Thoeris anti-defense 1

UniProtKB accession:  P0DW61

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Blocks activity of the Thoeris antiviral defense system (ThsA and ThsB) (PubMed:36174646). Binds and sequesters the cyclic ADP-D-ribose signal molecule (cADPR) generated by ThsB (AC J8G8J6), ThsB' (AC J8CSK2, probably 3'cADPR), BdTIR (AC I1GTC2, 2'cADPR) and AaTIR (AC A0A1H7VGH3, 3'cADPR). Sequestration prevents the signal from activating the Thoeris antiviral defense system; heating cmTad1 bound to the signal (95 degrees Celsius for 15 minutes) restores the ability of the signal to activate the NAD(+) hydrolase activity of ThsA (AC J8G6Z1) (PubMed:36174646).