Steroid C26-monooxygenase

UniProtKB accession:  P9WPP1

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection (PubMed:20545858, PubMed:20843794). Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26-hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25S)-3-oxocholest-4-en-26-oate (PubMed:19846551, PubMed:20545858, PubMed:20843794). Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one (PubMed:19846551, PubMed:20545858, PubMed:20843794).