8G2G

Crystal structure of PRMT3 with compound YD1113

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8041509	3000118	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Arginine methyltransferase C-terminal oligomerisation domain-like	8053431	3002184	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Arginine methyltransferase C-terminal oligomerisation domain-like	8053431	3002184	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8041509	3000118	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e8g2gA2	A: beta sandwiches	X: Arginine methyltransferase oligomerization subdomain (From Topology)	H: Arginine methyltransferase oligomerization subdomain (From Topology)	T: Arginine methyltransferase oligomerization subdomain	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e8g2gA1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e8g2gB2	A: beta sandwiches	X: Arginine methyltransferase oligomerization subdomain (From Topology)	H: Arginine methyltransferase oligomerization subdomain (From Topology)	T: Arginine methyltransferase oligomerization subdomain	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e8g2gB1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF22528	Arginine methyltransferase oligomerization subdomain (PRMT_C)	Arginine methyltransferase oligomerization subdomain	This entry represents a domain found C-terminal in protein arginine methyltransferases. This domain is involved in oligomerisation.	Domain
A, B	PF06325	Ribosomal protein L11 methyltransferase (PrmA) (PrmA)	Ribosomal protein L11 methyltransferase (PrmA)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Protein arginine N-methyltransferase 3	catalytic activity, acting on a protein transferase activity, transferring one-carbon groups protein methyltransferase activity histone modifying activity transferase activity methyltransferase activity catalytic activity histone methyltransferase activity arginine N-methyltransferase activity N-methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity protein-arginine N-methyltransferase activity protein-arginine omega-N monomethyltransferase activity ribonucleoprotein complex binding catalytic activity, acting on a protein transferase activity, transferring one-carbon groups protein methyltransferase activity histone modifying activity transferase activity methyltransferase activity catalytic activity histone methyltransferase activity arginine N-methyltransferase activity N-methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity protein-arginine N-methyltransferase activity protein-arginine omega-N monomethyltransferase activity ribonucleoprotein complex binding protein-containing complex binding binding ribosome binding protein-arginine omega-N asymmetric methyltransferase activity cation binding ion binding metal ion binding small molecule binding	negative regulation of post-translational protein modification regulation of cellular process regulation of protein modification process negative regulation of biological process regulation of protein ubiquitination regulation of primary metabolic process protein ubiquitination negative regulation of protein modification process negative regulation of cellular process protein metabolic process negative regulation of protein ubiquitination regulation of protein modification by small protein conjugation or removal protein modification process negative regulation of protein metabolic process negative regulation of post-translational protein modification regulation of cellular process regulation of protein modification process negative regulation of biological process regulation of protein ubiquitination regulation of primary metabolic process protein ubiquitination negative regulation of protein modification process negative regulation of cellular process protein metabolic process negative regulation of protein ubiquitination regulation of protein modification by small protein conjugation or removal protein modification process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biological process negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification regulation of protein metabolic process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process macromolecule modification metabolic process cellular process macromolecule metabolic process post-translational protein modification regulation of metabolic process protein modification by small protein conjugation protein modification by small protein conjugation or removal methylation diterpenoid metabolic process negative regulation of small molecule metabolic process oxoacid metabolic process regulation of lipid metabolic process organic acid biosynthetic process organic acid metabolic process terpenoid biosynthetic process negative regulation of lipid biosynthetic process carboxylic acid biosynthetic process regulation of small molecule metabolic process retinoic acid metabolic process small molecule metabolic process regulation of biological quality regulation of vitamin metabolic process regulation of hormone levels regulation of ketone metabolic process negative regulation of vitamin metabolic process retinoic acid biosynthetic process biosynthetic process negative regulation of isoprenoid metabolic process regulation of isoprenoid metabolic process monocarboxylic acid metabolic process negative regulation of lipid metabolic process terpenoid metabolic process negative regulation of hormone metabolic process isoprenoid metabolic process regulation of hormone metabolic process ketone metabolic process lipid biosynthetic process regulation of biosynthetic process monocarboxylic acid biosynthetic process small molecule biosynthetic process isoprenoid biosynthetic process carboxylic acid metabolic process regulation of retinoic acid biosynthetic process hormone metabolic process vitamin metabolic process diterpenoid biosynthetic process negative regulation of retinoic acid biosynthetic process negative regulation of biosynthetic process retinoid metabolic process regulation of lipid biosynthetic process lipid metabolic process cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR049482	Protein arginine N-methyltransferase 3-like, C2H2 zinc finger domain	Domain
A, B	IPR025799	Protein arginine N-methyltransferase	Family
A, B	IPR013087	Zinc finger C2H2-type	Domain
A, B	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
A, B	IPR036236	Zinc finger C2H2 superfamily	Homologous Superfamily
A, B	IPR049009	Protein arginine N-methyltransferase 3, C2H2 zinc finger	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: O60678	atypical teratoid rhabdoid tumor lung cancer malignant glioma non-small cell lung carcinoma glioblastoma lung carcinoma malignant mesothelioma ovarian cancer large cell medulloblastoma malignant ependymoma nasopharyngeal carcinoma pituitary cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.