Help  

Retinoic acid receptor beta

UniProtKB accession:  P22605
Grouped By:  Matching UniProtKB accession
Group Content:  
Go to UniProtKB:  P22605
UniProtKB description:  Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (By similarity). The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (PubMed:19389355).
Group Members:
Release Date:


Structure Features


Sequence Features


Experimental Features


Organisms


Protein Domains


Function