic cell cycle multicellular organismal process embryo development mitotic cell cycle mitotic cell cycle, embryonic multicellular organism development anatomical structure development cell cycle cell cycle comprising mitosis without cytokinesis sexual reproduction reproductive process organelle fission meiotic cell cycle male meiotic nuclear division multicellular organismal reproductive process meiotic cell cycle process male gamete generation gamete generation nuclear division meiotic nuclear division cell cycle process regulation of RNA metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process mRNA stabilization mRNA catabolic process nucleobase-containing compound catabolic process nucleic acid catabolic process negative regulation of RNA metabolic process catabolic process RNA metabolic process macromolecule catabolic process negative regulation of mRNA metabolic process regulation of mRNA catabolic process negative regulation of catabolic process negative regulation of mRNA catabolic process negative regulation of RNA catabolic process regulation of catabolic process mRNA metabolic process regulation of mRNA stability RNA stabilization regulation of RNA stability regulation of mRNA metabolic process protein localization regulation of localization establishment of protein localization cellular localization regulation of protein localization protein targeting regulation of protein targeting to mitochondrion positive regulation of establishment of protein localization cellular macromolecule localization positive regulation of protein targeting to mitochondrion regulation of establishment of protein localization establishment of localization regulation of establishment of protein localization to mitochondrion establishment of protein localization to organelle regulation of protein targeting regulation of cellular localization macromolecule localization protein localization to organelle protein localization to mitochondrion positive regulation of protein localization protein targeting to mitochondrion establishment of protein localization to mitochondrion positive regulation of establishment of protein localization to mitochondrion meiotic chromosome segregation microtubule cytoskeleton organization membraneless organelle assembly cellular component biogenesis cellular component assembly chromosome segregation spindle organization organelle assembly meiotic spindle organization meiotic spindle assembly spindle assembly spindle assembly involved in male meiosis nuclear chromosome segregation microtubule-based process cytoskeleton organization	intracellular anatomical structure cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule intracellular organelle cellular anatomical structure organelle membraneless organelle cytoplasm supramolecular complex cytoplasmic stress granule cytosol membrane-bounded organelle mitochondrial membrane intracellular anatomical structure cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule intracellular organelle cellular anatomical structure organelle membraneless organelle cytoplasm supramolecular complex cytoplasmic stress granule cytosol membrane-bounded organelle mitochondrial membrane mitochondrion membrane extrinsic component of organelle membrane organelle outer membrane intracellular membrane-bounded organelle organelle envelope extrinsic component of mitochondrial outer membrane bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane extrinsic component of membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A, B	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A, B	IPR006607	LARP1-like, DM15 repeat	Repeat
A, B	IPR006630	La-type HTH domain	Domain
A, B	IPR045180	La domain containing protein	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.