RNA-directed RNA polymerase L

UniProtKB accession:  Q6TQR6

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UniProtKB description:  Displays RNA-directed RNA polymerase, deubiquitinating and deISGylase activities (PubMed:18078692, PubMed:21228232, PubMed:21245344, PubMed:23345508). RNA-dependent RNA polymerase is responsible for replication and transcription of the viral RNA genome (PubMed:18078692). During transcription, synthesizes subgenomic RNAs and assures their capping by a cap-snatching mechanism, which involves the endonuclease activity cleaving the host capped pre-mRNAs (By similarity). These short capped RNAs are then used as primers for viral transcription (By similarity). The deubiquitinating and deISGylating activities specifically cleaves poly-ubiquitinated conjugates and ISG15 from RIG-I, interfering with antiviral signaling pathways mediated by NF-kappaB and IRF signalings (PubMed:18078692, PubMed:21266548, PubMed:28877473). Deubiquitinates mono-ubiquitinated, K48- and K63-linked tetra-ubiquitinated molecules (PubMed:21228232). Favors K63 poly-Ub linkage (PubMed:23345508).