Annotations: 8E1S

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	RimK	e8e1sA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: ATP-grasp	F: RimK	ECOD (1.6)
A	KOG1057	e8e1sA2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: PreATP-grasp domain	F: KOG1057	ECOD (1.6)
B	RimK	e8e1sB1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: ATP-grasp	F: RimK	ECOD (1.6)
B	KOG1057	e8e1sB2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: PreATP-grasp domain	F: KOG1057	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF08443	RimK-like ATP-grasp domain (RimK)	RimK-like ATP-grasp domain	This ATP-grasp domain is found in the ribosomal S6 modification enzyme RimK [1].	Domain
A, B	PF18086	Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain (PPIP5K2_N)	Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain	This is the N-terminal domain found in the Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (PPIP5K2), EC:2.7.4.24. Structure analysis of human PPIP5K2 indicate that this region forms alpha-beta-alpha domain [1].PPIP5K2 is o ...	This is the N-terminal domain found in the Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (PPIP5K2), EC:2.7.4.24. Structure analysis of human PPIP5K2 indicate that this region forms alpha-beta-alpha domain [1].PPIP5K2 is one of the mammalian PPIP5K isoforms responsible for synthesis of diphosphoinositol polyphosphates (inositol pyrophosphates; PP-InsPs), regulatory molecules that function at the interface of cell signaling and organismic homeostasis [3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase	inositol-1,3,4,5,6-pentakisphosphate kinase activity kinase activity transferase activity inositol phosphate kinase activity catalytic activity phosphotransferase activity, phosphate group as acceptor transferase activity, transferring phosphorus-containing groups inositol hexakisphosphate 5-kinase activity inositol hexakisphosphate kinase activity diphosphoinositol pentakisphosphate kinase activity inositol hexakisphosphate 1-kinase activity binding adenyl ribonucleotide binding nucleotide binding inositol-1,3,4,5,6-pentakisphosphate kinase activity kinase activity transferase activity inositol phosphate kinase activity catalytic activity phosphotransferase activity, phosphate group as acceptor transferase activity, transferring phosphorus-containing groups inositol hexakisphosphate 5-kinase activity inositol hexakisphosphate kinase activity diphosphoinositol pentakisphosphate kinase activity inositol hexakisphosphate 1-kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding metal cluster binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides ATP-dependent activity inositol diphosphate pentakisphosphate diphosphatase activity inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity diphosphoinositol-polyphosphate diphosphatase activity inositol hexakisphosphate 3-kinase activity inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity inositol bisdiphosphate tetrakisphosphate diphosphatase activity 5-diphosphoinositol pentakisphosphate 1-kinase activity	polyol metabolic process inositol metabolic process organic hydroxy compound metabolic process alcohol metabolic process small molecule metabolic process metabolic process cellular process regulation of chromosome segregation regulation of cytoskeleton organization regulation of cellular process regulation of cellular component organization mitotic spindle elongation spindle elongation microtubule cytoskeleton organization polyol metabolic process inositol metabolic process organic hydroxy compound metabolic process alcohol metabolic process small molecule metabolic process metabolic process cellular process regulation of chromosome segregation regulation of cytoskeleton organization regulation of cellular process regulation of cellular component organization mitotic spindle elongation spindle elongation microtubule cytoskeleton organization regulation of mitotic spindle organization mitotic cell cycle regulation of mitotic spindle elongation (spindle phase three) cellular component organization mitotic spindle elongation (spindle phase three) mitotic sister chromatid segregation regulation of spindle elongation cell cycle cellular component organization or biogenesis regulation of cell cycle chromosome segregation microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process mitotic nuclear division regulation of biological process regulation of cell cycle process organelle fission biological regulation regulation of microtubule-based process chromosome organization sister chromatid segregation regulation of chromosome organization regulation of spindle organization regulation of organelle organization mitotic spindle organization organelle organization nuclear division regulation of mitotic sister chromatid segregation mitotic cell cycle process regulation of sister chromatid segregation nuclear chromosome segregation regulation of mitotic spindle elongation microtubule-based process cytoskeleton organization regulation of microtubule cytoskeleton organization phosphate ion homeostasis intracellular phosphate ion homeostasis cellular homeostasis inorganic ion homeostasis chemical homeostasis homeostatic process intracellular chemical homeostasis organophosphate metabolic process phosphate-containing compound metabolic process inositol phosphate metabolic process phosphorus metabolic process alcohol catabolic process catabolic process polyol catabolic process organophosphate catabolic process organic hydroxy compound catabolic process inositol phosphate catabolic process small molecule catabolic process small molecule biosynthetic process biosynthetic process organophosphate biosynthetic process inositol phosphate biosynthetic process organic hydroxy compound biosynthetic process polyol biosynthetic process alcohol biosynthetic process regulation of growth regulation of developmental process developmental growth unidimensional cell growth cell morphogenesis cell growth regulation of cell morphogenesis anatomical structure development regulation of bipolar cell growth regulation of anatomical structure morphogenesis developmental process bipolar cell growth regulation of developmental growth growth regulation of cell growth developmental growth involved in morphogenesis regulation of unidimensional cell growth anatomical structure morphogenesis membraneless organelle assembly cellular component biogenesis cellular component assembly organelle assembly spindle assembly mitotic spindle assembly signaling	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol intracellular organelle cytoskeleton organelle membraneless organelle intracellular membraneless organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000560	Histidine phosphatase superfamily, clade-2	Family
A, B	IPR037446	Histidine acid phosphatase, VIP1 family	Family
A, B	IPR029033	Histidine phosphatase superfamily	Homologous Superfamily
A, B	IPR013651	ATP-grasp fold, RimK-type	Domain
A, B	IPR040557	VIP1, N-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.