Protein smoothened

UniProtKB accession:  Q5RH73

Grouped By:  Matching UniProtKB accession

UniProtKB description:  G protein-coupled receptor which associates with the patched protein (ptch) to transduce Hedgehog protein signaling. Binding of sonic hedgehog (shh) to its receptor patched prevents inhibition of smoothened (smo) by patched. When active, smo binds to and sequesters protein kinase A catalytic subunit prkaca at the cell membrane, preventing prkaca-mediated phosphorylation of gli transcription factors which releases the gli proteins from prkaca-mediated inhibition and allows for transcriptional activation of Hedgehog signaling pathway target genes (By similarity). Required for the development of primary and secondary motoneurons but not for the specification of midbrain dopaminergic neurons or development of the medial floor plate (PubMed:11493557). Required for induction of lateral floor plate and posterior motoneurons, anterior neural plate patterning, dorsoventral forebrain patterning, dorsoventral retinal patterning, optic stalk development, and formation of the forebrain primary axonal scaffold (PubMed:11566855). Required to regulate the formation of a subset of cerebellar neurons by limiting wnt1 expression which controls cerebellar expression of transcription factor olig2 (PubMed:18423594). Required for development of the pancreas (PubMed:34087472). Required for muscle development (PubMed:16136078). Required for the formation of a single continuous intestinal lumen from multiple discontinuous lumens, probably by regulating remodeling through rab11a-mediated trafficking to facilitate lumen fusion (PubMed:24504339). Required for development of the adenohypophysis (PubMed:11566855, PubMed:12606279). Required for anteroposterior patterning of the otic vesicle (PubMed:12588855). Required for development of the anterior craniofacial skeleton (PubMed:16481351). Required for patterning of the caudal fin (PubMed:17597528). Required during gastrulation and early somitogenesis stages to promote cardiomyocyte formation by regulating the specification of myocardial progenitors (PubMed:18842815). Required for induction of arterial endothelial cell formation by repressing venous cell fate (PubMed:20193674).