8EK9

Crystal structure of the class A carbapenemase CRH-1 in complex with avibactam at 1.4 Angstrom resolution

External Resource: Annotation


AMR Gene Family: CARD Annotation CARD Database Homepage

ChainsAccessionGene FamilyDrug Class Resistance MachanismProvenance Source (Version)
ARO:3005399CRH beta-lactamasecarbapenemantibiotic inactivationCARD (3.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF13354Beta-lactamase enzyme family (Beta-lactamase2)Beta-lactamase enzyme familyThis is the catalytic domain of class A beta-lactamases [1]. It is closely related to Beta-lactamase, Pfam:PF00144, the serine beta-lactamase-like superfamily, which contains the distantly related Pfam:PF00905 and PF00768 D-alanyl-D-alanine carboxype ...This is the catalytic domain of class A beta-lactamases [1]. It is closely related to Beta-lactamase, Pfam:PF00144, the serine beta-lactamase-like superfamily, which contains the distantly related Pfam:PF00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.
Domain
PF00144Beta-lactamase (Beta-lactamase)Beta-lactamaseThis family appears to be distantly related to Pfam:PF00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Beta-lactamase -

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR045155Beta-lactamase class A, catalytic domainDomain
IPR012338Beta-lactamase/transpeptidase-likeHomologous Superfamily
IPR000871Beta-lactamase, class-AFamily