Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad9papa_ Alpha and beta proteins (a+b) Cysteine proteinases Cysteine proteinases Papain-like Papain papaya (Carica papaya ) [TaxId: 3649 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyCysteine proteinases 8036216 3001808 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APeptidase_C1e9papA1 A: a+b complex topologyX: Cysteine proteinases-likeH: Cysteine proteinases (From Topology)T: Cysteine proteinasesF: Peptidase_C1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B Chain ACATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00112Papain family cysteine protease (Peptidase_C1)Papain family cysteine protease- Domain

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
OCS Parent Component: CYS

RESIDAA0556

PSI-MOD :  L-cysteic acid (L-cysteine sulfonic acid) MOD:00460

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
papain  M-CSA #174

Papin is a member of the thiol protease family, which is a large, well-studied group with a well-known \"catalytic triad\" motif in which a cysteine acts as the catalytic nucleophile, activated by His and Asn. Papin catalyses the hydrolysis of proteins with broad specificity for peptide bonds, but shows a marked preference for an amino acid bearing a large hydrophobic side chain at the P2 position and does not accept Val in P1'.

Defined by 4 residues: GLN:A-19CYS:A-25HIS:A-159ASN:A-175
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