9GPO

The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog 12c/n

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Peptidyl-prolyl cis-trans isomerase FKBP5	isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity FK506 binding amide binding binding organic cyclic compound binding macrolide binding protein binding heat shock protein binding protein-macromolecule adaptor activity molecular adaptor activity	protein folding biosynthetic process metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process protein maturation biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to bacterium protein folding biosynthetic process metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process protein maturation biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus chaperone-mediated protein folding response to chemical response to oxygen-containing compound response to nitrogen compound response to organic cyclic compound response to cocaine response to alkaloid response to alcohol	cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR046357	Peptidyl-prolyl cis-trans isomerase domain superfamily	Homologous Superfamily
A, B	IPR050754	Peptidyl-prolyl cis-trans isomerase FKBP4/5/8-like	Family
A, B	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A, B	IPR001179	FKBP-type peptidyl-prolyl cis-trans isomerase domain	Domain
A, B	IPR019734	Tetratricopeptide repeat	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q13451	rheumatoid arthritis endometriosis major depressive disorder Neurobehavioral Manifestations glioblastoma ovarian cancer hepatocellular carcinoma pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma astrocytic tumor lung lymphangioleiomyomatosis bipolar disorder Sjogren syndrome tuberous sclerosis colorectal cancer rheumatoid arthritis endometriosis major depressive disorder Neurobehavioral Manifestations glioblastoma ovarian cancer hepatocellular carcinoma pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma astrocytic tumor lung lymphangioleiomyomatosis bipolar disorder Sjogren syndrome tuberous sclerosis colorectal cancer malignant glioma disappearing bone disease myopathy gastric cancer Hashimoto thyroiditis pancreatic ductal adenocarcinoma hydrolethalus syndrome pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia interstitial cystitis anxiety disorder lung adenocarcinoma atopic eczema cystic fibrosis malignant pancreatic neoplasm Duchenne muscular dystrophy mood disorder gastric carcinoma opiate dependence heart disease pancreatic intraductal papillary-mucinous carcinoma hypothyroidism Pick disease large cell medulloblastoma psoriasis asthma lung cancer renal cell carcinoma atypical teratoid rhabdoid tumor lymphangioma sinusitis tuberculosis colorectal adenoma malignant ependymoma depressive disorder medulloblastoma Emery-Dreifuss muscular dystrophy exocrine pancreatic carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.