Annotations: 8OXW

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	CsgC/transglutaminase domain-like	8055227	3002048	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Cysteine proteinases	8041161	3001808	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	E set domains	8055035	3000070	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	CsgC/transglutaminase domain-like	8055478	3002048	SCOP2B (2022-06-29)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B	Heavy Chain	IGHV3	-	protein-glutamine gamma-glutamyltransferase e 27 kda non-catalytic chain	SAbDab (2024-11-15)
C	Light Chain	IGLV6	Lambda	protein-glutamine gamma-glutamyltransferase e 27 kda non-catalytic chain	SAbDab (2024-11-15)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00868	Transglutaminase family (Transglut_N)	Transglutaminase family	-	Domain
A	PF00927	Transglutaminase family, C-terminal ig like domain (Transglut_C)	Transglutaminase family, C-terminal ig like domain	-	Domain
A	PF01841	Transglutaminase-like superfamily (Transglut_core)	Transglutaminase-like superfamily	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding aminoacyltransferase activity protein-glutamine gamma-glutamyltransferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity structural molecule activity	developmental process epithelium development epidermal cell differentiation cellular developmental process epidermis development animal organ development tissue development epithelial cell differentiation skin development cell differentiation keratinocyte differentiation anatomical structure development cellular process macromolecule modification developmental process epithelium development epidermal cell differentiation cellular developmental process epidermis development animal organ development tissue development epithelial cell differentiation skin development cell differentiation keratinocyte differentiation anatomical structure development cellular process macromolecule modification metabolic process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process multicellular organismal process molting cycle process hair cycle epidermis morphogenesis morphogenesis of an epithelium tissue morphogenesis anatomical structure morphogenesis skin epidermis development hair follicle development molting cycle hair cycle process hair follicle morphogenesis keratinization peptide cross-linking	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm protein-containing complex cell periphery extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm protein-containing complex cell periphery extrinsic component of plasma membrane cytoplasmic side of plasma membrane cytoplasmic side of membrane membrane plasma membrane extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane side of membrane
B	Antibody fab fragment heavy chain	-	-	-
C	Antibody fab fragment light chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036985	Transglutaminase-like superfamily	Homologous Superfamily
A	IPR036238	Transglutaminase, C-terminal domain superfamily	Homologous Superfamily
A	IPR002931	Transglutaminase-like	Domain
A	IPR014756	Immunoglobulin E-set	Homologous Superfamily
A	IPR038765	Papain-like cysteine peptidase superfamily	Homologous Superfamily
A	IPR001102	Transglutaminase, N-terminal	Domain
A	IPR008958	Transglutaminase, C-terminal	Domain
A	IPR050779	Protein-glutamine gamma-glutamyltransferases	Family
A	IPR023608	Protein-glutamine gamma-glutamyltransferase, animal	Family
A	IPR013808	Transglutaminase, active site	Active Site
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q08188	skin basal cell carcinoma uncombable hair syndrome esophageal adenocarcinoma uncombable hair syndrome 2 hepatocellular carcinoma psoriasis uncombable hair syndrome 1

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.