8BEM

STE20-like serine/threonine-protein kinase (SLK) in complex with Tivozanib

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Protein kinase-like (PK-like)	8034645	3000066	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Protein kinase-like (PK-like)	8034645	3000066	SCOP2B (2022-06-29)
C [auth D]	SCOP2B Superfamily	Protein kinase-like (PK-like)	8034645	3000066	SCOP2B (2022-06-29)
D [auth G]	SCOP2B Superfamily	Protein kinase-like (PK-like)	8034645	3000066	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Pkinase_Tyr	e8bemA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
B	Pkinase_Tyr	e8bemB1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
C [auth D]	Pkinase_Tyr	e8bemD1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
D [auth G]	Pkinase_Tyr	e8bemG1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C [auth D], D [auth G]	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C [auth D], D [auth G]	STE20-like serine/threonine-protein kinase	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding identical protein binding protein binding protein homodimerization activity protein dimerization activity cell adhesion molecule binding cadherin binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein serine kinase activity	regulation of cellular process regulation of cellular component organization cell-substrate junction assembly cellular component organization cellular component biogenesis cell adhesion cellular component assembly cell junction assembly regulation of cell-substrate junction organization cellular component organization or biogenesis focal adhesion assembly regulation of biological process regulation of cell-substrate adhesion regulation of cell adhesion regulation of cellular process regulation of cellular component organization cell-substrate junction assembly cellular component organization cellular component biogenesis cell adhesion cellular component assembly cell junction assembly regulation of cell-substrate junction organization cellular component organization or biogenesis focal adhesion assembly regulation of biological process regulation of cell-substrate adhesion regulation of cell adhesion biological regulation cell-substrate adhesion regulation of cellular component biogenesis regulation of cell junction assembly cell junction organization cell-matrix adhesion regulation of cell-matrix adhesion cell-substrate junction organization cellular process regulation of focal adhesion assembly regulation of cell-substrate junction assembly organelle organization microtubule cytoskeleton organization microtubule-based process cytoplasmic microtubule organization supramolecular fiber organization cytoskeleton organization apoptotic process cell death programmed cell death regulation of apoptotic process regulation of programmed cell death regulation of cell motility regulation of locomotion regulation of cell migration cell migration cell motility locomotion protein phosphorylation organonitrogen compound metabolic process protein autophosphorylation phosphorylation cellular metabolic process primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm cell leading edge

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C [auth D], D [auth G]	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B, C [auth D], D [auth G]	IPR022165	Polo kinase kinase	Family
A, B, C [auth D], D [auth G]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B, C [auth D], D [auth G]	IPR000719	Protein kinase domain	Domain
A, B, C [auth D], D [auth G]	IPR001943	UVR domain	Domain
A, B, C [auth D], D [auth G]	IPR051585	STE20 Subfamily Serine/Threonine Kinases	Family
A, B, C [auth D], D [auth G]	IPR008271	Serine/threonine-protein kinase, active site	Active Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C [auth D], D [auth G]	Pharos: Q9H2G2	lung adenocarcinoma non-small cell lung carcinoma lung cancer malignant mesothelioma neuroblastoma Organic Mental Disorders, Substance-Induced amyotrophic lateral sclerosis ovarian serous adenocarcinoma brain glioma cutaneous melanoma psoriasis drug dependence spina bifida glioblastoma substance dependence lung adenocarcinoma non-small cell lung carcinoma lung cancer malignant mesothelioma neuroblastoma Organic Mental Disorders, Substance-Induced amyotrophic lateral sclerosis ovarian serous adenocarcinoma brain glioma cutaneous melanoma psoriasis drug dependence spina bifida glioblastoma substance dependence hypertensive disorder large cell medulloblastoma malignant ependymoma melanoma ovarian cancer astrocytic tumor pancreatic adenocarcinoma primitive neuroectodermal tumor dermatomyositis renal cell carcinoma substance abuse heart disease interstitial lung disease thyroid gland carcinoma malignant glioma myopathy oligodendroglioma ovarian carcinoma pancreatic intraductal papillary-mucinous neoplasm chronic obstructive pulmonary disease progressive supranuclear palsy skin basal cell carcinoma hydrolethalus syndrome substance-related disorder invasive ductal breast carcinoma uterine corpus leiomyoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.