Bifunctional polynucleotide phosphatase/kinase
UniProtKB accession: Q9JLV6
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Go to UniProtKB: Q9JLV6
UniProtKB description: Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.
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