8GT1

Crystal structure of human cardiac alpha actin A108G mutant (ADP-Pi state) in complex with fragmin F1 domain

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e8gt1A1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF00626	Gelsolin repeat (Gelsolin)	Gelsolin repeat	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Actin, alpha cardiac muscle 1	hydrolase activity catalytic activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding hydrolase activity catalytic activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding protein binding myosin binding cytoskeletal motor activity microfilament motor activity ATP-dependent activity	developmental process mesenchyme migration multicellular organismal process mesenchyme morphogenesis animal organ development mesenchyme development tissue development tissue morphogenesis anatomical structure morphogenesis tissue migration anatomical structure development animal organ morphogenesis heart development cardiac muscle tissue development developmental process mesenchyme migration multicellular organismal process mesenchyme morphogenesis animal organ development mesenchyme development tissue development tissue morphogenesis anatomical structure morphogenesis tissue migration anatomical structure development animal organ morphogenesis heart development cardiac muscle tissue development heart morphogenesis muscle tissue morphogenesis striated muscle tissue development circulatory system development muscle structure development multicellular organism development cardiac muscle tissue morphogenesis muscle organ development muscle tissue development muscle organ morphogenesis system development regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process apoptotic process programmed cell death regulation of biosynthetic process positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular process cellular developmental process cellular component assembly involved in morphogenesis skeletal myofibril assembly cell development membraneless organelle assembly muscle cell differentiation cellular component organization cellular component biogenesis striated muscle cell development cellular anatomical entity morphogenesis cellular component assembly muscle cell development cell differentiation actin filament-based process cellular component organization or biogenesis skeletal muscle thin filament assembly actin cytoskeleton organization actomyosin structure organization organelle assembly actin filament organization organelle organization myofibril assembly anatomical structure formation involved in morphogenesis striated muscle cell differentiation supramolecular fiber organization cytoskeleton organization actin-mediated cell contraction actin filament-based movement actin-myosin filament sliding heart process system process circulatory system process heart contraction blood circulation cardiac muscle cell development cardiac cell development cardiac muscle cell differentiation cardiocyte differentiation cardiac myofibril assembly	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction cell projection cell leading edge plasma membrane bounded cell projection lamellipodium membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction cell projection cell leading edge plasma membrane bounded cell projection lamellipodium membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol synapse glutamatergic synapse blood microparticle intracellular membraneless organelle sarcomere intracellular organelle membraneless organelle contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex polymeric cytoskeletal fiber actin filament actin cytoskeleton cytoskeleton cell body I band actin-based cell projection filopodium
B	Actin-binding protein fragmin P	binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding cation binding metal ion binding	actin filament severing actin filament-based process cellular process regulation of cellular process regulation of cellular component size negative regulation of biological process protein-containing complex disassembly regulation of protein-containing complex disassembly actin filament depolymerization regulation of actin filament depolymerization cellular component biogenesis actin filament capping cellular component assembly negative regulation of supramolecular fiber organization actin filament severing actin filament-based process cellular process regulation of cellular process regulation of cellular component size negative regulation of biological process protein-containing complex disassembly regulation of protein-containing complex disassembly actin filament depolymerization regulation of actin filament depolymerization cellular component biogenesis actin filament capping cellular component assembly negative regulation of supramolecular fiber organization regulation of biological quality negative regulation of actin filament polymerization cellular component disassembly regulation of biological process barbed-end actin filament capping negative regulation of cellular component organization actin filament organization regulation of organelle organization negative regulation of protein depolymerization negative regulation of protein-containing complex assembly regulation of protein polymerization regulation of supramolecular fiber organization supramolecular fiber organization regulation of cytoskeleton organization regulation of cellular component organization regulation of actin filament-based process cellular component organization regulation of protein-containing complex assembly negative regulation of protein-containing complex disassembly negative regulation of cellular process protein-containing complex assembly negative regulation of protein polymerization cellular component organization or biogenesis regulation of actin filament polymerization actin polymerization or depolymerization protein polymerization regulation of actin filament organization actin cytoskeleton organization actin filament polymerization protein-containing complex organization regulation of protein depolymerization negative regulation of cytoskeleton organization biological regulation regulation of actin polymerization or depolymerization regulation of cellular component biogenesis organelle organization negative regulation of organelle organization regulation of actin filament length regulation of actin cytoskeleton organization negative regulation of actin filament depolymerization protein depolymerization cytoskeleton organization regulation of anatomical structure size	cellular anatomical structure intracellular anatomical structure cytoplasm intracellular organelle cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR020902	Actin/actin-like conserved site	Conserved Site
A	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
A	IPR004001	Actin, conserved site	Conserved Site
A	IPR004000	Actin family	Family
B	IPR007123	Gelsolin-like domain	Domain
B	IPR007122	Villin/Gelsolin	Family
B	IPR029006	ADF-H/Gelsolin-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P68032	atrial septal defect 5 hypertrophic cardiomyopathy 11 left ventricular noncompaction dilated cardiomyopathy hypertrophic cardiomyopathy dilated cardiomyopathy 1R cardiomyopathy gastric cancer large cell medulloblastoma limb-girdle muscular dystrophy Ametropia medulloblastoma psoriasis restrictive cardiomyopathy dilated cardiomyopathy 1A atrial septal defect 5 hypertrophic cardiomyopathy 11 left ventricular noncompaction dilated cardiomyopathy hypertrophic cardiomyopathy dilated cardiomyopathy 1R cardiomyopathy gastric cancer large cell medulloblastoma limb-girdle muscular dystrophy Ametropia medulloblastoma psoriasis restrictive cardiomyopathy dilated cardiomyopathy 1A Emery-Dreifuss muscular dystrophy familial hypertrophic cardiomyopathy gastric neoplasm malignant glioma amyotrophic lateral sclerosis myopathy Becker muscular dystrophy precancerous condition refractive error facioscapulohumeral muscular dystrophy familial isolated dilated cardiomyopathy hereditary diffuse gastric adenocarcinoma juvenile dermatomyositis atrial septal defect osteosarcoma Charcot-Marie-Tooth disease Duchenne muscular dystrophy familial dilated cardiomyopathy

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	HIC	Parent Component: HIS RESID: AA0317 PSI-MOD : 1'-methyl-L-histidine MOD:00322

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.