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Data API
8GL7
AncAR1 - progesterone - Tif2
External Resource: Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Gene Ontology: Gene Product Annotation
Gene Ontology Database Homepage
Chains
Polymer
Molecular Function
Biological Process
Cellular Component
A
Ancestral androgen receptor
-
-
-
B [auth D]
Nuclear receptor coactivator 2
protein binding
binding
protein domain specific binding
DNA binding
sequence-specific DNA binding
double-stranded DNA binding
nucleic acid binding
RNA polymerase II transcription regulatory region sequence-specific DNA binding
cis-regulatory region sequence-specific DNA binding
sequence-specific double-stranded DNA binding
transcription cis-regulatory region binding
organic cyclic compound binding
transcription regulatory region nucleic acid binding
RNA polymerase II cis-regulatory region sequence-specific DNA binding
protein binding
binding
protein domain specific binding
DNA binding
sequence-specific DNA binding
double-stranded DNA binding
nucleic acid binding
RNA polymerase II transcription regulatory region sequence-specific DNA binding
cis-regulatory region sequence-specific DNA binding
sequence-specific double-stranded DNA binding
transcription cis-regulatory region binding
organic cyclic compound binding
transcription regulatory region nucleic acid binding
RNA polymerase II cis-regulatory region sequence-specific DNA binding
chromatin binding
transcription coactivator activity
transcription regulator activity
transcription coregulator activity
protein-macromolecule adaptor activity
molecular adaptor activity
transcription factor binding
RNA polymerase II-specific DNA-binding transcription factor binding
nuclear receptor binding
DNA-binding transcription factor binding
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
intronic transcription regulatory region sequence-specific DNA binding
nuclear receptor coactivator activity
protein dimerization activity
signaling receptor binding
aryl hydrocarbon receptor binding
Less
regulation of biological process
regulation of lipid metabolic process
biological regulation
primary metabolic process
metabolic process
regulation of metabolic process
lipid metabolic process
regulation of primary metabolic process
developmental process
multicellular organismal process
regulation of developmental process
connective tissue development
adipose tissue development
positive regulation of adipose tissue development
regulation of biological process
regulation of lipid metabolic process
biological regulation
primary metabolic process
metabolic process
regulation of metabolic process
lipid metabolic process
regulation of primary metabolic process
developmental process
multicellular organismal process
regulation of developmental process
connective tissue development
adipose tissue development
positive regulation of adipose tissue development
animal organ development
positive regulation of biological process
tissue development
positive regulation of developmental process
regulation of adipose tissue development
anatomical structure development
positive regulation of multicellular organismal process
regulation of multicellular organismal process
response to ketone
response to lipid
response to stimulus
response to hormone
response to steroid hormone
response to chemical
response to endogenous stimulus
response to progesterone
response to oxygen-containing compound
response to organic cyclic compound
cellular response to stimulus
cellular response to endogenous stimulus
cellular response to chemical stimulus
cellular process
cellular response to hormone stimulus
regulation of biosynthetic process
rhythmic process
regulation of cellular process
circadian regulation of gene expression
cellular biosynthetic process
cellular metabolic process
circadian rhythm
regulation of cellular metabolic process
regulation of macromolecule metabolic process
gene expression
macromolecule biosynthetic process
regulation of cellular biosynthetic process
regulation of gene expression
biosynthetic process
regulation of macromolecule biosynthetic process
macromolecule metabolic process
RNA metabolic process
nucleobase-containing compound metabolic process
RNA biosynthetic process
nucleic acid biosynthetic process
DNA-templated transcription
regulation of RNA metabolic process
regulation of nucleobase-containing compound metabolic process
regulation of RNA biosynthetic process
nucleobase-containing compound biosynthetic process
nucleic acid metabolic process
regulation of DNA-templated transcription
intracellular receptor signaling pathway
signaling
intracellular signal transduction
cell communication
peroxisome proliferator activated receptor signaling pathway
signal transduction
nuclear receptor-mediated signaling pathway
mRNA transcription by RNA polymerase II
mRNA transcription
mRNA metabolic process
transcription by RNA polymerase II
behavior
circadian behavior
locomotory behavior
rhythmic behavior
locomotor rhythm
response to Thyroglobulin triiodothyronine
cellular response to Thyroglobulin triiodothyronine
negative regulation of biological process
negative regulation of cellular metabolic process
negative regulation of RNA biosynthetic process
negative regulation of cellular process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule metabolic process
regulation of transcription by RNA polymerase II
negative regulation of DNA-templated transcription
negative regulation of transcription by RNA polymerase II
negative regulation of metabolic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
negative regulation of macromolecule biosynthetic process
negative regulation of RNA metabolic process
cellular response to nitrogen compound
response to peptide hormone
cellular response to peptide hormone stimulus
response to nitrogen compound
regulation of cellular response to insulin stimulus
cellular response to oxygen-containing compound
regulation of response to stimulus
response to insulin
cellular response to insulin stimulus
positive regulation of DNA-templated transcription
positive regulation of cellular metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of metabolic process
positive regulation of biosynthetic process
positive regulation of macromolecule metabolic process
positive regulation of cellular process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of transcription by RNA polymerase II
positive regulation of RNA metabolic process
positive regulation of RNA biosynthetic process
positive regulation of cellular biosynthetic process
monosaccharide metabolic process
carbohydrate metabolic process
hexose metabolic process
regulation of small molecule metabolic process
small molecule metabolic process
regulation of carbohydrate metabolic process
regulation of glucose metabolic process
glucose metabolic process
Less
RNA polymerase II transcription regulator complex
membrane-bounded organelle
protein-containing complex
intracellular anatomical structure
nucleus
nuclear protein-containing complex
transcription regulator complex
intracellular membrane-bounded organelle
cellular anatomical entity
intracellular organelle
organelle
cytoplasm
membrane-enclosed lumen
intracellular organelle lumen
RNA polymerase II transcription regulator complex
membrane-bounded organelle
protein-containing complex
intracellular anatomical structure
nucleus
nuclear protein-containing complex
transcription regulator complex
intracellular membrane-bounded organelle
cellular anatomical entity
intracellular organelle
organelle
cytoplasm
membrane-enclosed lumen
intracellular organelle lumen
nucleoplasm
organelle lumen
nuclear lumen
intracellular non-membrane-bounded organelle
chromatin
chromosome
non-membrane-bounded organelle
nuclear body
Less
InterPro: Protein Family Classification
InterPro Database Homepage
Chains
Accession
Name
Type
B [auth D]
IPR010011
Nuclear receptor coactivator, DUF1518
Domain
B [auth D]
IPR009110
Nuclear receptor coactivator, interlocking
Homologous Superfamily
B [auth D]
IPR037077
Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily
Homologous Superfamily
B [auth D]
IPR017426
Nuclear receptor coactivator
Family
B [auth D]
IPR014935
Nuclear receptor coactivator, receptor-binding domain
Domain
B [auth D]
IPR013767
PAS fold
Domain
B [auth D]
IPR000014
PAS domain
Domain
B [auth D]
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
Domain
B [auth D]
IPR014920
Nuclear receptor coactivator, Ncoa-type, interlocking
Domain
B [auth D]
IPR035965
PAS domain superfamily
Homologous Superfamily
B [auth D]
IPR028822
Nuclear receptor coactivator 2, basic helix-loop-helix
Domain
B [auth D]
IPR032565
Nuclear receptor coactivator 2/3, DUF4927
Domain
B [auth D]
IPR036638
Helix-loop-helix DNA-binding domain superfamily
Homologous Superfamily
Pharos: Disease Associations
Pharos Homepage Annotation
Chains
Drug Target  
Associated Disease
B [auth D]
Pharos
: 
Q15596
breast carcinoma
prostate cancer
psoriasis
ulcerative colitis
adenoma
endometriosis
interstitial cystitis
Mammary Neoplasms
osteosarcoma
testicular cancer
atypical teratoid rhabdoid tumor
Crohn disease
Gaucher disease
large cell medulloblastoma
pancreatic intraductal papillary-mucinous neoplasm
breast carcinoma
prostate cancer
psoriasis
ulcerative colitis
adenoma
endometriosis
interstitial cystitis
Mammary Neoplasms
osteosarcoma
testicular cancer
atypical teratoid rhabdoid tumor
Crohn disease
Gaucher disease
large cell medulloblastoma
pancreatic intraductal papillary-mucinous neoplasm
testicular germ cell tumor
breast cancer
endogenous depression
glioblastoma
medulloblastoma
plasma cell myeloma
Less
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