Heme oxygenase 1

UniProtKB accession:  P06762

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (PubMed:1575508, PubMed:1935972, PubMed:3865203). Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (By similarity).