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Glutamate receptor ionotropic, NMDA 3A

UniProtKB accession:  Q9R1M7
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Go to UniProtKB:  Q9R1M7
UniProtKB description:  NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. During the development of neural circuits, plays a role in the synaptic refinement period, restricting spine maturation and growth. By competing with GIT1 interaction with ARHGEF7/beta-PIX, may reduce GIT1/ARHGEF7-regulated local activation of RAC1, hence affecting signaling and limiting the maturation and growth of inactive synapses (PubMed:24297929, PubMed:25009255). May also play a role in PPP2CB-NMDAR mediated signaling mechanism.
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