Na(+)/H(+) antiporter NhaA

UniProtKB accession:  P13738

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UniProtKB description:  Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons (PubMed:1645730, PubMed:23836890, PubMed:2839489, PubMed:7737413, PubMed:8019504, PubMed:8383669). Plays an important role in the regulation of intracellular pH, cellular Na(+) content and cell volume (PubMed:33129932). Catalyzes the exchange of 2 H(+) per Na(+) (PubMed:23836890, PubMed:8383669). This stoichiometry applies at both neutral and alkaline pH values (PubMed:8383669). In addition, can also transport lithium and is involved in lithium detoxification (PubMed:22915592, PubMed:27021484, PubMed:7737413, PubMed:8019504). Binding of the Li(+) and H(+) ligands to NhaA is coupled and antagonistic (PubMed:27021484).