Annotations: 8OGI

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF03098	Animal haem peroxidase (An_peroxidase)	Animal haem peroxidase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Eosinophil peroxidase light chain	peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor catalytic activity binding organic cyclic compound binding tetrapyrrole binding heme binding lactoperoxidase activity cation binding ion binding metal ion binding small molecule binding	catabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process metabolic process cellular process hydrogen peroxide catabolic process leukocyte migration eosinophil migration immune system process myeloid leukocyte migration cell migration cell motility granulocyte migration multicellular organismal process catabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process metabolic process cellular process hydrogen peroxide catabolic process leukocyte migration eosinophil migration immune system process myeloid leukocyte migration cell migration cell motility granulocyte migration multicellular organismal process regulation of immune effector process regulation of cellular process response to stimulus negative regulation of biological process negative regulation of macrophage cytokine production cytokine production regulation of cytokine production negative regulation of cellular process regulation of immune system process regulation of multicellular organismal process myeloid leukocyte cytokine production cytokine production involved in immune response negative regulation of macromolecule metabolic process production of molecular mediator of immune response regulation of biosynthetic process negative regulation of cytokine production involved in immune response regulation of biological process regulation of cytokine production involved in immune response immune response negative regulation of metabolic process biological regulation negative regulation of immune effector process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process immune effector process regulation of gene expression negative regulation of production of molecular mediator of immune response negative regulation of gene expression biosynthetic process regulation of macrophage cytokine production negative regulation of immune system process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of production of molecular mediator of immune response negative regulation of multicellular organismal process regulation of metabolic process macrophage cytokine production negative regulation of interleukin-5 production regulation of interleukin-5 production interleukin-5 production biological process involved in interspecies interaction between organisms response to other organism defense response defense response to nematode defense response to other organism response to stress response to external stimulus response to external biotic stimulus response to biotic stimulus response to oxidative stress regulation of interleukin-4 production positive regulation of biological process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process positive regulation of interleukin-4 production interleukin-4 production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production defense response to bacterium response to bacterium negative regulation of interleukin-10 production interleukin-10 production regulation of interleukin-10 production	cellular anatomical structure extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cellular anatomical structure extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm
B	Eosinophil peroxidase heavy chain	peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor catalytic activity binding organic cyclic compound binding tetrapyrrole binding heme binding lactoperoxidase activity cation binding ion binding metal ion binding small molecule binding	catabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process metabolic process cellular process hydrogen peroxide catabolic process leukocyte migration eosinophil migration immune system process myeloid leukocyte migration cell migration cell motility granulocyte migration multicellular organismal process catabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process metabolic process cellular process hydrogen peroxide catabolic process leukocyte migration eosinophil migration immune system process myeloid leukocyte migration cell migration cell motility granulocyte migration multicellular organismal process regulation of immune effector process regulation of cellular process response to stimulus negative regulation of biological process negative regulation of macrophage cytokine production cytokine production regulation of cytokine production negative regulation of cellular process regulation of immune system process regulation of multicellular organismal process myeloid leukocyte cytokine production cytokine production involved in immune response negative regulation of macromolecule metabolic process production of molecular mediator of immune response regulation of biosynthetic process negative regulation of cytokine production involved in immune response regulation of biological process regulation of cytokine production involved in immune response immune response negative regulation of metabolic process biological regulation negative regulation of immune effector process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process immune effector process regulation of gene expression negative regulation of production of molecular mediator of immune response negative regulation of gene expression biosynthetic process regulation of macrophage cytokine production negative regulation of immune system process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of production of molecular mediator of immune response negative regulation of multicellular organismal process regulation of metabolic process macrophage cytokine production negative regulation of interleukin-5 production regulation of interleukin-5 production interleukin-5 production biological process involved in interspecies interaction between organisms response to other organism defense response defense response to nematode defense response to other organism response to stress response to external stimulus response to external biotic stimulus response to biotic stimulus response to oxidative stress regulation of interleukin-4 production positive regulation of biological process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process positive regulation of interleukin-4 production interleukin-4 production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production defense response to bacterium response to bacterium negative regulation of interleukin-10 production interleukin-10 production regulation of interleukin-10 production	cellular anatomical structure extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cellular anatomical structure extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR019791	Haem peroxidase, animal-type	Family
A	IPR037120	Haem peroxidase domain superfamily, animal type	Homologous Superfamily
A	IPR050702	Peroxidase/ROS_Generation	Unknown
A	IPR010255	Haem peroxidase superfamily	Homologous Superfamily
B	IPR019791	Haem peroxidase, animal-type	Family
B	IPR037120	Haem peroxidase domain superfamily, animal type	Homologous Superfamily
B	IPR050702	Peroxidase/ROS_Generation	Unknown
B	IPR010255	Haem peroxidase superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P11678	eosinophil peroxidase deficiency asthma osteosarcoma hypereosinophilic syndrome
B	Pharos: P11678	eosinophil peroxidase deficiency asthma osteosarcoma hypereosinophilic syndrome

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.