Jasmonate-induced oxygenase 2

UniProtKB accession:  Q9FFF6

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UniProtKB description:  2-oxoglutarate-dependent dioxygenase involved in the oxidation of jasmonate (JA), a stress-induced phytohormone synthesized in response to attack by pathogens and herbivores, which triggers the activation of defense responses via the JA-mediated signaling pathway (PubMed:28559313, PubMed:28760569). Converts JA to 12-hydroxyjasmonate (12OH-JA), an inactive form of JA (PubMed:28559313, PubMed:28760569, PubMed:33516967). Is specific to free JA, and cannot oxidize the bioactive form jasmonoyl-L-isoleucine (JA-Ile) or other JA-amino acid conjugates (PubMed:28760569, PubMed:33516967). Prevents over-accumulation of JA and indirectly its bioactive form JA-Ile under stress response (PubMed:28559313, PubMed:28760569). Acts as a negative regulator of JA-mediated defense signaling, by contributing to 12OH-JA accumulation, which represses JA defense responses upon infection by the fungal pathogen Botrytis cinerea (PubMed:28559313, PubMed:28760569). Acts as a negative regulator of JA-mediated defense responses upon infestation by the herbivorous caterpillar Mamestra brassicae (PubMed:28559313). May be involved in the catabolism of cytotoxic polycyclic aromatic hydrocarbons (PAHs) (PubMed:27637093).