Actin-1

UniProtKB accession:  Q8I4X0

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm (PubMed:24743229, PubMed:28923924, PubMed:31199804). Polymerizes into shorter and less stable actin filaments compared to ACT2/actin-2; this is thought to facilitate gliding motility and host cell invasion (PubMed:24743229, PubMed:28923924). Has ATPase activity (PubMed:24743229, PubMed:31199804). ATP hydrolysis leads to the formation of a stable intermediate ADP-inorganic phosphate (Pi) actin, which is followed by the release of Pi (Probable). ATP hydrolysis affects filament stability; ADP-bound actin depolymerizes much faster than ATP- or ADP-Pi-bound actin (Probable). Plays an essential role during the asexual blood stage (PubMed:28810863). At the segmented schizont stage, required for apicoplast migration and segregation into individual daughter merozoites (PubMed:28810863). Also, required for the separation of daughter merozoites in the final stages of cytokinesis (PubMed:28810863). Essential for merozoite invasion of, but not adhesion to or reorientation towards, host erythrocytes (PubMed:28810863).