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2-hydroxyacyl-CoA lyase

UniProtKB accession:  P0DUV9
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Go to UniProtKB:  P0DUV9
UniProtKB description:  A lyase that reversibly degrades 2-hydroxyisobutyryl-CoA (2-HIB-CoA) to acetone and formyl-CoA (PubMed:34952003). Probably also cleaves 2-hydroxy-2-methylbutyryl-CoA to butanone and formyl-CoA. Does not act on 2-hydroxy-2-ethylbutyryl-CoA (Probable). A C-terminal lid closes the active site upon substrate binding, and with residues Leu-127 and Ile-492 restricts the size of the active site cavity so it can only use short-chain (C4 and C5) acyl substrates (PubMed:34952003). Part of a pathway that allows cells to grow on 2-methylpropane-1,2-diol or 2-hydroxyisobutyric acid (2-HIBA) as a sole carbon source (PubMed:32351493).
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