Annotations: 8IVF

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth B]	SCOP2B Superfamily	Lipocalins	8033025	3001332	SCOP2B (2022-06-29)
B [auth A]	SCOP2B Superfamily	Lipocalins	8033025	3001332	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A]	PF00061	Lipocalin / cytosolic fatty-acid binding protein family (Lipocalin)	Lipocalin / cytosolic fatty-acid binding protein family	Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid ...	Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A]	Fatty acid-binding protein, brain	fatty acid binding organic acid binding binding ion binding anion binding lipid binding carboxylic acid binding monocarboxylic acid binding small molecule binding	organic anion transport carboxylic acid transport transport lipid localization lipid transport establishment of localization organic acid transport localization monocarboxylic acid transport fatty acid transport macromolecule localization cell population proliferation cellular process epithelial cell proliferation organic anion transport carboxylic acid transport transport lipid localization lipid transport establishment of localization organic acid transport localization monocarboxylic acid transport fatty acid transport macromolecule localization cell population proliferation cellular process epithelial cell proliferation negative regulation of cell population proliferation regulation of biological process regulation of cellular process regulation of cell population proliferation negative regulation of cellular process biological regulation negative regulation of biological process developmental process multicellular organism development multicellular organismal process anatomical structure development nervous system development system development	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A]	IPR012674	Calycin	Homologous Superfamily
A [auth B], B [auth A]	IPR000463	Cytosolic fatty-acid binding	Domain
A [auth B], B [auth A]	IPR031259	Intracellular lipid binding protein	Family
A [auth B], B [auth A]	IPR000566	Lipocalin/cytosolic fatty-acid binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B], B [auth A]	Pharos: O15540	breast carcinoma breast cancer Liver Cirrhosis, Experimental schizophrenia Alzheimer disease atypical teratoid rhabdoid tumor glioblastoma malignant glioma pituitary cancer Sjogren syndrome astrocytic tumor bipolar disorder cervical cancer large cell medulloblastoma medulloblastoma breast carcinoma breast cancer Liver Cirrhosis, Experimental schizophrenia Alzheimer disease atypical teratoid rhabdoid tumor glioblastoma malignant glioma pituitary cancer Sjogren syndrome astrocytic tumor bipolar disorder cervical cancer large cell medulloblastoma medulloblastoma psoriasis atopic eczema cutaneous lupus erythematosus pilocytic astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.