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Enterobactin synthase component F

UniProtKB accession:  P11454
Grouped By:  Matching UniProtKB accession
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Go to UniProtKB:  P11454
UniProtKB description:  Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine (PubMed:1338974, PubMed:1826089, PubMed:216414, PubMed:9485415). EntF catalyzes the activation of L-serine via ATP-dependent PPi exchange reaction to form seryladenylate (PubMed:10688898, PubMed:1338974, PubMed:1826089, PubMed:9485415). Activated L-serine is loaded onto the peptidyl carrier domain via a thioester linkage to the phosphopanthetheine moiety, forming seryl-S-Ppant-EntF (PubMed:9485415). EntF acts then as the sole catalyst for the formation of the three amide and three ester linkages found in enterobactin, using seryladenylate and 2,3-dihydroxybenzoate-S-Ppant-EntB (DHB-S-Ppant-EntB) as substrates, via the formation of a DHB-Ser-S-Ppant-EntF intermediate (PubMed:9485415).
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