Sesterfisherol synthase

UniProtKB accession:  A1DN30

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Bifunctional terpene synthase; part of the gene cluster that mediates the biosynthesis of sesterfisheric acid (PubMed:26332841). The bifunctional terpene synthase NfSS converts dimethylallyl diphosphate (DMAPP) and isopentenyl diphosphate (IPP) into sesterfisherol (PubMed:26332841, PubMed:29410538). The C-terminal prenyltransferase (PT) domain of NfSS catalyzes formation of geranylfarnesyl pyrophosphate (GFPP), whereas the N-terminal terpene cyclase (TC) domain catalyzes the cyclization of GFPP to sesterfisherol (PubMed:26332841, PubMed:29410538). The cytochrome P450 monooxygenase NfP450 then catalyzes oxidative modifications of sesterfisherol into sesterfisheric acid (PubMed:26332841).