8WUB

The X-ray structure of human neuroglobin C120S mutant

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Globin-like	8037518	3000554	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Globin-like	8037518	3000554	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Globin-like	8037518	3000554	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00042	Globin (Globin)	Globin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Neuroglobin	oxygen binding binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on other nitrogenous compounds as donors nitrite reductase activity catalytic activity oxygen carrier activity molecular carrier activity organic cyclic compound binding tetrapyrrole binding heme binding GTPase regulator activity enzyme regulator activity oxygen binding binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on other nitrogenous compounds as donors nitrite reductase activity catalytic activity oxygen carrier activity molecular carrier activity organic cyclic compound binding tetrapyrrole binding heme binding GTPase regulator activity enzyme regulator activity GDP-dissociation inhibitor activity nucleoside-triphosphatase regulator activity molecular function regulator activity cation binding ion binding metal ion binding	oxygen transport localization transport gas transport establishment of localization response to decreased oxygen levels response to stimulus response to hypoxia response to stress response to oxygen levels response to abiotic stimulus cellular response to stimulus cellular response to oxygen levels cellular response to hypoxia oxygen transport localization transport gas transport establishment of localization response to decreased oxygen levels response to stimulus response to hypoxia response to stress response to oxygen levels response to abiotic stimulus cellular response to stimulus cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus cellular response to stress response to chemical cellular process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle mitochondrion membrane-enclosed lumen intracellular membrane-bounded organelle mitochondrial matrix intracellular organelle lumen intracellular organelle organelle lumen organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR009050	Globin-like superfamily	Homologous Superfamily
A, B, C	IPR012292	Globin/Protoglobin	Homologous Superfamily
A, B, C	IPR000971	Globin	Domain
A, B, C	IPR050532	Globin-like Oxygen Transporters	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: Q9NPG2	astrocytic tumor Heredodegenerative Disorders, Nervous System malignant ependymoma oligodendroglioma primitive neuroectodermal tumor atypical teratoid rhabdoid tumor inherited neurodegenerative disorder malignant glioma pilocytic astrocytoma glioblastoma large cell medulloblastoma medulloblastoma pituitary cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.